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Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction

• Authors : Jae Hyun Kim; Kilsoo Jung; Chulho Lee

Subjects: Cell Line; Cell Survival / drug effects; Dose-Response Relationship

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Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors

• Authors : Areum Park; Jieon Hwang; Joo-Youn Lee

Subjects: Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology

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Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death

• Authors : Russo, Luigi; Mascanzoni, Fabiola; Farina, Biancamaria

Subjects: Animals; Apoptosis/drug effects; Apoptosis Inducing Factor/chemical synthesis

• Source: Russo , L , Mascanzoni , F , Farina , B , Dolga , A M , Monti , A , Caporale , A , Culmsee , C , Fattorusso , R , Ruvo , M & Doti , N 2021 , ' Design, Optimization, and Structural Characterization of

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Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

• Authors : Mohammad-Beigi, Hossein; Aliakbari, Farhang; Sahin, Cagla

Subjects: synuclein (-synuclein); ADHERENCE; AGGREGATION

• Source: Mohammad-Beigi , H , Aliakbari , F , Sahin , C , Lomax , C , Tawfike , A , P. Schafer , N , Amiri-Nowdijeh , A , Eskandari , H , Møller , I M , Hosseini-Mazinani , M , Christiansen , G , Ward , J L ,

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Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells

• Authors : Jiménez, Rafael; Pequerul, Raquel; Amor Minguez, Adrián

Subjects: Aldehyde dehydrogenase; Cancer; Cancer stem cell

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Suppression of T24 human bladder cancer cells by ROS from locally delivered hematoporphyrin-containing polyurethane films

• Authors : College of Medicine; Dept. of Medical Engineering; Dohyun Kim

Subjects: Antineoplastic Agents/chemistry/*pharmacology; Apoptosis/drug effects; Cell Cycle/drug effects

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Cholesterol modification of an anticancer drug for efficient incorporation into a supramolecular hydrogel system

• Authors : Bakker, Maarten H.; Grillaud, Maxime; Wu, Dan Jing

Subjects: Cholesterol; Controlled release; Drug delivery

• Source: Bakker , M H , Grillaud , M , Wu , D J , Fransen , P P K H , de Hingh , I H & Dankers , P Y W 2018 , ' Cholesterol modification of an anticancer drug for efficient

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Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

• Authors : College of Medicine; Dept. of Pathology; Gi-Bang Koo

Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Breast Neoplasms/drug therapy

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Total Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues

• Authors : Minkyu Kim; Yongseo Park; Won-Yoon Chung

Subjects: Antineoplastic Agents; Phytogenic/chemical synthesis; Phytogenic/chemistry

• Source: T201503995.pdf

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Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems

• Authors : Twum, Elvis A; Nathubhai, Amit; Wood, Pauline J

Subjects: Acetamides; Alkylation; Antineoplastic Agents

• Source: Twum , E A , Nathubhai , A , Wood , P J , Lloyd , M D , Thompson , A S & Threadgill , M D 2015 , ' Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems ' ,

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