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  • 1-10 ل  39,275 نتائج ل ""Tyrosine""

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Subject : signal transduction
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Academic Journal

Fenebrutinib, a Bruton's tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways.

  • Authors : Langlois J; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.; Lange S

Subjects: Microglia*/Microglia*/Microglia*/drug effects ; Microglia*/Microglia*/Microglia*/metabolism ; Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Oct 27; Vol. 21 (1), pp. 276. Date of Electronic Publication: 2024 Oct 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Academic Journal

RON receptor tyrosine kinase regulates glycolysis through MAPK/CREB signaling to affect ferroptosis and chemotherapy sensitivity of thyroid cancer cells.

  • Authors : Jin X; School of Medicine, Shaoxing University, Shaoxing, Zhejiang 312000, P.R. China.; Zhu H

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/metabolism ; Glycolysis*/Glycolysis*/Glycolysis*/drug effects

  • Source: Molecular medicine reports [Mol Med Rep] 2024 Dec; Vol. 30 (6). Date of Electronic Publication: 2024 Oct 18.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Recent Developments in the Role of Protein Tyrosine Phosphatase 1B (PTP1B) as a Regulator of Immune Cell Signalling in Health and Disease.

  • Authors : Read NE; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.; Wilson HM

Subjects: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/Protein Tyrosine Phosphatase, Non-Receptor Type 1*/Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1*/Protein Tyrosine Phosphatase, Non-Receptor Type 1*/Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics ; Signal Transduction*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 29; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Human Cytomegalovirus Dysregulates Cellular Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases and Sonic Hedgehog Pathway Proteins in Neural Astrocyte and Placental Models.

  • Authors : Egilmezer E; Serology and Virology Division, Microbiology, NSW Health Pathology, Prince of Wales Hospital, Sydney 2031, Australia.; School of Clinical Medicine, University of New South Wales, Kensington 2052, Australia.

Subjects: Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/genetics ; Cytomegalovirus*/Cytomegalovirus*/Cytomegalovirus*/physiology

  • Source: Viruses [Viruses] 2024 Jun 05; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

SPROUTY2, a Negative Feedback Regulator of Receptor Tyrosine Kinase Signaling, Associated with Neurodevelopmental Disorders: Current Knowledge and Future Perspectives.

  • Authors : Puranik N; Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea.; Jung H

Subjects: Neurodevelopmental Disorders*/Neurodevelopmental Disorders*/Neurodevelopmental Disorders*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 14; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Mechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs.

  • Authors : Wei Q; Bethune International Peace Hospital of PLA Hepatobiliary Surgery, Shijiazhuang, 050082, China.; Luo S

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Apr 21; Vol. 14 (1), pp. 9128. Date of Electronic Publication: 2024 Apr 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Klotho enhances stability of chronic kidney disease atherosclerotic plaques by inhibiting GRK2/PLC-β-mediated endoplasmic reticulum stress in macrophages via modulation of the ROS/SHP1 pathway.

  • Authors : Li Z; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China.

Subjects: Klotho Proteins* ; Glucuronidase*/Glucuronidase*/Glucuronidase*/metabolism ; Glucuronidase*/Glucuronidase*/Glucuronidase*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Dec 30; Vol. 14 (1), pp. 32091. Date of Electronic Publication: 2024 Dec 30.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction.

  • Authors : Zong Y; Clinical Laboratory, Hebei General Hospital, Shijiazhuang, Hebei, China. .; Hebei Key Laboratory of Molecular Medicine, Shijiazhuang, Hebei, China. .

Subjects: Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/metabolism ; Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/pathology ; Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/genetics

  • Source: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 30938. Date of Electronic Publication: 2024 Dec 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation.

  • Authors : Jin C; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, P. R. China.; Institute of Urology, Anhui Medical University, Hefei, Anhui, 230022, P. R. China.

Subjects: Chemokine CCL5*/Chemokine CCL5*/Chemokine CCL5*/metabolism ; Chemokine CCL5*/Chemokine CCL5*/Chemokine CCL5*/genetics ; Signal Transduction*

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Dec 05; Vol. 22 (1), pp. 584. Date of Electronic Publication: 2024 Dec 05.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Academic Journal

Hypoxia-activated oxidative stress mediates SHP2/PI3K signaling pathway to promote hepatocellular carcinoma growth and metastasis.

  • Authors : Niu Z; Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, China.; Zhao Q

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Feb 10; Vol. 15 (1), pp. 4847. Date of Electronic Publication: 2025 Feb 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 ل  39,275 نتائج ل ""Tyrosine""