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Academic Journal

Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway.

  • Authors : Zhou J; School of Medicine, Anhui University of Science and Technology, Huainan, Anhui, 232000, China.; School of Medicine, The First Affiliated Hospital of Anhui University of Science and Technology Huainan First People's Hospital, Huainan, Anhui, 232000, China.

Subjects: Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/pathology ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/genetics ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/metabolism

  • Source: Journal of translational medicine [J Transl Med] 2025 Apr 11; Vol. 23 (1), pp. 434. Date of Electronic Publication: 2025 Apr 11.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

Knockout or inhibition of DHPS suppresses ovarian tumor growth and metastasis by attenuating the TGFβ pathway.

  • Authors : Zhao G; Department of Pathology and Laboratory Medicine, Collage of Medicine, the University of Tennessee Health Science Center, Memphis, TN, 38163, United States.; Center for Cancer Research, Collage of Medicine, the University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Subjects: Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/pathology ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/genetics ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Jan 06; Vol. 15 (1), pp. 917. Date of Electronic Publication: 2025 Jan 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeting TSPEAR-AS2 suppresses tumor growth and interferon signaling in esophageal cancer.

  • Authors : Zhang C; Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China.; Cui Y

Subjects: Esophageal Neoplasms*/Esophageal Neoplasms*/Esophageal Neoplasms*/metabolism ; Esophageal Neoplasms*/Esophageal Neoplasms*/Esophageal Neoplasms*/genetics ; Esophageal Neoplasms*/Esophageal Neoplasms*/Esophageal Neoplasms*/pathology

  • Source: Scientific reports [Sci Rep] 2024 Nov 20; Vol. 14 (1), pp. 28768. Date of Electronic Publication: 2024 Nov 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

IL-32γ Induced Autophagy Through Suppression of MET and mTOR Pathways in Liver Tumor Growth Inhibition.

  • Authors : Seo JW; College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31, Osongsaengmyeong 1-ro, Osong-eup, Cheongju-si 28160, Chungbuk, Republic of Korea.; Lee YS

Subjects: Autophagy* ; TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/metabolism ; Interleukins*/Interleukins*/Interleukins*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 30; Vol. 25 (21). Date of Electronic Publication: 2024 Oct 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling.

  • Authors : Chi LH; Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, VIC, 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.

Subjects: Smad4 Protein*/Smad4 Protein*/Smad4 Protein*/genetics ; Smad4 Protein*/Smad4 Protein*/Smad4 Protein*/metabolism ; Bone Morphogenetic Protein 4*/Bone Morphogenetic Protein 4*/Bone Morphogenetic Protein 4*/genetics

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Apr 30; Vol. 22 (1), pp. 248. Date of Electronic Publication: 2024 Apr 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Academic Journal

Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.

  • Authors : Naranjo AI; Biochemistry and Molecular Biology Branch, Medical School/CRIB/Biomedicine Unit, Department of Inorganic and Organic Chemistry and Biochemistry, University of Castilla-La Mancha (UCLM)/CSIC, 02008 Albacete, Spain.; González-Gómez MJ

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology ; Intercellular Signaling Peptides and Proteins*/Intercellular Signaling Peptides and Proteins*/Intercellular Signaling Peptides and Proteins*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 29; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth.

  • Authors : Li J; Department of Nuclear Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Zhang Z

Subjects: Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/genetics ; Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/metabolism ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics

  • Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2022 Mar; Vol. 477 (3), pp. 649-661. Date of Electronic Publication: 2021 Dec 06.Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer.

  • Authors : Karim S; Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Burzangi AS

Subjects: Benzoquinones/Benzoquinones/Benzoquinones/*pharmacology ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 19; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2.

  • Authors : Mia MS; Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA.; Jarajapu Y

Subjects: Carcinogenesis/Carcinogenesis/Carcinogenesis/*metabolism ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*genetics ; Integrin beta1/Integrin beta1/Integrin beta1/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway.

  • Authors : Gong Q; Department of Palliative Medicine, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P.R. China.; Deng J

Subjects: Signal Transduction*; Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*metabolism ; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*metabolism

  • Source: Molecular medicine reports [Mol Med Rep] 2021 Aug; Vol. 24 (2). Date of Electronic Publication: 2021 Jun 24.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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