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Academic Journal

S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma.

  • Authors : Zhou X; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.; Liu J

Subjects: Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/pathology ; Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/metabolism ; Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/genetics

  • Source: Journal of translational medicine [J Transl Med] 2025 May 23; Vol. 23 (1), pp. 573. Date of Electronic Publication: 2025 May 23.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma.

  • Authors : Qiu L; Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, 100081, China.; Gao Q

Subjects: PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/metabolism ; PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/antagonists & inhibitors ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects

  • Source: Journal of translational medicine [J Transl Med] 2025 Feb 03; Vol. 23 (1), pp. 145. Date of Electronic Publication: 2025 Feb 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.

  • Authors : Zhang R; Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.; Wen Y

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/genetics ; Cell Cycle*/Cell Cycle*/Cell Cycle*/genetics ; Forkhead Transcription Factors*/Forkhead Transcription Factors*/Forkhead Transcription Factors*/metabolism

  • Source: Journal of translational medicine [J Transl Med] 2024 Jul 30; Vol. 22 (1), pp. 710. Date of Electronic Publication: 2024 Jul 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways.

  • Authors : Cidem A; Department of Life Sciences, College of Life Sciences, National Chung Hsing University, Kuo Kuang Rd., Taichung, 402, Taiwan.; Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, 25250, Turkey.

Subjects: Lactoferrin*/Lactoferrin*/Lactoferrin*/pharmacology ; Lactoferrin*/Lactoferrin*/Lactoferrin*/administration & dosage ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/drug therapy

  • Source: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31210. Date of Electronic Publication: 2024 Dec 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells.

  • Authors : Chen J; School of Public Health, Bengbu Medical University, Bengbu, China.; Ji Z

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/genetics

  • Source: Scientific reports [Sci Rep] 2025 Mar 17; Vol. 15 (1), pp. 9148. Date of Electronic Publication: 2025 Mar 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway.

  • Authors : Liang J; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300000, China.; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, 300000, China.

Subjects: Glioma*/Glioma*/Glioma*/pathology ; Glioma*/Glioma*/Glioma*/metabolism ; Glioma*/Glioma*/Glioma*/genetics

  • Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 Jan; Vol. 480 (1), pp. 589-605. Date of Electronic Publication: 2024 Apr 08.Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction.

  • Authors : Huang KC; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Subjects: Retinal Ganglion Cells*/Retinal Ganglion Cells*/Retinal Ganglion Cells*/pathology ; Retinal Ganglion Cells*/Retinal Ganglion Cells*/Retinal Ganglion Cells*/metabolism ; Autophagy*/Autophagy*/Autophagy*/physiology

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Oct 18; Vol. 12 (1), pp. 164. Date of Electronic Publication: 2024 Oct 18.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

PLK1-activating IFI16-STING-TBK1 pathway induces apoptosis of intestinal epithelial cells in patients with intestinal Behçet's syndrome.

  • Authors : Bao HF; Department of Rheumatology and Immunology, Huadong Hospital, Fudan University, Shanghai, China.; She CH

Subjects: Behcet Syndrome*/Behcet Syndrome*/Behcet Syndrome*/pathology ; Behcet Syndrome*/Behcet Syndrome*/Behcet Syndrome*/metabolism ; Behcet Syndrome*/Behcet Syndrome*/Behcet Syndrome*/genetics

  • Source: The FEBS journal [FEBS J] 2024 Aug; Vol. 291 (15), pp. 3432-3453. Date of Electronic Publication: 2024 Apr 27.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

Myeloid SHP2 attenuates myocardial ischemia‑reperfusion injury via regulation of BRD4/SYK/STING/NOX4/NLRP3 signaling.

  • Authors : Liu Y; Department of Cardiovascular Disease and Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.; Yin H

Subjects: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics ; Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/Myocardial Reperfusion Injury*/metabolism

  • Source: Molecular medicine reports [Mol Med Rep] 2025 Jun; Vol. 31 (6). Date of Electronic Publication: 2025 Apr 11.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Rinsenoside Rg1 and its involvement in Hippo-YAP signaling pathway alleviating symptoms of depressive-like behavior.

  • Authors : Gao L; Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, 21 Bohai Road, Tang'shan, 063210, Hebei, China.; Wang J

Subjects: Ginsenosides*/Ginsenosides*/Ginsenosides*/pharmacology ; Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects ; Depression*/Depression*/Depression*/drug therapy

  • Source: Scientific reports [Sci Rep] 2025 Apr 25; Vol. 15 (1), pp. 14441. Date of Electronic Publication: 2025 Apr 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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