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Academic Journal

Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for Age-Related Neuropathogenesis.

  • Authors : Avalos B; Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.; Kulbe JR

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/genetics ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism

  • Source: Viruses [Viruses] 2024 Sep 24; Vol. 16 (10). Date of Electronic Publication: 2024 Sep 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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Academic Journal

Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2.

  • Authors : Park JC; Department of Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep; Vol. 11 (34), pp. e2400064. Date of Electronic Publication: 2024 Jul 09.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer.

  • Authors : Wang Q; Center for Infection and Immunity, Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.; Department of Clinical Laboratory, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

Subjects: Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/metabolism ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/immunology ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/pathology

  • Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Aug 13; Vol. 43 (1), pp. 224. Date of Electronic Publication: 2024 Aug 13.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

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Academic Journal

Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease.

  • Authors : Long H; Alector, Inc., South San Francisco, CA, 94080, USA.; Simmons A

Subjects: Receptors, Immunologic* ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/agonists ; Macaca fascicularis*

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Oct 23; Vol. 16 (1), pp. 235. Date of Electronic Publication: 2024 Oct 23.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Clusterin from endometrial glands plays a critical role in decidualization via Trem2.

  • Authors : Yao S; College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.; Chen Y

Subjects: Clusterin*/Clusterin*/Clusterin*/metabolism ; Clusterin*/Clusterin*/Clusterin*/genetics ; Decidua*/Decidua*/Decidua*/metabolism

  • Source: BMC genomics [BMC Genomics] 2024 Oct 16; Vol. 25 (1), pp. 969. Date of Electronic Publication: 2024 Oct 16.Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164

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Academic Journal

Trem2 acts as a non-classical receptor of interleukin-4 to promote diabetic wound healing.

  • Authors : Zhu X; Department of Dermatology, Shanghai Key Laboratory of Medical Mycology; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/genetics ; Wound Healing*/Wound Healing*/Wound Healing*/genetics

  • Source: Clinical and translational medicine [Clin Transl Med] 2024 Oct; Vol. 14 (10), pp. e70026.Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326

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Academic Journal

A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms.

  • Authors : Liang J; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Menon A

Subjects: Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/genetics ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 06; Vol. 25 (17). Date of Electronic Publication: 2024 Sep 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Age-related changes to macrophage subpopulations and TREM2 dysregulation characterize attenuated fracture healing in old mice.

  • Authors : Clark D; Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA.; Department of Periodontics and Preventive Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA.

Subjects: Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/metabolism ; Receptors, Immunologic*/Receptors, Immunologic*/Receptors, Immunologic*/genetics ; Macrophages*/Macrophages*/Macrophages*/metabolism

  • Source: Aging cell [Aging Cell] 2024 Sep; Vol. 23 (9), pp. e14212. Date of Electronic Publication: 2024 Jun 02.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.

  • Authors : Yan Y; Department of Neurosurgery, Lanzhou University Second Hospital, No.82, Cuiyingmen, Chengguan District, Lanzhou City, 730030, Gansu Province, China.; Bai S

Subjects: Glioma*/Glioma*/Glioma*/genetics ; Glioma*/Glioma*/Glioma*/pathology ; Glioma*/Glioma*/Glioma*/metabolism

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 May 15; Vol. 22 (1), pp. 272. Date of Electronic Publication: 2024 May 15.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Academic Journal

Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease.

  • Authors : Wang X; Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, No.9, Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226009, China. .; Xie Y

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jun 03; Vol. 16 (1), pp. 121. Date of Electronic Publication: 2024 Jun 03.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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