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Structural identification of a hotspot on CFTR for potentiation.

• Authors : Liu F; Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, NY 10065, USA.; Tri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065, USA.

Subjects: Aminophenols/Aminophenols/Aminophenols/*chemistry ; Chloride Channel Agonists/Chloride Channel Agonists/Chloride Channel Agonists/*chemistry ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*chemistry

• Source: Science (New York, N.Y.) [Science] 2019 Jun 21; Vol. 364 (6446), pp. 1184-1188.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene.

• Authors : Venturini A; Telethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Italy.; Borrelli A

Subjects: Codon, Nonsense*; Aminopyridines/Aminopyridines/Aminopyridines/*pharmacology ; Benzodioxoles/Benzodioxoles/Benzodioxoles/*pharmacology

• Source: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 04; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment.

• Authors : Shaughnessy CA; Department of Pediatrics, National Jewish Health, Denver, CO, USA. .; Zeitlin PL

Subjects: Cystic Fibrosis*/Cystic Fibrosis*/Cystic Fibrosis*/drug therapy ; Cystic Fibrosis*/Cystic Fibrosis*/Cystic Fibrosis*/metabolism; Aminophenols/Aminophenols/Aminophenols/*pharmacology

• Source: Scientific reports [Sci Rep] 2021 Oct 06; Vol. 11 (1), pp. 19810. Date of Electronic Publication: 2021 Oct 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation

• Authors : Phuan, Puay-Wah; Haggie, Peter M; Tan, Joseph A

Subjects: Medical Physiology; Biomedical and Clinical Sciences; Cystic Fibrosis

• Source: Journal of Cystic Fibrosis. 20(3)

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The effectiveness and value of novel treatments for cystic fibrosis.

• Authors : Kuntz, Karen; Wherry, Kael; Seidner, Matt

Subjects: Adolescent; Aminophenols; Aminopyridines

• Source: Journal of Managed Care and Specialty Pharmacy. 27(2)

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Structural identification of a hotspot on CFTR for potentiation

• Authors : Liu, Fangyu; Zhang, Zhe; Levit, Anat

Subjects: Lung; Cystic Fibrosis; Rare Diseases1184 - 1188

• Source: Science, vol 364, iss 6446

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The Effect of Elexacaftor/Tezacaftor/Ivacaftor on Hospitalizations and Intravenous Antibiotic Use

• Authors : Eric, Walter; Jennifer L, Bass

Subjects: Indoles; Pyrrolidines; Cystic Fibrosis

• Source: Perm J

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Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene

• Authors : Mario Renda; Paolo Scudieri; Luis J. V. Galietta ...

Subjects: chloride channel; Pyrrolidines; QH301-705.5

• Source: International Journal of Molecular SciencesVolume 22Issue 21International Journal of Molecular Sciences, Vol 22, Iss 11972, p 11972 (2021)

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Kystisen fibroosin uudistuva lääkehoito

• Authors : Malmivaara, Kirsi; Elenius, Varpu;

Subjects: Cystic Fibrosis; +drug therapy; +genetics

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Structural identification of a hotspot on CFTR for potentiation

• Authors : Anat Levit; Brian K. Shoichet; Jesper Levring

Subjects: Protein Folding; Cystic Fibrosis; Investigational

• Source: Science (New York, N.Y.), vol 364, iss 6446

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