Authors : Cremer T; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands.

Subjects: Autoantigens*/Autoantigens*/Autoantigens*/metabolism ; Autoantigens*/Autoantigens*/Autoantigens*/immunology ; Endoplasmic Reticulum-Associated Degradation*

Source: PloS one [PLoS One] 2024 May 24; Vol. 19 (5), pp. e0287877. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review).

Authors : Huang J; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co‑Constructed by Henan Province and Education Ministry of People's Republic of China, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China.; Wang J

Subjects: Chaperone-Mediated Autophagy* ; Homeostasis* ; Proteolysis*

Source: Molecular medicine reports [Mol Med Rep] 2025 Jan; Vol. 31 (1). Date of Electronic Publication: 2024 Nov 08.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction.

Authors : Raj A; Department of Biophysics, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru, Karnataka, 560029, India.; Banerjee R

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Astrocytes*/Astrocytes*/Astrocytes*/metabolism ; Dopaminergic Neurons*/Dopaminergic Neurons*/Dopaminergic Neurons*/metabolism

Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Dec 02; Vol. 22 (1), pp. 574. Date of Electronic Publication: 2024 Dec 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms.

Authors : Rokad D; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.; Harischandra DS

Subjects: Exosomes*/Exosomes*/Exosomes*/metabolism ; Manganese*/Manganese*/Manganese*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 14; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy.

Authors : Vukovic D; Department of Biochemistry, University of Zurich, 8057, Zurich, Switzerland.; Winkelvoß D

Subjects: Microscopy, Fluorescence*/Microscopy, Fluorescence*/Microscopy, Fluorescence*/methods ; Proteolysis* ; Microinjections*/Microinjections*/Microinjections*/methods

Source: Scientific reports [Sci Rep] 2024 Nov 07; Vol. 14 (1), pp. 27153. Date of Electronic Publication: 2024 Nov 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function.

Authors : Riutin M; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot P.O. Box 26, Israel.; Erez P

Subjects: Cyclin-Dependent Kinase Inhibitor p21*/Cyclin-Dependent Kinase Inhibitor p21*/Cyclin-Dependent Kinase Inhibitor p21*/metabolism ; Cyclin-Dependent Kinase Inhibitor p21*/Cyclin-Dependent Kinase Inhibitor p21*/Cyclin-Dependent Kinase Inhibitor p21*/genetics ; Proteolysis*

Source: Cells [Cells] 2024 Oct 09; Vol. 13 (19). Date of Electronic Publication: 2024 Oct 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).

Authors : Ortiz Zacarías NV; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2333 CC Leiden, The Netherlands.; Röth S

Subjects: Receptors, CCR2*/Receptors, CCR2*/Receptors, CCR2*/metabolism ; Proteolysis*/Proteolysis*/Proteolysis*/drug effects ; Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/Proteasome Endopeptidase Complex*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 18; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome.

Authors : Poliquin S; Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.

Subjects: Epilepsies, Myoclonic*/Epilepsies, Myoclonic*/Epilepsies, Myoclonic*/metabolism ; Epilepsies, Myoclonic*/Epilepsies, Myoclonic*/Epilepsies, Myoclonic*/genetics ; Receptors, GABA-A*/Receptors, GABA-A*/Receptors, GABA-A*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 23; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia.

Authors : Vinopalová M; Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Prague, Czech Republic.; Arbonová L

Subjects: Protozoan Proteins*/Protozoan Proteins*/Protozoan Proteins*/metabolism ; Protozoan Proteins*/Protozoan Proteins*/Protozoan Proteins*/genetics ; Giardia lamblia*/Giardia lamblia*/Giardia lamblia*/metabolism

Source: PLoS pathogens [PLoS Pathog] 2024 Oct 21; Vol. 20 (10), pp. e1012617. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.

Authors : Tejwani V; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, DD1 5EH, UK.; Carroll T

Subjects: Werner Syndrome Helicase*/Werner Syndrome Helicase*/Werner Syndrome Helicase*/metabolism ; Werner Syndrome Helicase*/Werner Syndrome Helicase*/Werner Syndrome Helicase*/genetics ; Microsatellite Instability*/Microsatellite Instability*/Microsatellite Instability*/drug effects

Source: Scientific reports [Sci Rep] 2024 Sep 06; Vol. 14 (1), pp. 20824. Date of Electronic Publication: 2024 Sep 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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نتائج البحث

فلترة النتائج

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2.

Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review).

Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction.

Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms.

Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy.

Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function.

Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).

Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome.

Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia.

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.

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