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  • 1-10 ل  546 نتائج ل ""Ubiquitin-Protein Ligases""
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Academic Journal

Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges.

  • Authors : Wang C; The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China.; Zhang Y

Subjects: Proteins*/Proteins*/Proteins*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Intercellular Signaling Peptides and Proteins

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1667-1693.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling.

  • Authors : Kausas M; New Hunt's House, King's College London, Guy's Campus, London, SE1 1UL, UK.; Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

Subjects: Proteins*/Proteins*/Proteins*/chemistry ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism; Molecular Dynamics Simulation

  • Source: Scientific reports [Sci Rep] 2022 Sep 08; Vol. 12 (1), pp. 15201. Date of Electronic Publication: 2022 Sep 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A guide to UFMylation, an emerging posttranslational modification.

  • Authors : Millrine D; Medical Research Council Protein Phosphorylation & Ubiquitylation Unit (MRC-PPU), School of Life Sciences, University of Dundee, UK.; Peter JJ

Subjects: Proteins*/Proteins*/Proteins*/metabolism ; Protein Processing, Post-Translational*; Humans

  • Source: The FEBS journal [FEBS J] 2023 Nov; Vol. 290 (21), pp. 5040-5056. Date of Electronic Publication: 2023 Feb 08.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

The Post-Translational Role of UFMylation in Physiology and Disease.

  • Authors : Wang X; Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.; Xu X

Subjects: Proteins*/Proteins*/Proteins*/metabolism ; Protein Processing, Post-Translational*; Animals

  • Source: Cells [Cells] 2023 Oct 29; Vol. 12 (21). Date of Electronic Publication: 2023 Oct 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders.

  • Authors : Brixi G; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Ye T

Subjects: Proteins* ; Peptides*/Peptides*/Peptides*/metabolism; Amino Acid Sequence

  • Source: Communications biology [Commun Biol] 2023 Oct 24; Vol. 6 (1), pp. 1081. Date of Electronic Publication: 2023 Oct 24.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Emerging Strategies in Proteolysis-Targeting Chimeras (PROTACs): Highlights from 2022.

  • Authors : Tamatam R; College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea.; Gachon Pharmaceutical Research Institute, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea.

Subjects: Proteins*/Proteins*/Proteins*/chemistry ; Neoplasms*; Humans

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 08; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Parkin coregulates glutathione metabolism in adult mammalian brain.

  • Authors : El Kodsi DN; Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.

Subjects: Glutathione*/Glutathione*/Glutathione*/metabolism ; Proteins*/Proteins*/Proteins*/metabolism; Adult

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jan 23; Vol. 11 (1), pp. 19. Date of Electronic Publication: 2023 Jan 23.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway.

  • Authors : Wang B; Department of Neurosurgery, Tianjin Huanhu Hospital; Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative diseases, Tianjin Neurosurgical Institute, No. 6 Jizhao Road, Tianjin, 300350, China.

Subjects: Cell Movement/Cell Movement/Cell Movement/*genetics ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*genetics ; Glioma/Glioma/Glioma/*genetics

  • Source: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2020 Apr; Vol. 43 (2), pp. 223-235. Date of Electronic Publication: 2019 Nov 27.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH.

  • Authors : Bhattacharya A; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Graduate Program of Genetics, Genomics and Development, Cornell University, Ithaca, NY, USA.

Subjects: Endoplasmic Reticulum-Associated Degradation* ; Energy Metabolism*; Cyclic AMP Response Element-Binding Protein/Cyclic AMP Response Element-Binding Protein/Cyclic AMP Response Element-Binding Protein/*metabolism

  • Source: The EMBO journal [EMBO J] 2018 Nov 15; Vol. 37 (22). Date of Electronic Publication: 2018 Nov 02.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cellular Control of Protein Turnover via the Modification of the Amino Terminus.

  • Authors : Winter N; Max Perutz Labs, Department of Biochemistry and Cell Biology, University of Vienna, A-1030 Vienna, Austria.; Novatchkova M

Subjects: Methionyl Aminopeptidases/Methionyl Aminopeptidases/Methionyl Aminopeptidases/*metabolism ; Proteins/Proteins/Proteins/*metabolism ; Ribosomes/Ribosomes/Ribosomes/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 29; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 ل  546 نتائج ل ""Ubiquitin-Protein Ligases""