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Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2.

• Authors : Lotz-Jenne C; Drug discovery, Idorsia Pharmaceuticals Limited, Hegenheimermattweg 91, Allschwil, Basel-Land, 4123, Switzerland. .; Lange R

Subjects: Tryptophan Oxygenase*/Tryptophan Oxygenase*/Tryptophan Oxygenase*/antagonists & inhibitors ; Tryptophan Oxygenase*/Tryptophan Oxygenase*/Tryptophan Oxygenase*/metabolism ; Tryptophan Oxygenase*/Tryptophan Oxygenase*/Tryptophan Oxygenase*/chemistry

• Source: Scientific reports [Sci Rep] 2024 Nov 14; Vol. 14 (1), pp. 27937. Date of Electronic Publication: 2024 Nov 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Computational investigation of cis-1,4-polyisoprene binding to the latex-clearing protein LcpK30.

• Authors : Abu Hassan A; Faculty of Engineering, University of Nottingham, Nottingham, United Kingdom.; Hanževački M

Subjects: Hemiterpenes*/Hemiterpenes*/Hemiterpenes*/metabolism ; Hemiterpenes*/Hemiterpenes*/Hemiterpenes*/chemistry ; Latex*/Latex*/Latex*/chemistry

• Source: PloS one [PLoS One] 2024 May 15; Vol. 19 (5), pp. e0302398. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

• Authors : Hanjing Yang; Josue Pacheco; Kyumin Kim

Subjects: Gene Editing; Models, Molecular; Science

• Source: Nat CommunNature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

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Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

• Authors : Rashid, Ishtiaque; Hammel, Michal; Sverzhinsky, Aleksandr

Subjects: Biochemistry and Cell Biology; Biological Sciences; Genetics

• Source: Journal of Biological Chemistry. 297(2)

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Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach

• Authors : Atul Kumar, Singh; Shashank, Kumar

Subjects: Molecular Docking Simulation; 0301 basic medicine; 0303 health sciences

• Source: Natural Product Research. 37:1851-1855

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Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site.

• Authors : Lacham-Hartman S; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Shmidov Y

Subjects: Models, Molecular* ; Protein Binding*; Binding Sites

• Source: PloS one [PLoS One] 2021 Nov 30; Vol. 16 (11), pp. e0249616. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6

• Authors : Jeremy D. Osko; David W. Christianson

Subjects: Models, Molecular; Protein Conformation, alpha-Helical; 0301 basic medicine

• Source: Acta Crystallographica Section F Structural Biology Communications. 76:428-437

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The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

• Authors : Mysling, Simon; Kristensen, Kristian Kølby; Larsson, Mikael

Subjects: Cell Line; Animals; Humans

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Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

• Authors : Byeon, In-Ja L; Byeon, Chang-Hyeock; Wu, Tiyun

Subjects: Biochemistry and Cell Biology; Biological Sciences; Genetics

• Source: Biochemistry. 55(21)

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RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain

• Authors : Nunzio Bottini; Eugenio Santelli; Mattias Svensson

Subjects: Models, Molecular; 0301 basic medicine; Protein Conformation

• Source: Journal of Biological Chemistry. 295:4923-4936

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