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Academic Journal

Association of Intergenic and Intragenic MGMT Enhancer Methylation with MGMT Promoter Methylation, MGMT Protein Expression and Clinical and Demographic Parameters in Glioblastoma.

  • Authors : Pühringer K; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.; Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, 1090 Vienna, Austria.

Subjects: DNA Methylation* ; DNA Modification Methylases*/DNA Modification Methylases*/DNA Modification Methylases*/genetics ; DNA Modification Methylases*/DNA Modification Methylases*/DNA Modification Methylases*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 04; Vol. 26 (7). Date of Electronic Publication: 2025 Apr 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Accurate and comprehensive evaluation of O6-methylguanine-DNA methyltransferase promoter methylation by nanopore sequencing.

  • Authors : Halldorsson S; Vilhelm Magnus Laboratory, Institute for Surgical Research, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.; Nagymihaly RM

Subjects: DNA Methylation* ; Nanopore Sequencing*/Nanopore Sequencing*/Nanopore Sequencing*/methods ; Promoter Regions, Genetic*/Promoter Regions, Genetic*/Promoter Regions, Genetic*/genetics

  • Source: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2024 Jun; Vol. 50 (3), pp. e12984.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7609829 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The TERT promoter mutation status and MGMT promoter methylation status, combined with dichotomized MRI-derived and clinical features, predict adult primary glioblastoma survival.

  • Authors : Shu C; School of Medicine, Nankai University, Tianjin, China.; Wang Q

Subjects: DNA Methylation* ; Magnetic Resonance Imaging*/Magnetic Resonance Imaging*/Magnetic Resonance Imaging*/methods ; Mutation*

  • Source: Cancer medicine [Cancer Med] 2018 Aug; Vol. 7 (8), pp. 3704-3712. Date of Electronic Publication: 2018 Jul 09.Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

MGMT gene promoter methylation in humoral tissue as biomarker for lung cancer diagnosis: An update meta-analysis.

  • Authors : Chen B; Department of Radiotherapy, Lishui Central Hospital, Lishui, Zhejiang Province, China.; Ying X

Subjects: Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*genetics ; Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*genetics ; DNA Methylation/DNA Methylation/DNA Methylation/*genetics

  • Source: Thoracic cancer [Thorac Cancer] 2021 Dec; Vol. 12 (23), pp. 3194-3200. Date of Electronic Publication: 2021 Oct 15.Publisher: Wiley Publishing Asia Pty Ltd Country of Publication: Singapore NLM ID: 101531441 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the MGMT Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set.

  • Authors : Zappe K; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.; Pirker C

Subjects: High-Throughput Nucleotide Sequencing*; DNA Modification Methylases/DNA Modification Methylases/DNA Modification Methylases/*genetics ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 20; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

High-dose radiotherapy in newly diagnosed low-grade gliomas with nonmethylated O(6)-methylguanine-DNA methyltransferase.

  • Authors : Liu Y; Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, People's Republic of China.; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, People's Republic of China.

Subjects: DNA Methylation* ; Promoter Regions, Genetic*; Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*radiotherapy

  • Source: Radiation oncology (London, England) [Radiat Oncol] 2021 Aug 19; Vol. 16 (1), pp. 157. Date of Electronic Publication: 2021 Aug 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X

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Academic Journal

Combination chemoradiotherapy with temozolomide, vincristine, and interferon-β might improve outcomes regardless of O6-methyl-guanine-DNA-methyltransferase (MGMT) promoter methylation status in newly glioblastoma.

  • Authors : Asano K; Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. .; Fumoto T

Subjects: Chemoradiotherapy*/Chemoradiotherapy*/Chemoradiotherapy*/methods ; DNA Methylation* ; Promoter Regions, Genetic*

  • Source: BMC cancer [BMC Cancer] 2021 Jul 28; Vol. 21 (1), pp. 867. Date of Electronic Publication: 2021 Jul 28.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Academic Journal

The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents.

  • Authors : Siller S; Department of Neurosurgery, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. .; German Cancer Consortium (DKTK), Partner Site Munich, Pettenkoferstrasse 8a, 80336, Munich, Germany. .

Subjects: CpG Islands* ; DNA Methylation* ; Promoter Regions, Genetic*

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Mar 04; Vol. 9 (1), pp. 35. Date of Electronic Publication: 2021 Mar 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma.

  • Authors : Hanihara M; Departments of Neurosurgery, University of Yamanashi, Chuo, Yamanashi, Japan.; Miyake K

Subjects: Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/*methods ; DNA Modification Methylases/DNA Modification Methylases/DNA Modification Methylases/*genetics ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*genetics

  • Source: Clinical epigenetics [Clin Epigenetics] 2020 Nov 17; Vol. 12 (1), pp. 174. Date of Electronic Publication: 2020 Nov 17.Publisher: Biomed Central Country of Publication: Germany NLM ID: 101516977 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-7083

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Academic Journal

Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II.

  • Authors : Karschnia P; Division of Neuro-Oncology, Department of Neurosurgery, Ludwig Maximilians University School of Medicine, Marchioninistrasse 15, 81377, Munich, Germany. .; German Cancer Consortium (DKTK), Partner Site, Munich, Germany. .

Subjects: DNA Methylation* ; Gene Expression Regulation, Neoplastic* ; Mutation*

  • Source: Scientific reports [Sci Rep] 2020 Nov 12; Vol. 10 (1), pp. 19758. Date of Electronic Publication: 2020 Nov 12.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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