نتائج البحث

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors

• Authors : Franciosa, Giulia; Olsen, Jesper V

Subjects: Humans; Phosphorylation; Cell Line

• Source: Franciosa , G & Olsen , J V 2023 , ' Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2

تفاصيل العنوان

Combining structure-based pharmacophore modeling and machine learning for the identification of novel BTK inhibitors

• Authors : Tanuj Sharma; Venu Venkatarame Gowda Saralamma; Duk Chul Lee

Subjects: Agammaglobulinaemia Tyrosine Kinase; Humans; Machine Learning

تفاصيل العنوان

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

• Authors : Jones, Mathew J K; Gelot, Camille; Munk, Stephanie

Subjects: Adaptor Proteins; Signal Transducing/genetics; Animals

• Source: Jones , M J K , Gelot , C , Munk , S , Koren , A , Kawasoe , Y , George , K A , Santos , R E , Olsen , J V , McCarroll , S A , Frattini , M G , Takahashi , T S & Jallepalli , P V 2021 , ' Human DDK

تفاصيل العنوان

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

• Authors : Fan, Ying; Howden, Andrew J. M.; Sarhan, Adil R.

Subjects: Animals; Antibodies; Monoclonal/chemistry

• Source: Fan , Y , Howden , A J M , Sarhan , A R , Lis , P , Ito , G , Martinez , T N , Brockmann , K , Gasser , T , Alessi , D R & Sammler , E 2018 , ' Interrogating Parkinson's disease LRRK2

تفاصيل العنوان

Phosphorylation of Serine 148 in Giardia lamblia End-binding 1 Protein is Important for Cell Division

• Authors : College of Medicine; Dept. of Environmental Medical Biology; Juri Kim

Subjects: Aurora Kinases/metabolism; Cytokinesis/drug effects; Cytoskeletal Proteins/genetics

تفاصيل العنوان

CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to Palbociclib

• Authors : Raspé, Eric; Coulonval, Katia; Pita, Jaime Miguel

Subjects: Sciences biomédicales en général; Antineoplastic Agents -- pharmacology; Breast Neoplasms -- pathology

• Source: EMBO molecular medicine, 9 (8

تفاصيل العنوان

CK2 phosphorylation of C/EBPdelta regulates its transcription factor activity.

• Authors : Schwind, Lisa; Zimmer, Andreas David; Gotz, Claudia

Subjects: Amino Acid Sequence; CCAAT-Enhancer-Binding Protein-delta/genetics/metabolism; Casein Kinase II/antagonists & inhibitors/genetics/metabolism

• Source: The international journal of biochemistry & cell biology, 61, 81-9 (2015)

تفاصيل العنوان

DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells.

• Authors : Shinichiro Fukuhara; Inik Chang; Yozo Mitsui

Subjects: Adaptor Proteins; Signal Transducing/biosynthesis; Signal Transducing/genetics

• Source: T201404833.pdf

تفاصيل العنوان

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-beta type 1 receptor kinase inhibitors

• Authors : College of Medicine; Yonsei Biomedical Research Center; Maddeboina Krishnaiah

Subjects: Cell Line; Transformed; Enzyme Assays

تفاصيل العنوان

γ-Actin regulates cell migration and modulates the ROCK signaling pathway

• Authors : Shum, Michael S Y; Pasquier, Eddy; Po'uha, Sela T

Subjects: info:eu-repo/classification/ddc/616.07; Actins/antagonists & inhibitors/genetics/metabolism; Amides/pharmacology

• Source: ISSN: 0892-6638 ; The FASEB journal, vol. 25, no. 12 (2011) p. 4423-4433.

تفاصيل العنوان