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Sterol–lipids enable large-scale, liquid–liquid phase separation in bilayer membranes of only two components

• Authors : Wilson, Kent J; Nguyen, Huy Q; Gervay-Hague, Jacquelyn

Subjects: Biochemistry and Cell Biology; Physical Sciences; Biological Sciences

• Source: Proceedings of the National Academy of Sciences of the United States of America. 121(38)

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A sequence-based model for identifying proteins undergoing liquid-liquid phase separation/forming fibril aggregates via machine learning.

• Authors : Liao S; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; Zhang Y

Subjects: Phase Separation* ; Intrinsically Disordered Proteins*/Intrinsically Disordered Proteins*/Intrinsically Disordered Proteins*/chemistry; Amyloid/Amyloid/Amyloid/chemistry

• Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 Mar; Vol. 33 (3), pp. e4927.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.

• Authors : Kaizuka T; RIKEN Brain Science Institute, Wako, Saitama, Japan.; Department of Physiology and Cell Biology, Kobe University School of Medicine, Kobe, Chuo, Kobe, Japan.

Subjects: Proteome*/Proteome*/Proteome*/metabolism ; Phase Separation*; Disks Large Homolog 4 Protein/Disks Large Homolog 4 Protein/Disks Large Homolog 4 Protein/metabolism

• Source: PLoS biology [PLoS Biol] 2024 Mar 07; Vol. 22 (3), pp. e3002006. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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MLOsMetaDB, a meta-database to centralize the information on liquid-liquid phase separation proteins and membraneless organelles.

• Authors : Orti F; Leloir Institute/IIBBA, Buenos Aires, Argentina.; Fernández ML

Subjects: Biomolecular Condensates* ; Phase Separation*; Proteins/Proteins/Proteins/metabolism

• Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 Jan; Vol. 33 (1), pp. e4858.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation.

• Authors : Jin, Gaowei^1,2,3 (AUTHOR); Campos, Joaquín⁴ (AUTHOR); Liu, Yang^1,2,3 (AUTHOR)

• Source: PLoS Biology. 6/10/2025, Vol. 23 Issue 6, p1-29. 29p.

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Mesoscale properties of protein clusters determine the size and nature of liquid-liquid phase separation (LLPS).

• Authors : Golani, Gonen^1,2 (AUTHOR) ; Seal, Manas² (AUTHOR); Kar, Mrityunjoy^3,4 (AUTHOR)

• Source: Communications Physics. 6/2/2025, Vol. 8 Issue 1, p1-10. 10p.

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Yield of Protein Crystallization from Metastable Liquid–Liquid Phase Separation.

• Authors : Thomas, Shamberia¹ (AUTHOR); Dougay, Joel A.¹ (AUTHOR); Annunziata, Onofrio¹ (AUTHOR)

Subjects: *Phase separation; *Crystallization; *Biotechnology

• Source: Molecules. Jun2025, Vol. 30 Issue 11, p2371. 14p.

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液-液相分离在动脉粥样硬化中的关键作用.

• Authors : 赵方尧^1,2 ; 李俊豪²; 杨 科^1,2

• Source: Chinese Journal of Arteriosclerosis. Mar2025, Vol. 33 Issue 3, p185-201. 10p.

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The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases.

• Authors : Xingyu Lu¹; Jiongtong Lu¹; Shengnan Li¹

• Source: Aging & Disease. Apr2025, Vol. 16 Issue 2, p769-786. 18p.

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Role of liquid–liquid phase separation in cancer: Mechanisms and therapeutic implications.

• Authors : Li, Xuesong¹ (AUTHOR); Yu, Zhuo² (AUTHOR)

• Source: Cancer Innovation. Oct2024, Vol. 3 Issue 5, p1-13. 13p.

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