نتائج البحث

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.

• Authors : Yamada K; RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.; Hildebrand S

Subjects: Huntington Disease/Huntington Disease/Huntington Disease/*genetics ; Oligonucleotides/Oligonucleotides/Oligonucleotides/*metabolism ; RNA, Small Interfering/RNA, Small Interfering/RNA, Small Interfering/*metabolism

• Source: Nucleic acids research [Nucleic Acids Res] 2021 Dec 02; Vol. 49 (21), pp. 12069-12088.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

تفاصيل العنوان

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.

• Authors : Hassler, Matthew R¹; Turanov, Anton A¹; Alterman, Julia F¹

• Source: Nucleic Acids Research. 3/16/2018, Vol. 46 Issue 5, p2185-2196. 12p. 1 Color Photograph, 3 Graphs.

تفاصيل العنوان

A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo.

• Authors : Coles, Andrew H.^1,2; Osborn, Maire F.^1,2; Alterman, Julia F.^1,2

Subjects: *GENE silencing; *OLIGONUCLEOTIDES; *POLYMERASE chain reaction

• Source: Nucleic Acid Therapeutics. Apr2016, Vol. 26 Issue 2, p86-92. 7p.

تفاصيل العنوان