نتائج البحث

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.

• Authors : Fernandez A; Program in Solid Tumors, CIMA, Cancer Center Clinica Universidad de Navarra (CCUN), University of Navarra, Avenida de Pio XII, 55, 31008 Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, 31008 Pamplona, Spain.

Subjects: DNA Damage* ; Checkpoint Kinase 2*/Checkpoint Kinase 2*/Checkpoint Kinase 2*/metabolism ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism

• Source: Cells [Cells] 2025 May 20; Vol. 14 (10). Date of Electronic Publication: 2025 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets.

• Authors : Khamidullina AI; Laboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.

Subjects: DNA Damage* ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid Tumors

• Source: A Phase I Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid

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The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer.

• Authors : Andrade-Tomaz M; Departamento de Oncologia Clínica e Experimental, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04037-003, SP, Brazil.; de Souza I

Subjects: Gene Expression Regulation, Neoplastic*; Carcinogenesis/Carcinogenesis/Carcinogenesis/*genetics ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*genetics

• Source: Cells [Cells] 2020 Sep 22; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.

• Authors : Wayne J; Vernalis (R&D) Ltd, Cambridge, UK.; Brooks T

Subjects: DNA Damage* ; Immunity, Innate* ; Signal Transduction*

• Source: The FEBS journal [FEBS J] 2021 Aug; Vol. 288 (15), pp. 4507-4540. Date of Electronic Publication: 2021 Feb 18.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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P90 ribosomal S6 kinase confers cancer cell survival by mediating checkpoint kinase 1 degradation in response to glucose stress

• Authors : Ying Ma; Danrui Cui; Linchen Wang

Subjects: 0301 basic medicine; Cell Survival; Pteridines

• Source: Cancer Sci

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Targeting Non-Oncogene Addiction for Cancer Therapy.

• Authors : Chang HR; Department of Biological Sciences and Research Institute of Women's Health, Sookmyung Women's University, Seoul 04310, Korea.; Jung E

Subjects: Oncogenes*; Neoplasms/Neoplasms/Neoplasms/*genetics ; Neoplasms/Neoplasms/Neoplasms/*therapy

• Source: Biomolecules [Biomolecules] 2021 Jan 20; Vol. 11 (2). Date of Electronic Publication: 2021 Jan 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.

• Authors : González Besteiro MA; Fundación Instituto Leloir - Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.; Calzetta NL

Subjects: DNA Replication*; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*genetics ; Gene Knockdown Techniques/Gene Knockdown Techniques/Gene Knockdown Techniques/*methods

• Source: The EMBO journal [EMBO J] 2019 Aug 15; Vol. 38 (16), pp. e101284. Date of Electronic Publication: 2019 Jul 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway.

• Authors : Majera D; Laboratory of Genome Integrity, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77 147 Olomouc, Czech Republic.; Skrott Z

Subjects: Alcohol Deterrents/Alcohol Deterrents/Alcohol Deterrents/*pharmacology ; Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors ; DNA Damage/DNA Damage/DNA Damage/*drug effects

• Source: Cells [Cells] 2020 Feb 18; Vol. 9 (2). Date of Electronic Publication: 2020 Feb 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Claspin - checkpoint adaptor and DNA replication factor.

• Authors : Smits VAJ; Hospital Universitario de Canarias, Unidad de Investigación, La Laguna, Tenerife, Spain.; Facultad de Medicina, Instituto de Tecnologías Biomédicas, Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna, Tenerife, Spain.

Subjects: DNA Replication* ; Gene Expression Regulation, Neoplastic*; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*genetics

• Source: The FEBS journal [FEBS J] 2019 Feb; Vol. 286 (3), pp. 441-455. Date of Electronic Publication: 2018 Jun 29.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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