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Academic Journal

Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis.

  • Authors : Sharma A; Centre for Tuberculosis Research, Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad-Gurugram expressway, Faridabad, Haryana, India.; Singh N

Subjects: Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/genetics ; Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/metabolism ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/metabolism

  • Source: Communications biology [Commun Biol] 2024 Oct 30; Vol. 7 (1), pp. 1417. Date of Electronic Publication: 2024 Oct 30.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Distribution of lineages and type II toxin-antitoxin systems among rifampin-resistant Mycobacterium Tuberculosis Isolates.

  • Authors : Shafipour M; Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran.; Mohammadzadeh A

Subjects: Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/genetics ; Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/Mycobacterium tuberculosis*/drug effects ; Toxin-Antitoxin Systems*/Toxin-Antitoxin Systems*/Toxin-Antitoxin Systems*/genetics

  • Source: PloS one [PLoS One] 2024 Oct 24; Vol. 19 (10), pp. e0309292. Date of Electronic Publication: 2024 Oct 24 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Long Dynamic β1-β2 Loops in M. tb MazF Toxins Affect the Interaction Modes and Strengths of the Toxin-Antitoxin Pairs.

  • Authors : Tang Z; MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.; Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

Subjects: Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/chemistry ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/metabolism ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 05; Vol. 25 (17). Date of Electronic Publication: 2024 Sep 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin-Antitoxin Systems.

Subjects: Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/chemistry ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/genetics ; Bacterial Toxins*/Bacterial Toxins*/Bacterial Toxins*/chemistry

  • Source: Toxins [Toxins (Basel)] 2020 Jul 29; Vol. 12 (8). Date of Electronic Publication: 2020 Jul 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651

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Academic Journal

Multi-Stress Induction of the Mycobacterium tuberculosis MbcTA Bactericidal Toxin-Antitoxin System.

  • Authors : Ariyachaokun K; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France.; Department of Biological Science, Ubon Ratchathani University, 85 Sathollmark Rd., Warin Chamrab, Ubon Ratchathani 34190, Thailand.

Subjects: Gene Expression Regulation, Bacterial*/Gene Expression Regulation, Bacterial*/Gene Expression Regulation, Bacterial*/drug effects ; Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects; Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*genetics

  • Source: Toxins [Toxins (Basel)] 2020 May 16; Vol. 12 (5). Date of Electronic Publication: 2020 May 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651

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Academic Journal

Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.

  • Authors : Yu X; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, 101149, Beijing, China.

Subjects: Toxin-Antitoxin Systems*; Antitoxins/Antitoxins/Antitoxins/*metabolism ; Bacterial Toxins/Bacterial Toxins/Bacterial Toxins/*metabolism

  • Source: Communications biology [Commun Biol] 2020 May 07; Vol. 3 (1), pp. 216. Date of Electronic Publication: 2020 May 07.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Genome-wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin-antitoxin systems as a major substrate class.

  • Authors : Ziemski M; Institute of Molecular Biology & Biophysics, ETH Zurich, Switzerland.; Leodolter J

Subjects: Gene Expression Regulation, Bacterial*; Antitoxins/Antitoxins/Antitoxins/*genetics ; Bacterial Toxins/Bacterial Toxins/Bacterial Toxins/*genetics

  • Source: The FEBS journal [FEBS J] 2021 Jan; Vol. 288 (1), pp. 111-126. Date of Electronic Publication: 2020 May 12.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair.

  • Authors : Tandon H; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.; Sharma A

Subjects: Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*genetics ; Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*metabolism ; Mycobacterium tuberculosis/Mycobacterium tuberculosis/Mycobacterium tuberculosis/*genetics

  • Source: Scientific reports [Sci Rep] 2019 Feb 04; Vol. 9 (1), pp. 1163. Date of Electronic Publication: 2019 Feb 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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