نتائج البحث

Toxicity of ALS-linked SOD1 mutants.

• Authors : Williamson TL; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.; Corson LB

Subjects: Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/*enzymology ; Motor Neurons/Motor Neurons/Motor Neurons/*pathology ; Superoxide Dismutase/Superoxide Dismutase/Superoxide Dismutase/*genetics

• Source: Science (New York, N.Y.) [Science] 2000 Apr 21; Vol. 288 (5465), pp. 399.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons.

• Authors : Williamson TL; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla 92093, USA.; Cleveland DW

Subjects: Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/*genetics ; Axonal Transport/Axonal Transport/Axonal Transport/*physiology ; Motor Neurons/Motor Neurons/Motor Neurons/*physiology

• Source: Nature neuroscience [Nat Neurosci] 1999 Jan; Vol. 2 (1), pp. 50-6.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print Cited Medium: Print ISSN:

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SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

• Authors : Trotti, Davide; Rolfs, Andreas; Danbolt, Niels C.

• Source: Nature Neuroscience. May99, Vol. 2 Issue 5, p427. 7p.

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Interaction between Familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 Mutants and the Dynein Complex

• Authors : Sangmook Lee; Fujian Zhang; Kei Fukada

Subjects: Proteomics; animal diseases; Mutant

• Source: Journal of Biological Chemistry. 282:16691-16699

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Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS

• Authors : Steven A. Goldman; Joy A. Umbach; Saravanan Karumbayaram

Subjects: Research Report; Cell type; Time Factors

• Source: Disease Models & Mechanisms. 2:189-195

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Mechanism and treatment of motoneuron degeneration in ALS: What have SOD1 mutants told us?

• Authors : Zuoshang Xu

Subjects: Motor Neurons; Mutation; Superoxide Dismutase

• Source: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 1:225-234

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Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

• Authors : Anna-Lena Ström; Haining Zhu; Ping Shi

Subjects: SOD1; Dynein; Kinesins

• Source: Biochimica et biophysica acta. 1802(9)

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ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

• Authors : Konstantin Stojanovic; Berislav V. Zlokovic; M. Kerry O'Banion

Subjects: Nervous system; Endothelium; SOD1

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Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease

• Authors : Pico Caroni; Maria Maddalena Lino; Corinna Schneider

Subjects: Genetically modified mouse; Pathology; medicine.medical_specialty

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Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

• Authors : Séverine Boillée; Christian S. Lobsiger; Don W. Cleveland

Subjects: Aging; Mutant; SOD1

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