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  • 1-10 ل  53 نتائج ل ""Cytochrome P-450 CYP3A Inhibitors""

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Subject : microsomes, liver
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Academic Journal

Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting.

  • Authors : Pham C; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.; Nagar S

Subjects: Hepatocytes* ; Microsomes, Liver*; Troleandomycin/Troleandomycin/Troleandomycin/*metabolism

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1301-1310. Date of Electronic Publication: 2020 Aug 24.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.

  • Authors : Zhang QH; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, Beijing 100050, China.; Hu JP

Subjects: Capsaicin*/Capsaicin*/Capsaicin*/administration & dosage ; Capsaicin*/Capsaicin*/Capsaicin*/analogs & derivatives ; Capsaicin*/Capsaicin*/Capsaicin*/chemistry

  • Source: Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (4), pp. 382-95.Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print Cited Medium: Internet ISSN: 1477-2213

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Academic Journal

Inhibition of CYP3A4 and CYP2C9 by podophyllotoxin: implication for clinical drug-drug interactions.

  • Authors : Song JH; Orthopedics Department 2, Affiliated Zhongshan Hospital of Dalian University, Dalian 116 001, China.; Sun DX

Subjects: Cytochrome P-450 CYP3A Inhibitors*; Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*pharmacology ; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors

  • Source: Journal of biosciences [J Biosci] 2011 Dec; Vol. 36 (5), pp. 879-85.Publisher: Springer India, in co-publication with Indian Academy of Sciences Country of Publication: India NLM ID: 8100809 Publication Model: Print Cited

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Academic Journal

Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.

  • Authors : Nishiya Y; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo 140-8710, Japan. ; Nakamura K

Subjects: Cytochrome P-450 CYP3A Inhibitors*; Diazepam/Diazepam/Diazepam/*pharmacology ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*enzymology

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2010 Jan; Vol. 40 (1), pp. 1-8.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print Cited Medium: Internet ISSN: 1366-5928

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Academic Journal

Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development.

  • Authors : Mori K; Drug Metabolism and Pharmacokinetic Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Toda, Japan.; Hashimoto H

Subjects: Cytochrome P-450 CYP2D6 Inhibitors* ; Cytochrome P-450 CYP3A Inhibitors*; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2009 Jun; Vol. 39 (6), pp. 415-22.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print Cited Medium: Internet ISSN: 1366-5928

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Academic Journal

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

  • Authors : He K; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, PO Box 4000, Princeton, New Jersey 08543-4000, USA.; Qian M

Subjects: Cytochrome P-450 CYP3A Inhibitors* ; Drug Design* ; Microsomes, Liver*/Microsomes, Liver*/Microsomes, Liver*/drug effects

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2008 Jul; Vol. 97 (7), pp. 2568-80.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Internet ISSN: 1520-6017

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Academic Journal

In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes.

  • Authors : Liu L; a Department of Endocrinology , Seventh People's Hospital of Shanghai University of TCM , Shanghai , China.; Sun S

Subjects: Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/Anti-Inflammatory Agents, Non-Steroidal/*pharmacology ; Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*pharmacology ; Cytochrome P-450 CYP2D6 Inhibitors/Cytochrome P-450 CYP2D6 Inhibitors/Cytochrome P-450 CYP2D6 Inhibitors/*pharmacology

  • Source: Pharmaceutical biology [Pharm Biol] 2017 Dec; Vol. 55 (1), pp. 1868-1874.Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116

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Academic Journal

The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism.

  • Authors : Wang X; a Department of General Surgery , Qianfoshan Hospital affiliated to Shandong University , Shandong , China.; Zhang X

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacokinetics ; Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*pharmacology ; Diterpenes/Diterpenes/Diterpenes/*pharmacology

  • Source: Pharmaceutical biology [Pharm Biol] 2017 Dec; Vol. 55 (1), pp. 1863-1867.Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116

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Academic Journal

Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib.

  • Authors : Khan MS; a Discipline of Pharmacology, School of Medical Sciences, University of Adelaide , Adelaide , Australia and.; Barratt DT

Subjects: Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/Cytochrome P-450 CYP2C8/*genetics ; Cytochrome P-450 CYP3A Inhibitors/Cytochrome P-450 CYP3A Inhibitors/Cytochrome P-450 CYP3A Inhibitors/*pharmacokinetics ; Imatinib Mesylate/Imatinib Mesylate/Imatinib Mesylate/*pharmacokinetics

  • Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2016; Vol. 46 (3), pp. 278-87. Date of Electronic Publication: 2015 Jul 10.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes.

  • Authors : Basheer L; Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.; Schultz K

Subjects: Computational Biology/Computational Biology/Computational Biology/*methods ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*chemistry ; Cytochrome P-450 CYP3A Inhibitors/Cytochrome P-450 CYP3A Inhibitors/Cytochrome P-450 CYP3A Inhibitors/*pharmacology

  • Source: PloS one [PLoS One] 2015 Oct 20; Vol. 10 (10), pp. e0141061. Date of Electronic Publication: 2015 Oct 20 (Print Publication: 2015).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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  • 1-10 ل  53 نتائج ل ""Cytochrome P-450 CYP3A Inhibitors""