نتائج البحث

Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimers disease.

• Authors : Leitão, André; Ahammad, Rijwan; Spencer, Brian

Subjects: Alpha synuclein; Alzheimers disease; Amyloid beta

تفاصيل العنوان

The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration.

• Authors : Jafar-Nejad P; Ionis Pharmaceuticals Inc. Carlsbad, CA 92010, USA.; Powers B

Subjects: Central Nervous System/Central Nervous System/Central Nervous System/*chemistry ; Mice/Mice/Mice/*metabolism ; Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*pharmacokinetics

• Source: Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 657-673.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

تفاصيل العنوان

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment

• Authors : Feichtenschlager, Valentin; Zheng, Yixuan James; Ho, Wilson

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Genetics

• Source: Oncotarget. 14(1)

تفاصيل العنوان

Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research.

• Authors : Sigmon JS; Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599.; Blanchard MW

Subjects: Genome-Wide Association Study/Genome-Wide Association Study/Genome-Wide Association Study/*methods ; Genotyping Techniques/Genotyping Techniques/Genotyping Techniques/*methods ; Mice/Mice/Mice/*genetics

• Source: Genetics [Genetics] 2020 Dec; Vol. 216 (4), pp. 905-930. Date of Electronic Publication: 2020 Oct 16.Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet

تفاصيل العنوان

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

• Authors : Finicle, Brendan T; Eckenstein, Kazumi H; Revenko, Alexey S

Subjects: Biochemistry and Cell Biology; Biological Sciences; Digestive Diseases

• Source: Nucleic Acids Research. 51(4)

تفاصيل العنوان

An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes.

• Authors : Le Brigand K; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097, 660, route des Lucioles, F-06560 Sophia Antipolis, France.; Russell R

Subjects: Databases, Nucleic Acid* ; Gene Expression Profiling* ; Oligonucleotide Array Sequence Analysis*

• Source: Nucleic acids research [Nucleic Acids Res] 2006 Jul 19; Vol. 34 (12), pp. e87. Date of Electronic Publication: 2006 Jul 19.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2-O-Methoxyethyl Antisense Oligonucleotide.

• Authors : Pirie, Elaine; Cauntay, Patrick; Fu, Wuxia

Subjects: GWAS; eQTL; inflammation

• Source: Nucleic Acid Therapeutics. 29(5)

تفاصيل العنوان

Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis.

• Authors : Kim, S; Graham, M; Lee, R

Subjects: Antisense oligonucleotide; Atherosclerosis; HB-EGF

• Source: Nutrition, Metabolism & Cardiovascular Diseases. 29(3)

تفاصيل العنوان

Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

• Authors : Langerak P; Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.; Nygren AO

Subjects: Oligonucleotide Probes* ; Recombination, Genetic*; Gene Targeting/Gene Targeting/Gene Targeting/*methods

• Source: Nucleic acids research [Nucleic Acids Res] 2005 Dec 09; Vol. 33 (22), pp. e188. Date of Electronic Publication: 2005 Dec 09.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

• Authors : Maimon, Roy; Chillon-Marinas, Carlos; Snethlage, Cedric E

Subjects: Biomedical and Clinical Sciences; Neurosciences; Neurodegenerative

• Source: Nature Neuroscience. 24(8)

تفاصيل العنوان