نتائج البحث

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

• Authors : Kempthorne, Liam; Vaizoglu, Deniz; Cammack, Alexander J

Subjects: C9orf72 Protein; Amyotrophic Lateral Sclerosis; Humans

• Source: Nature Communications , 16 , Article 459. (2025)

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CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis.

• Authors : Ko, Vivian; Ong, Kailee; Kwon, Deborah

Subjects: Amyotrophic lateral sclerosis; Casein kinase 1 delta; Casein kinase 1 epsilon

• Source: Acta Neuropathologica Communications. 12(1)

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Preservation of masseter muscle until the end stage in the SOD1G93A mouse model for ALS.

• Authors : Kawata, Sou; Seki, Soju; Nishiura, Akira

Subjects: Amyotrophic lateral sclerosis; Gastrocnemius muscle; Masseter muscles

• Source: Scientific Reports. 14(1)

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Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.

• Authors : An, Di¹ (AUTHOR); Han, Jingzhe² (AUTHOR); Fang, Pingping³ (AUTHOR)

• Source: CytoJournal. 9/30/2024, Vol. 21, p1-14. 14p.

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Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.

• Authors : Nowicka, Natalia; Zglejc-Waszak, Kamila; Juranek, Judyta

Subjects: AMYOTROPHIC lateral sclerosis; GLIAL fibrillary acidic protein; ADVANCED glycation end-products

• Source: PLoS ONE; 3/8/2024, Vol. 19 Issue 3, p1-16, 16p

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Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

• Authors : Mora, Santiago; Stuckert, Anna; von Huth Friis, Rasmus

Subjects: Animals; Amyotrophic Lateral Sclerosis/genetics; Interneurons/metabolism

• Source: Mora , S , Stuckert , A , von Huth Friis , R , Pietersz , K , Noes-Holt , G , Montañana-Rosell , R , Wang , H , Sørensen , A T , Selvan , R , Verhaagen , J & Allodi , I 2024 , ' Stabilization of V1

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ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons

• Authors : Zelina, Pavol; de Ruiter, Anna Aster; Kolsteeg, Christy ...

Subjects: Amyotrophic Lateral Sclerosis/genetics; Animals; DNA Damage

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ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes

• Authors : Vieira de Sá, Renata; Sudria-Lopez, Emma; Cañizares Luna, Marta ...

Subjects: Amyotrophic Lateral Sclerosis/genetics; Animals; Ataxin-2/genetics

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Frontotemporal Dementia-Like Disease Progression Elicited by Seeded Aggregation and Spread of FUS

• Authors : Vazquez-Sanchez, Sonia; Tilkin, Britt; Gasset-Rosa, Fatima

Subjects: animals; humans; mice

• Source: Department of Biochemistry and Molecular Biology Faculty Papers

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An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

• Authors : Bryson, JB; Kourgiantaki, A; Jiang, D

Subjects: ALS; Amyotrophic Lateral Sclerosis; cell transplant

• Source: eLife , 12 , Article RP88250. (2024)

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