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1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

• Authors : Béatrice Brion; Marc Le Borgne; Roderick E. Hubbard ...

Subjects: solvent-exposed; Magnetic Resonance Spectroscopy; Stereochemistry

• Source: Journal of Enzyme Inhibition and Medicinal ChemistryJournal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.1218-1225. ⟨10.1080/14756366.2019.1636235⟩

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Fragment‐based in silico design of SARS‐CoV‐2 main protease inhibitors

• Authors : Noorsaadah Abdul Rahman; Mamoona Nazir; Iskandar Abdullah

Subjects: Fragment-based drug discovery; Viral Protease Inhibitors; Protein Conformation

• Source: Chemistry and Biochemistry PublicationsChemical Biology & Drug Design

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Towards the De Novo Design of HIV-1 Protease Inhibitors Based on Natural Products

• Authors : Ana L. Chávez-Hernández; K. Eurídice Juárez-Mercado; Fernanda I. Saldívar-González

Subjects: artificial intelligence; de novo design; fragment-based drug discovery

• Source: BiomoleculesBiomolecules, Vol 11, Iss 1805, p 1805 (2021)Biomolecules; Volume 11; Issue 12; Pages: 1805

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Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

• Authors : Sourav Roy; Blake R. Rushing; Brandon L. Garcia

Subjects: Models, Molecular; medicine.medical_treatment; Fragment-based lead discovery

• Source: MoleculesVolume 25Issue 17Molecules, Vol 25, Iss 4016, p 4016 (2020)

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Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA

• Authors : Troy E. Messick; Edward R. Zartler; Garry R. Smith

Subjects: Models, Molecular; Herpesvirus 4, Human; Magnetic Resonance Spectroscopy

• Source: MoleculesVolume 25Issue 7Molecules, Vol 25, Iss 1760, p 1760 (2020)

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Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases

• Authors : Juliana da Fonseca Rezende e Mello; Drielli Gomes Vital-Fujii; Gustavo Henrique Goulart Trossini

Subjects: 0301 basic medicine; DOENÇAS NEGLIGENCIADAS; Trypanosoma brucei brucei

• Source: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)Universidade de São Paulo (USP)instacron:USP

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Application of Fragment-Based Drug Discovery against DNA Gyrase B

• Authors : Alvin W. Hung; Weiguang Seetoh; Jeffrey Hill

Subjects: chemistry.chemical_classification; Drug discovery; Fragment-based lead discovery

• Source: ChemPlusChem. 80(8)

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Lead Discovery of Type II BRAF V600E Inhibitors Targeting the Structurally Validated DFG-Out Conformation Based upon Selected Fragments

• Authors : Qidong You; Qingwen Zhang; Xuejin Zhang

Subjects: Models, Molecular; Proto-Oncogene Proteins B-raf; 0301 basic medicine

• Source: Molecules, Vol 21, Iss 7, p 879 (2016)MoleculesMolecules; Volume 21; Issue 7; Pages: 879

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Fragment-based Drug Discovery: the Shape of Things to Come

• Authors : Martin J. Drysdale

Subjects: Chemistry; Drug discovery; Fragment-based lead discovery

• Source: Australian Journal of Chemistry. 66:1544

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Fragment Hit Discovery and Binding Site Characterization by Indirect Affinity Capillary Electrophoresis: Application to Factor XIIa

• Authors : Clara Davoine (11603835); Alissia Pardo (11603838); Lionel Pochet (2060437)

Subjects: Biophysics; Biochemistry; Medicine

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