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Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet.

• Authors : Wei, Xinyi¹ ; Lu, Yunxu¹; Hong, Shangyu¹

Subjects: *GLUCOSE metabolism; *REDUCING diets; *DIET therapy for diabetes

• Source: Nutrients. Dec2024, Vol. 16 Issue 23, p4028. 13p.

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Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.

• Authors : Zhao YY; Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China.; Zhang LJ

Subjects: Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/antagonists & inhibitors ; Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/metabolism ; Fibroblast Growth Factors*/Fibroblast Growth Factors*/Fibroblast Growth Factors*/biosynthesis

• Source: International journal of molecular sciences [Int J Mol Sci] 2022 May 14; Vol. 23 (10). Date of Electronic Publication: 2022 May 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese A y Mice.

• Authors : Makarova E; The Laboratory of Physiological Genetics, The Institute of Cytology and Genetics, 630090 Novosibirsk, Russia.; Kazantseva A

Subjects: Fatty Liver/Fatty Liver/Fatty Liver/*drug therapy ; Fibroblast Growth Factors/Fibroblast Growth Factors/Fibroblast Growth Factors/*pharmacology ; Insulin/Insulin/Insulin/*blood

• Source: Cells [Cells] 2021 Dec 07; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats.

• Authors : Moro J; UMR PNCA, AgroParisTech, INRAe, Université Paris-Saclay, 16 rue Claude Bernard, 75005, Paris, France.; Chaumontet C

Subjects: Diet, Protein-Restricted/Diet, Protein-Restricted/Diet, Protein-Restricted/*adverse effects ; Fibroblast Growth Factors/Fibroblast Growth Factors/Fibroblast Growth Factors/*metabolism ; Hypothalamus/Hypothalamus/Hypothalamus/*metabolism

• Source: Scientific reports [Sci Rep] 2021 Jun 14; Vol. 11 (1), pp. 12436. Date of Electronic Publication: 2021 Jun 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

• Authors : Abu-Odeh, Mohammad; Zhang, Yuan; Reilly, Shannon M

Subjects: Biochemistry and Cell Biology; Biological Sciences; Nutrition

• Source: Cell Reports. 35(13)

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Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet.

• Authors : Nonogaki K; Laboratory of Diabetes and Nutrition, Tohoku University New Industry Creation Hatcher Center, 6-6-11 Aramakiaza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579, Japan. .; Kaji T

Subjects: Diet, High-Fat/Diet, High-Fat/Diet, High-Fat/*adverse effects ; Fibroblast Growth Factors/Fibroblast Growth Factors/Fibroblast Growth Factors/*metabolism ; Hyperglycemia/Hyperglycemia/Hyperglycemia/*drug therapy

• Source: Scientific reports [Sci Rep] 2020 Sep 25; Vol. 10 (1), pp. 15784. Date of Electronic Publication: 2020 Sep 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis.

• Authors : Liu, Cong; Schönke, Milena; Spoorenberg, Borah

Subjects: fibroblast growth factor 21; immunology; inflammation

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Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH.

• Authors : Henkel J; Department of Nutritional Biochemistry, Institute of Nutritional Science, University of Potsdam, D-14558 Nuthetal, Germany.; Buchheim-Dieckow K

Subjects: Exercise Therapy*/Exercise Therapy*/Exercise Therapy*/adverse effects ; Oxidative Stress* ; Physical Conditioning, Animal*/Physical Conditioning, Animal*/Physical Conditioning, Animal*/adverse effects

• Source: Nutrients [Nutrients] 2019 Nov 08; Vol. 11 (11). Date of Electronic Publication: 2019 Nov 08.Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN:

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FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk

• Authors : Chaffin, Aki T; Larson, Karlton R; Huang, Kuei-Pin

Subjects: Biomedical and Clinical Sciences; Health Sciences; Nutrition

• Source: JCI Insight. 7(19)

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Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes.

• Authors : Cui, Xiaona^1,2 (AUTHOR); Feng, Jin^1,3,4,5 (AUTHOR); Wei, Tianjiao^1,2 (AUTHOR)

• Source: Diabetologia. Mar2023, Vol. 66 Issue 3, p535-550. 16p.

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