نتائج البحث

KMT2A Rearrangements in Leukemias: Molecular Aspects and Therapeutic Perspectives.

• Authors : Guarnera L; Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44114, USA.; Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.

Subjects: Myeloid-Lymphoid Leukemia Protein*/Myeloid-Lymphoid Leukemia Protein*/Myeloid-Lymphoid Leukemia Protein*/genetics ; Histone-Lysine N-Methyltransferase*/Histone-Lysine N-Methyltransferase*/Histone-Lysine N-Methyltransferase*/genetics ; Gene Rearrangement*

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 20; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

• Source: A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688, NSC# 102816) to Chemotherapy in Infants With Acute Lymphoblastic

تفاصيل العنوان

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation (AUGMENT-101)

• Source: A Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in Patients With Relapsed/Refractory Leukemias, Including Those Harboring an MLL/KMT2A

تفاصيل العنوان

Pinometostat With Standard Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and MLL Gene Rearrangement

• Source: A Phase 1b/2 Study of Pinometostat in Combination With Standard Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia With MLL

تفاصيل العنوان

Validation of immunoglobulin gene rearrangement detection by PCR using commercially available BIOMED-2 primers.

• Authors : McClure RF; Kaur P; Pagel E

Subjects: DNA Primers/DNA Primers/DNA Primers/*genetics ; Immunoglobulin Variable Region/Immunoglobulin Variable Region/Immunoglobulin Variable Region/*genetics ; Immunoglobulins/Immunoglobulins/Immunoglobulins/*genetics

• Source: Leukemia [Leukemia] 2006 Jan; Vol. 20 (1), pp. 176-9.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print Cited Medium: Print

تفاصيل العنوان

MLL AT-hook sequence is strongly conserved in infant acute leukemia with or without MLL gene rearrangement.

• Authors : Macrini CM; Pombo-de-Oliveira MS; Ford AM

Subjects: Conserved Sequence* ; Proto-Oncogenes* ; Transcription Factors*

• Source: Leukemia [Leukemia] 2003 Jul; Vol. 17 (7), pp. 1432-3.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print Cited Medium: Print

تفاصيل العنوان

Aberrant leukemia-associated immunophenotype as potential harbinger of lineage switch in KMT2A -rearranged leukemia: a case series.

• Authors : Yost CM; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Houston, TX, USA.

Subjects: Leukemia*/Leukemia*/Leukemia*/diagnosis ; Leukemia*/Leukemia*/Leukemia*/genetics ; Myeloid-Lymphoid Leukemia Protein*/Myeloid-Lymphoid Leukemia Protein*/Myeloid-Lymphoid Leukemia Protein*/genetics

• Source: Leukemia & lymphoma [Leuk Lymphoma] 2020 Dec; Vol. 61 (14), pp. 3515-3518. Date of Electronic Publication: 2020 Sep 02.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.

• Authors : Feng Z; Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.; Yao Y

Subjects: Gene Rearrangement*; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Histone Demethylases/Histone Demethylases/Histone Demethylases/*antagonists & inhibitors

• Source: Journal of hematology & oncology [J Hematol Oncol] 2016 Mar 12; Vol. 9, pp. 24. Date of Electronic Publication: 2016 Mar 12.Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722

تفاصيل العنوان

Co-occurrence of BCR-ABL1 rearrangement and CALR mutation in a single leukemic stem cell: evidence that BCR-ABL1 oncogenic addiction prevails over CALR signaling.

• Authors : Balducci E; INSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France.; Assistance Publique-Hôpitaux de Paris, Service D'Hématologie, Hôpital Paul Brousse, Villejuif, France.

Subjects: Fusion Proteins, bcr-abl*/Fusion Proteins, bcr-abl*/Fusion Proteins, bcr-abl*/genetics ; Oncogene Addiction*; Leukemia/Leukemia/Leukemia/*genetics

• Source: Leukemia & lymphoma [Leuk Lymphoma] 2020 Jan; Vol. 61 (1), pp. 209-212. Date of Electronic Publication: 2019 Aug 29.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.

• Authors : Brzezinka K; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.; Nevedomskaya E

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Histone-Lysine N-Methyltransferase/Histone-Lysine N-Methyltransferase/Histone-Lysine N-Methyltransferase/*genetics

• Source: Journal of hematology & oncology [J Hematol Oncol] 2019 Jun 28; Vol. 12 (1), pp. 66. Date of Electronic Publication: 2019 Jun 28.Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722

تفاصيل العنوان