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Academic Journal

Alpha- to Beta-Cell Transdifferentiation in Neonatal Compared with Adult Mouse Pancreas in Response to a Modest Reduction in Beta-Cells Using Streptozotocin.

Authors : Hahm J; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada.; Lawson Health Research Institute, St. Joseph's Health Care, London, ON N6A 4V2, Canada.

Subjects: Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/metabolism ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/cytology ; Cell Transdifferentiation*

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 17; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Bariatric surgery induces pancreatic cell transdifferentiation as indicated by single-cell transcriptomics in Zucker diabetic rats.

Authors : Liang Y; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.; Fudan Zhangjiang Institute, Fudan University, Shanghai, China.

Subjects: Rats, Zucker* ; Cell Transdifferentiation*/Cell Transdifferentiation*/Cell Transdifferentiation*/genetics ; Bariatric Surgery*/Bariatric Surgery*/Bariatric Surgery*/methods

Source: Journal of diabetes [J Diabetes] 2024 Aug; Vol. 16 (8), pp. e13521. Date of Electronic Publication: 2023 Dec 27.Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Taurine rescues pancreatic β-cell stress by stimulating α-cell transdifferentiation.

Authors : Sarnobat D; School of Biomedical Sciences, Ulster University, Coleraine, UK.; Moffett RC

Subjects: Islets of Langerhans*/Islets of Langerhans*/Islets of Langerhans*/metabolism ; Insulin-Secreting Cells*; Humans

Source: BioFactors (Oxford, England) [Biofactors] 2023 May-Jun; Vol. 49 (3), pp. 646-662. Date of Electronic Publication: 2023 Jan 30.Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.

Authors : Lee K; Garvan Institute of Medical Research, St Vincent's Clinical School, UNSW Sydney, Darlinghurst, NSW, Australia.; Chan JY

Subjects: Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/genetics ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/metabolism ; Insulin Resistance*/Insulin Resistance*/Insulin Resistance*/genetics

Source: Diabetologia [Diabetologia] 2022 Jun; Vol. 65 (6), pp. 984-996. Date of Electronic Publication: 2022 Mar 22.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Repressing miR-23a promotes the transdifferentiation of pancreatic α cells to β cells via negatively regulating the expression of SDF-1α.

Authors : Lang H; Department of General Medicine, Chengdu Second People's Hospital, Chengdu, Sichuan Province, China.; Lin N

Subjects: Glucagon-Secreting Cells*/Glucagon-Secreting Cells*/Glucagon-Secreting Cells*/metabolism ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/metabolism ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics

Source: PloS one [PLoS One] 2024 Mar 22; Vol. 19 (3), pp. e0299821. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment.

Authors : Mahoney ALG; School of Life Sciences, University of Technology Sydney, Sydney 2007, Australia.; Nassif NT

Subjects: Cell Transdifferentiation*/Cell Transdifferentiation*/Cell Transdifferentiation*/genetics ; Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/genetics ; Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/therapy

Source: Cells [Cells] 2022 Jul 08; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects.

Authors : Fujita Y; Departments of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2-B5 Yamadaoka, Suita, 565-0871, Japan. .; Community Medicine, Graduate School of Medicine, Osaka University, Suita, Japan. .

Subjects: Cell Transdifferentiation* ; Gene Expression Regulation*; Glucagon-Secreting Cells/Glucagon-Secreting Cells/Glucagon-Secreting Cells/*metabolism

Source: Scientific reports [Sci Rep] 2021 Sep 07; Vol. 11 (1), pp. 17796. Date of Electronic Publication: 2021 Sep 07.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation.

Authors : Lu J; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; Liu KC

Subjects: Cell Transdifferentiation* ; Regeneration*; Glucagon-Secreting Cells/Glucagon-Secreting Cells/Glucagon-Secreting Cells/*physiology

Source: The EMBO journal [EMBO J] 2016 Sep 15; Vol. 35 (18), pp. 2026-44. Date of Electronic Publication: 2016 Aug 11.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1.

Authors : Zhang Z; Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.; Hu Y

Subjects: Cell Transdifferentiation/Cell Transdifferentiation/Cell Transdifferentiation/*drug effects ; Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/*metabolism ; Glucagon-Like Peptide 1/Glucagon-Like Peptide 1/Glucagon-Like Peptide 1/*pharmacology

Source: Journal of diabetes research [J Diabetes Res] 2019 Mar 13; Vol. 2019, pp. 2583047. Date of Electronic Publication: 2019 Mar 13 (Print Publication: 2019).Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Dysregulated insulin secretion is associated with pancreatic β-cell hyperplasia and direct acinar-β-cell trans-differentiation in partially eNOS-deficient mice.

Authors : Novelli M; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.; Masini M

Subjects: Insulin Resistance* ; Insulin-Secreting Cells*/Insulin-Secreting Cells*/Insulin-Secreting Cells*/metabolism; Animals

Source: Physiological reports [Physiol Rep] 2022 Aug; Vol. 10 (16), pp. e15425.Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM

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نتائج البحث

فلترة النتائج

Alpha- to Beta-Cell Transdifferentiation in Neonatal Compared with Adult Mouse Pancreas in Response to a Modest Reduction in Beta-Cells Using Streptozotocin.

Bariatric surgery induces pancreatic cell transdifferentiation as indicated by single-cell transcriptomics in Zucker diabetic rats.

Taurine rescues pancreatic β-cell stress by stimulating α-cell transdifferentiation.

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.

Repressing miR-23a promotes the transdifferentiation of pancreatic α cells to β cells via negatively regulating the expression of SDF-1α.

Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment.

Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects.

IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation.

A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1.

Dysregulated insulin secretion is associated with pancreatic β-cell hyperplasia and direct acinar-β-cell trans-differentiation in partially eNOS-deficient mice.

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