Source: The Journal of toxicological sciences [J Toxicol Sci] 2017; Vol. 42 (5), pp. 589-596.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids.

Authors : Takagi M; Graduate School of Biomedical and Health Sciences, Hiroshima University.; Sanoh S

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*cytology ; Phospholipids/Phospholipids/Phospholipids/*metabolism ; Spheroids, Cellular/Spheroids, Cellular/Spheroids, Cellular/*metabolism

Source: The Journal of toxicological sciences [J Toxicol Sci] 2016 Feb; Vol. 41 (1), pp. 155-64.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates.

Authors : Ferslew BC; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill.; Brouwer KL

Subjects: Models, Biological*; Biliary Tract/Biliary Tract/Biliary Tract/*metabolism ; Fluorobenzenes/Fluorobenzenes/Fluorobenzenes/*metabolism

Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2014 May; Vol. 139 (1), pp. 99-107. Date of Electronic Publication: 2014 Feb 22.Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

In vitro validation of drug-induced phospholipidosis.

Authors : Park S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Republic of Korea.; Choi YJ

Subjects: Drug-Related Side Effects and Adverse Reactions*; Hepatocytes/Hepatocytes/Hepatocytes/*drug effects ; Phospholipids/Phospholipids/Phospholipids/*metabolism

Source: The Journal of toxicological sciences [J Toxicol Sci] 2012; Vol. 37 (2), pp. 261-7.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.

Authors : Atienzar F; UCB Pharma SA, Non-Clinical Development, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium. ; Gerets H

Subjects: Gene Expression Profiling*; Biomarkers/Biomarkers/Biomarkers/*metabolism ; Hepatocytes/Hepatocytes/Hepatocytes/*metabolism

Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2007 Mar; Vol. 96 (1), pp. 101-14. Date of Electronic Publication: 2006 Dec 14.Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Print

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Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

Authors : Yasumi Yoshizane; Chise Tateno; Yuji Ishida

Subjects: 0301 basic medicine; Amiodarone; Endogeny

Source: The Journal of Toxicological Sciences. 42:589-596

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Glucosylceramide and Lysophosphatidylcholines as Potential Blood Biomarkers for Drug-Induced Hepatic Phospholipidosis

Authors : Masayo Urata; Hiroshi Yamada; Mayumi Murayama

Subjects: Male; Drug; Imipramine

Source: Toxicological Sciences. 141:377-386

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Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids

Authors : Yoko Ejiri; Yaichiro Kotake; Shigeru Ohta

Subjects: 0301 basic medicine; Metabolite; Phospholipid

Source: The Journal of toxicological sciences. 41(1)

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Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

Authors : Brian C. Ferslew; Kim L. R. Brouwer

Subjects: Anions; Male; Taurocholic Acid

Source: Toxicological sciences : an official journal of the Society of Toxicology. 139(1)

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In vitro validation of drug-induced phospholipidosis

Authors : Sora, Park; You-Jin, Choi; Byung-Hoon, Lee

Subjects: Fatty Liver; Drug-Related Side Effects and Adverse Reactions; Microscopy, Electron, Transmission

Source: The Journal of toxicological sciences. 37(2)

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نتائج البحث

فلترة النتائج

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.

Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids.

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates.

In vitro validation of drug-induced phospholipidosis.

Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

Glucosylceramide and Lysophosphatidylcholines as Potential Blood Biomarkers for Drug-Induced Hepatic Phospholipidosis

Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

In vitro validation of drug-induced phospholipidosis

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