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Academic Journal

Oncometabolite d-2HG alters T cell metabolism to impair CD8 + T cell function.

Authors : Notarangelo G; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Spinelli JB

Subjects: CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/metabolism ; Carcinogenesis*/Carcinogenesis*/Carcinogenesis*/genetics

Source: Science (New York, N.Y.) [Science] 2022 Sep 30; Vol. 377 (6614), pp. 1519-1529. Date of Electronic Publication: 2022 Sep 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

D-2-Hydroxyglutarate in Glioma Biology.

Authors : Chou FJ; Neuro-Oncology Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 1142E, Bethesda, MD 20892, USA.; Liu Y

Subjects: Glioma/Glioma/Glioma/*metabolism ; Glutarates/Glutarates/Glutarates/*metabolism ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*genetics

Source: Cells [Cells] 2021 Sep 07; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Metabolite-driven antitumor immunity.

Authors : Nathan JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.

Subjects: CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology ; Glutarates*/Glutarates*/Glutarates*/metabolism ; Glycolysis*/Glycolysis*/Glycolysis*/immunology

Source: Science (New York, N.Y.) [Science] 2022 Sep 30; Vol. 377 (6614), pp. 1488-1489. Date of Electronic Publication: 2022 Sep 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

Authors : Luna LA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, U.S.A.; Lesecq Z

Subjects: Mutation*; Glutarates/Glutarates/Glutarates/*metabolism ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*metabolism

Source: The Biochemical journal [Biochem J] 2020 Aug 28; Vol. 477 (16), pp. 2999-3018.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Academic Journal

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2.

Authors : Smolková K; Laboratory of Mitochondrial Physiology, No.75, Institute of Physiology of the Czech Academy of Sciences (IPHYS CAS), Vídeňská 1083, 14220, Prague, Czech Republic. .; Špačková J

Subjects: Glutarates/Glutarates/Glutarates/*metabolism ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*metabolism ; Mitochondria/Mitochondria/Mitochondria/*metabolism

Source: Scientific reports [Sci Rep] 2020 May 26; Vol. 10 (1), pp. 8677. Date of Electronic Publication: 2020 May 26.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.

Authors : Berger RS; Institute of Functional Genomics, University of Regensburg, Am BioPark 9, 93053, Regensburg, Germany.; Ellmann L

Subjects: Mutation*; Glutarates/Glutarates/Glutarates/*metabolism ; Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/Isocitrate Dehydrogenase/*genetics

Source: Scientific reports [Sci Rep] 2019 May 15; Vol. 9 (1), pp. 7436. Date of Electronic Publication: 2019 May 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.

Authors : Cuccarini V; Unit of Neuroradiology, Fondazione Irccs Istituto Neurologico Carlo Besta, Via Celoria 11, Milan, Italy.; Antelmi L

Subjects: Proton Magnetic Resonance Spectroscopy*/Proton Magnetic Resonance Spectroscopy*/Proton Magnetic Resonance Spectroscopy*/methods; Glioma/Glioma/Glioma/*drug therapy ; Glioma/Glioma/Glioma/*pathology

Source: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2020 Feb; Vol. 41 (2), pp. 347-355. Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Robust detection of oncometabolic aberrations by 1 H- 13 C heteronuclear single quantum correlation in intact biological specimens.

Authors : Barekatain Y; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Yan VC

Subjects: Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*analysis ; Glioblastoma/Glioblastoma/Glioblastoma/*metabolism ; Glutarates/Glutarates/Glutarates/*analysis

Source: Communications biology [Commun Biol] 2020 Jun 25; Vol. 3 (1), pp. 328. Date of Electronic Publication: 2020 Jun 25.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.

Authors : Walsby-Tickle J; Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.; Gannon J

Subjects: Chromatography, Ion Exchange* ; Mutation* ; Tandem Mass Spectrometry*

Source: Communications biology [Commun Biol] 2020 May 20; Vol. 3 (1), pp. 247. Date of Electronic Publication: 2020 May 20.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma.

Authors : Mohammad N; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Wong D

Subjects: Bone Neoplasms*/Bone Neoplasms*/Bone Neoplasms*/genetics ; Bone Neoplasms*/Bone Neoplasms*/Bone Neoplasms*/metabolism ; Chondrosarcoma*/Chondrosarcoma*/Chondrosarcoma*/genetics

Source: Histopathology [Histopathology] 2020 Apr; Vol. 76 (5), pp. 722-730. Date of Electronic Publication: 2020 Mar 10.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet

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نتائج البحث

فلترة النتائج

Oncometabolite d-2HG alters T cell metabolism to impair CD8 + T cell function.

D-2-Hydroxyglutarate in Glioma Biology.

Metabolite-driven antitumor immunity.

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2.

Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.

In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.

Robust detection of oncometabolic aberrations by 1 H- 13 C heteronuclear single quantum correlation in intact biological specimens.

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma.