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Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction

• Authors : Jae Hyun Kim; Kilsoo Jung; Chulho Lee

Subjects: Cell Line; Cell Survival / drug effects; Dose-Response Relationship

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Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors

• Authors : Areum Park; Jieon Hwang; Joo-Youn Lee

Subjects: Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology

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Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death

• Authors : Russo, Luigi; Mascanzoni, Fabiola; Farina, Biancamaria

Subjects: Animals; Apoptosis/drug effects; Apoptosis Inducing Factor/chemical synthesis

• Source: Russo , L , Mascanzoni , F , Farina , B , Dolga , A M , Monti , A , Caporale , A , Culmsee , C , Fattorusso , R , Ruvo , M & Doti , N 2021 , ' Design, Optimization, and Structural Characterization of

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Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons.

• Authors : Schinke, Christian; Fernandez Vallone, Valeria; Endres, Matthias

Subjects: info:eu-repo/classification/ddc/570; Antineoplastic Agents: toxicity; Axons: drug effectsDE

• Source: Neurobiology of disease 155, 105391 (2021). doi:10.1016/j.nbd.2021.105391

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Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons

• Authors : Sujin Hyung; Sun�륦young Im; Bo Yoon Lee

Subjects: Animals; Axons/drug effects; Axons/pathology

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Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition

• Authors : Chen, Mengqian; Li, Jing; Liang, Jiaxin

Subjects: CDK19; CDK8; STAT1 serine phosphorylation

• Source: Faculty Publications

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Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

• Authors : Mohammad-Beigi, Hossein; Aliakbari, Farhang; Sahin, Cagla

Subjects: synuclein (-synuclein); ADHERENCE; AGGREGATION

• Source: Mohammad-Beigi , H , Aliakbari , F , Sahin , C , Lomax , C , Tawfike , A , P. Schafer , N , Amiri-Nowdijeh , A , Eskandari , H , Møller , I M , Hosseini-Mazinani , M , Christiansen , G , Ward , J L ,

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Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells

• Authors : Jiménez, Rafael; Pequerul, Raquel; Amor Minguez, Adrián

Subjects: Aldehyde dehydrogenase; Cancer; Cancer stem cell

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Cholesterol modification of an anticancer drug for efficient incorporation into a supramolecular hydrogel system

• Authors : Bakker, Maarten H.; Grillaud, Maxime; Wu, Dan Jing

Subjects: Cholesterol; Controlled release; Drug delivery

• Source: Bakker , M H , Grillaud , M , Wu , D J , Fransen , P P K H , de Hingh , I H & Dankers , P Y W 2018 , ' Cholesterol modification of an anticancer drug for efficient

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Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice

• Authors : Vasou, Andri; Paulus, Christina; Narloch, Janina

Subjects: Antivirals; High-throughput screening (HTS); Human cytomegalovirus (CMV)

• Source: Vasou , A , Paulus , C , Narloch , J , Gage , Z O , Rameix-Welti , M A , Eléouët , J F , Nevels , M , Randall , R E & Adamson , C S 2018 , ' Modular cell-based

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