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Academic Journal

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer.

  • Authors : Esquer H; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; The Center for Drug Discovery, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/drug therapy ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/metabolism

  • Source: Cells [Cells] 2025 Feb 20; Vol. 14 (5). Date of Electronic Publication: 2025 Feb 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma.

  • Authors : Yu Z; Department of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.; Zhong L

Subjects: 5-Methylcytosine*/5-Methylcytosine*/5-Methylcytosine*/analogs & derivatives ; 5-Methylcytosine*/5-Methylcytosine*/5-Methylcytosine*/metabolism ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/genetics

  • Source: Clinical epigenetics [Clin Epigenetics] 2025 Jan 21; Vol. 17 (1), pp. 10. Date of Electronic Publication: 2025 Jan 21.Publisher: Biomed Central Country of Publication: Germany NLM ID: 101516977 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-7083

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Academic Journal

Rules of engagement for condensins and cohesins guide mitotic chromosome formation.

  • Authors : Samejima K; Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.; Gibcus JH

Subjects: Mitosis* ; Adenosine Triphosphatases*/Adenosine Triphosphatases*/Adenosine Triphosphatases*/metabolism ; Adenosine Triphosphatases*/Adenosine Triphosphatases*/Adenosine Triphosphatases*/chemistry

  • Source: Science (New York, N.Y.) [Science] 2025 Apr 11; Vol. 388 (6743), pp. eadq1709. Date of Electronic Publication: 2025 Apr 11.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1.

  • Authors : Nakata Y; Department of Systems Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8670, Japan. .; Nagasawa S

Subjects: Cell Cycle Checkpoints* ; DNA Damage* ; DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/metabolism

  • Source: Scientific reports [Sci Rep] 2024 Aug 03; Vol. 14 (1), pp. 17987. Date of Electronic Publication: 2024 Aug 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The YAP/TEAD4 transcriptional complex in intestinal macrophages promotes M2 polarization and alleviates DSS-induced colitis via the regulation of C/EBPβ.

  • Authors : Wang S; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Center of Digestive Disease, Central South University, Changsha, 410011, Hunan, China.

Subjects: Macrophages*/Macrophages*/Macrophages*/metabolism ; Transcription Factors*/Transcription Factors*/Transcription Factors*/metabolism ; Transcription Factors*/Transcription Factors*/Transcription Factors*/genetics

  • Source: Scientific reports [Sci Rep] 2025 Apr 06; Vol. 15 (1), pp. 11796. Date of Electronic Publication: 2025 Apr 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Interference with CHD1L inhibits the malignant progression and enhances cisplatin sensitivity of ovarian cancer cells by binding PLK1.

  • Authors : Qiao K; Department of Cancer Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, 250014, China. .; Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, 238 Jingshi Dong Lu, Lixia District, Jinan, Shandong, China. .

Subjects: Cisplatin*/Cisplatin*/Cisplatin*/pharmacology ; Cisplatin*/Cisplatin*/Cisplatin*/therapeutic use ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/pathology

  • Source: Journal of ovarian research [J Ovarian Res] 2025 Feb 24; Vol. 18 (1), pp. 38. Date of Electronic Publication: 2025 Feb 24.Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215

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Academic Journal

Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells.

  • Authors : Choi EH; Department of Biotechnology, Korea National University of Transportation, Chungbuk, 27909, Republic of Korea. .; Kim KP

Subjects: Chromosomal Proteins, Non-Histone*/Chromosomal Proteins, Non-Histone*/Chromosomal Proteins, Non-Histone*/metabolism ; Chromosomal Proteins, Non-Histone*/Chromosomal Proteins, Non-Histone*/Chromosomal Proteins, Non-Histone*/genetics ; Cell Cycle Proteins*/Cell Cycle Proteins*/Cell Cycle Proteins*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Mar 22; Vol. 15 (1), pp. 9918. Date of Electronic Publication: 2025 Mar 22.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

CDCA3-MYC positive feedback loop promotes bladder cancer progression via ENO1-mediated glycolysis.

  • Authors : Shen D; Department of Urology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. .; Yu X

Subjects: Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/pathology ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/genetics ; Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/Urinary Bladder Neoplasms*/metabolism

  • Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Feb 20; Vol. 44 (1), pp. 63. Date of Electronic Publication: 2025 Feb 20.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

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Academic Journal

Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome.

  • Authors : Zhao K; State Key Laboratory of Virology and Biosafety and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, China.; Wang J

Subjects: MRE11 Homologue Protein*/MRE11 Homologue Protein*/MRE11 Homologue Protein*/metabolism ; MRE11 Homologue Protein*/MRE11 Homologue Protein*/MRE11 Homologue Protein*/genetics ; Hepatitis B virus*/Hepatitis B virus*/Hepatitis B virus*/genetics

  • Source: PLoS pathogens [PLoS Pathog] 2025 Jan 03; Vol. 21 (1), pp. e1012824. Date of Electronic Publication: 2025 Jan 03 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

SMC translocation is unaffected by an excess of nucleoid associated proteins in vivo.

  • Authors : Ren Z; Department of Biology, Indiana University, 1001 E 3rd Street, Bloomington, IN 47405, USA.; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Subjects: Bacillus subtilis*/Bacillus subtilis*/Bacillus subtilis*/metabolism ; Bacillus subtilis*/Bacillus subtilis*/Bacillus subtilis*/genetics ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Jan 19; Vol. 15 (1), pp. 2447. Date of Electronic Publication: 2025 Jan 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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