نتائج البحث

Site-specific acetylation of polynucleotide kinase 3′-phosphatase regulates its distinct role in DNA repair pathways

• Authors : Islam, Azharul; Chakraborty, Anirban; Sarker, Altaf H

Subjects: Biochemistry and Cell Biology; Biological Sciences; Genetics

• Source: Nucleic Acids Research. 52(5)

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The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks.

• Authors : Dobson CJ; Biomedical Sciences Unit, Department of Biological Sciences, Lancaster University, Lancaster, LA1 4YQ, UK.; Allinson SL

Subjects: DNA Damage* ; DNA Repair*; Phosphoric Monoester Hydrolases/Phosphoric Monoester Hydrolases/Phosphoric Monoester Hydrolases/*metabolism

• Source: Nucleic acids research [Nucleic Acids Res] 2006 Apr 28; Vol. 34 (8), pp. 2230-7. Date of Electronic Publication: 2006 Apr 28 (Print Publication: 2006).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Electronic-Print Cited Medium: Internet ISSN:

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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

• Authors : Koch CA; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Agyei R

Subjects: DNA Damage* ; DNA Repair*; DNA/DNA/DNA/*metabolism

• Source: The EMBO journal [EMBO J] 2004 Oct 01; Vol. 23 (19), pp. 3874-85. Date of Electronic Publication: 2004 Sep 23.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining.

• Authors : Chappell C; Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.; Hanakahi LA

Subjects: Antigens, Nuclear* ; DNA Damage* ; DNA Helicases*

• Source: The EMBO journal [EMBO J] 2002 Jun 03; Vol. 21 (11), pp. 2827-32.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print Cited Medium: Print ISSN: 0261-4189 (Print)

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Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage

• Authors : Sams M. A. Sadat; Melinda Wuest; Igor M. Paiva

Subjects: DNA repair; DNA damage; PNKP

• Source: Frontiers in Oncology, Vol 11 (2021)

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The Interaction between Polynucleotide Kinase Phosphatase and the DNA Repair Protein XRCC1 Is Critical for Repair of DNA Alkylation Damage and Stable Association at DNA Damage Sites*

• Authors : Della-Maria, Julie; Hegde, Muralidhar L; McNeill, Daniel R

Subjects: Biochemistry and Cell Biology; Biological Sciences; Genetics

• Source: Journal of Biological Chemistry. 287(46)

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Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

• Authors : Sanchez, Arancha¹; Gadaleta, Mariana C.¹; Limbo, Oliver¹

• Source: PLoS Genetics. 9/18/2017, Vol. 13 Issue 9, p1-20. 20p.

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Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

• Authors : Mariana C. Gadaleta; Arancha Sánchez; Paul Russell

Subjects: 0301 basic medicine; Cancer Research; DNA Repair

• Source: PLoS Genetics, Vol 13, Iss 9, p e1007013 (2017)PLoS Genetics

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The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks

• Authors : Caroline J. Dobson; Sarah L. Allinson

Subjects: Binding Sites; Polynucleotide 5'-Hydroxyl-Kinase; DNA Repair

• Source: Nucleic Acids Research

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DataSheet_1_Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage.pdf

• Authors : Sams M. A. Sadat (11870921); Melinda Wuest (1653253); Igor M. Paiva (11870924)

Subjects: Cancer; Cancer Cell Biology; Cancer Diagnosis

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