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  • 1-10 ل  1,414 نتائج ل ""CHECKPOINT kinase 1""

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Subject : dna damage
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Academic Journal

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.

  • Authors : Fernandez A; Program in Solid Tumors, CIMA, Cancer Center Clinica Universidad de Navarra (CCUN), University of Navarra, Avenida de Pio XII, 55, 31008 Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, 31008 Pamplona, Spain.

Subjects: DNA Damage* ; Checkpoint Kinase 2*/Checkpoint Kinase 2*/Checkpoint Kinase 2*/metabolism ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism

  • Source: Cells [Cells] 2025 May 20; Vol. 14 (10). Date of Electronic Publication: 2025 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Checkpoint kinases regulate the circadian clock after DNA damage by influencing chromatin dynamics.

  • Authors : Yang Y; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China.

Subjects: DNA Damage* ; Neurospora crassa*/Neurospora crassa*/Neurospora crassa*/genetics ; Neurospora crassa*/Neurospora crassa*/Neurospora crassa*/metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2025 Feb 27; Vol. 53 (5).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint Pathway.

  • Authors : Lim HE; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Republic of Korea.; Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea.

Subjects: Cell Cycle Proteins*/Cell Cycle Proteins*/Cell Cycle Proteins*/metabolism ; Cell Cycle Proteins*/Cell Cycle Proteins*/Cell Cycle Proteins*/genetics ; DNA Damage*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 05; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Checkpoint Kinase 1 Is a Key Signal Transducer of DNA Damage in the Early Mammalian Cleavage Embryo.

  • Authors : Baran V; Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Šoltésovej 4, 040 00 Košice, Slovakia.; Mayer A

Subjects: Checkpoint Kinase 1*/Checkpoint Kinase 1*/Checkpoint Kinase 1*/metabolism ; DNA Damage* ; Embryonic Development*/Embryonic Development*/Embryonic Development*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 05; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

  • Authors : Naeem W; Institute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.; Nawab F

Subjects: DNA Repair*/DNA Repair*/DNA Repair*/genetics ; Mutation* ; Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/genetics

  • Source: Scientific reports [Sci Rep] 2025 Mar 06; Vol. 15 (1), pp. 7896. Date of Electronic Publication: 2025 Mar 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.

  • Authors : Höfer S; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; Frasch L

Subjects: Deoxycytidine*/Deoxycytidine*/Deoxycytidine*/analogs & derivatives ; Deoxycytidine*/Deoxycytidine*/Deoxycytidine*/pharmacology ; DNA Damage*/DNA Damage*/DNA Damage*/drug effects

  • Source: Molecular systems biology [Mol Syst Biol] 2025 Mar; Vol. 21 (3), pp. 231-253. Date of Electronic Publication: 2025 Jan 21.Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.

  • Authors : Murray CE; Graduate School of Biomedical Sciences and Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.; Kornepati AVR

Subjects: B7-H1 Antigen*/B7-H1 Antigen*/B7-H1 Antigen*/metabolism ; B7-H1 Antigen*/B7-H1 Antigen*/B7-H1 Antigen*/genetics ; Checkpoint Kinase 2*/Checkpoint Kinase 2*/Checkpoint Kinase 2*/metabolism

  • Source: Molecular cancer [Mol Cancer] 2024 Oct 30; Vol. 23 (1), pp. 242. Date of Electronic Publication: 2024 Oct 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer.

  • Authors : Nieto-Jimenez C; Translational Research Unit and CIBERONC, Albacete University Hospital, 02002 Albacete, Spain.; Translational Oncology Laboratory, Centro Regional de Investigaciones Biomédicas (CRIB) and Nursery School, Campus de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, Spain.

Subjects: DNA Damage*; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*drug therapy ; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*enzymology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 27; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint.

  • Authors : Washif M; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.; Kawasumi R

Subjects: DNA Replication* ; Floxuridine*/Floxuridine*/Floxuridine*/pharmacology ; DNA Damage*

  • Source: PLoS genetics [PLoS Genet] 2024 Jul 02; Vol. 20 (7), pp. e1011341. Date of Electronic Publication: 2024 Jul 02 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets.

  • Authors : Khamidullina AI; Laboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.

Subjects: DNA Damage* ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 ل  1,414 نتائج ل ""CHECKPOINT kinase 1""