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Academic Journal

Characterization of HIV-1 Integrase Gene and Resistance Associated Mutations Prior to Roll out of Integrase Inhibitors by Kenyan National HIV-Treatment Program in Kenya.

Authors : Mabeya S; Department of Medical Microbiology, school of Biomedical Sciences, Jomo Kenyatta University of Agriculture & Technology, Nairobi, Kenya.; Nyamache A

Subjects: DNA, Viral/DNA, Viral/DNA, Viral/*genetics ; HIV Infections/HIV Infections/HIV Infections/*virology ; HIV Integrase/HIV Integrase/HIV Integrase/*genetics

Source: Ethiopian journal of health sciences [Ethiop J Health Sci] 2020 Jan; Vol. 30 (1), pp. 37-44.Publisher: Research and Publications Office of Jimma University Country of Publication: Ethiopia NLM ID: 101224773 Publication Model: Print Cited Medium:

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Academic Journal

Interaction of HIV-1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV-1 replication.

Authors : Yadav P; Department of Chemistry, University of Delhi, Delhi, 110007, India.; Sur S

Subjects: Host Microbial Interactions* ; Virus Replication*; DNA, Viral/DNA, Viral/DNA, Viral/*metabolism

Source: Retrovirology [Retrovirology] 2019 Apr 29; Vol. 16 (1), pp. 12. Date of Electronic Publication: 2019 Apr 29.Publisher: BioMed Central Country of Publication: England NLM ID: 101216893 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-4690

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Academic Journal

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.

Authors : Métifiot M; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA .; Johnson BC

Subjects: Catalytic Domain*; DNA, Viral/DNA, Viral/DNA, Viral/*metabolism ; Drug Resistance, Viral/Drug Resistance, Viral/Drug Resistance, Viral/*drug effects

Source: Nucleic acids research [Nucleic Acids Res] 2016 Aug 19; Vol. 44 (14), pp. 6896-906. Date of Electronic Publication: 2016 Jul 01.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.

Authors : Pandey KK; Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, St. Louis, MO, USA. .; Bera S

Subjects: Cryoelectron Microscopy* ; Single Molecule Imaging* ; Virus Integration*/Virus Integration*/Virus Integration*/drug effects

Source: Communications biology [Commun Biol] 2021 Mar 12; Vol. 4 (1), pp. 330. Date of Electronic Publication: 2021 Mar 12.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.

Authors : Winans S; Columbia University, Department of Biochemistry and Molecular Biophysics, New York, New York, United States of America.; Columbia University, Department of Microbiology and Immunology, New York, New York, United States of America.

Subjects: DNA, Viral/DNA, Viral/DNA, Viral/*physiology ; HIV Integrase/HIV Integrase/HIV Integrase/*genetics ; HIV-1/HIV-1/HIV-1/*genetics

Source: PLoS pathogens [PLoS Pathog] 2020 Dec 22; Vol. 16 (12), pp. e1009147. Date of Electronic Publication: 2020 Dec 22 (Print Publication: 2020).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration.

Authors : Thierry S; Munir S; Thierry E

Subjects: Virus Integration* ; Virus Replication*; DNA, Viral/DNA, Viral/DNA, Viral/*metabolism

Source: Retrovirology [Retrovirology] 2015 Mar 12; Vol. 12, pp. 24. Date of Electronic Publication: 2015 Mar 12.Publisher: BioMed Central Country of Publication: England NLM ID: 101216893 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-4690

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Academic Journal

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.

Authors : Balakrishnan M; Gilead Sciences Inc., Foster City, California, United States of America.; Yant SR

Subjects: DNA, Viral/DNA, Viral/DNA, Viral/*antagonists & inhibitors ; HIV Integrase/HIV Integrase/HIV Integrase/*genetics ; HIV Integrase Inhibitors/HIV Integrase Inhibitors/HIV Integrase Inhibitors/*pharmacology

Source: PloS one [PLoS One] 2013 Sep 09; Vol. 8 (9), pp. e74163. Date of Electronic Publication: 2013 Sep 09 (Print Publication: 2013).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Influence of the amino-terminal sequence on the structure and function of HIV integrase

Authors : Grant Eilers; Kushol Gupta; Audrey Allen

Subjects: 0301 basic medicine; Protein Folding; Integrases

Source: RetrovirologyRetrovirology, Vol 17, Iss 1, Pp 1-16 (2020)

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Academic Journal

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.

Authors : Carayon K; LBPA, CNRS, Ecole Normale Supérieure de Cachan, 61 av. du Président Wilson, 94235 Cachan, France.; Leh H

Subjects: DNA, Viral/DNA, Viral/DNA, Viral/*chemistry ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*chemistry ; HIV Integrase/HIV Integrase/HIV Integrase/*chemistry

Source: Nucleic acids research [Nucleic Acids Res] 2010 Jun; Vol. 38 (11), pp. 3692-708. Date of Electronic Publication: 2010 Feb 17.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Dialysis purification of integrase-DNA complexes provides high-resolution atomic force microscopy images: dimeric recombinant HIV-1 integrase binding and specific looping on DNA.

Authors : Tsuruyama T; Department of Anatomical, Forensic Medicine, and Pathological Studies, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto Prefecture, Japan. ; Nakai T

Subjects: Nucleic Acid Conformation* ; Protein Multimerization*; DNA, Viral/DNA, Viral/DNA, Viral/*chemistry

Source: PloS one [PLoS One] 2013; Vol. 8 (1), pp. e53572. Date of Electronic Publication: 2013 Jan 14.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet

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نتائج البحث

فلترة النتائج

Characterization of HIV-1 Integrase Gene and Resistance Associated Mutations Prior to Roll out of Integrase Inhibitors by Kenyan National HIV-Treatment Program in Kenya.

Interaction of HIV-1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV-1 replication.

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.

Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.

Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration.

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.

Influence of the amino-terminal sequence on the structure and function of HIV integrase

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.

Dialysis purification of integrase-DNA complexes provides high-resolution atomic force microscopy images: dimeric recombinant HIV-1 integrase binding and specific looping on DNA.

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