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Academic Journal

Effects of a single subanesthetic dose of esketamine on postoperative subthreshold depressive symptoms in patients undergoing unilateral modified radical mastectomy: a randomised, controlled, double-blind trial.

  • Authors : Wang H; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.; Te R

Subjects: Ketamine*/Ketamine*/Ketamine*/administration & dosage ; Ketamine*/Ketamine*/Ketamine*/therapeutic use ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/surgery

  • Source: BMC psychiatry [BMC Psychiatry] 2024 Apr 24; Vol. 24 (1), pp. 315. Date of Electronic Publication: 2024 Apr 24.Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X

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Academic Journal

BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model.

  • Authors : Ju L; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Yang J

Subjects: Antidepressive Agents*/Antidepressive Agents*/Antidepressive Agents*/pharmacology ; Brain-Derived Neurotrophic Factor*/Brain-Derived Neurotrophic Factor*/Brain-Derived Neurotrophic Factor*/metabolism ; C-Reactive Protein*/C-Reactive Protein*/C-Reactive Protein*/metabolism

  • Source: BMC psychiatry [BMC Psychiatry] 2022 Mar 15; Vol. 22 (1), pp. 182. Date of Electronic Publication: 2022 Mar 15.Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X

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Academic Journal

Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice.

  • Authors : Estrada-Reyes R; Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico.; Quero-Chávez DB

Subjects: Antidepressive Agents/Antidepressive Agents/Antidepressive Agents/*therapeutic use ; Depression/Depression/Depression/*drug therapy ; Ketamine/Ketamine/Ketamine/*therapeutic use

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 26; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway.

  • Authors : Ouyang X; Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Road, Luzhou, 646000, Sichuan Province, People's Republic of China.; Department of Anesthesiology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, People's Republic of China.

Subjects: Behavior, Animal* ; MAP Kinase Signaling System*/MAP Kinase Signaling System*/MAP Kinase Signaling System*/drug effects; Depression/Depression/Depression/*drug therapy

  • Source: Scientific reports [Sci Rep] 2021 Sep 13; Vol. 11 (1), pp. 18181. Date of Electronic Publication: 2021 Sep 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Rapid-acting and long-lasting antidepressant-like action of (R)-ketamine in Nrf2 knock-out mice: a role of TrkB signaling.

  • Authors : Qu Y; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Shan J

Subjects: Antidepressive Agents/Antidepressive Agents/Antidepressive Agents/*pharmacology ; Behavior, Animal/Behavior, Animal/Behavior, Animal/*drug effects ; Depression/Depression/Depression/*drug therapy

  • Source: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2021 Apr; Vol. 271 (3), pp. 439-446. Date of Electronic Publication: 2020 Nov 12.Publisher: Springer International Country of Publication: Germany NLM ID: 9103030 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Adverse Effects of Esketamine for the Treatment of Major Depression Disorder: Findings from Randomized Controlled Trials.

  • Authors : Yang S; Department of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.; Wang J

Subjects: Depression* ; Dizziness*; Humans

  • Source: The Psychiatric quarterly [Psychiatr Q] 2022 Mar; Vol. 93 (1), pp. 81-95. Date of Electronic Publication: 2021 Jan 07.Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0376465 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression.

  • Authors : Aleksandrova LR; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Subjects: Depression/Depression/Depression/*physiopathology ; Hippocampus/Hippocampus/Hippocampus/*physiopathology ; Ketamine/Ketamine/Ketamine/*analogs & derivatives

  • Source: Molecular brain [Mol Brain] 2020 Jun 16; Vol. 13 (1), pp. 92. Date of Electronic Publication: 2020 Jun 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606

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Academic Journal

Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression.

  • Authors : Yang Y; Anesthesia and Operation Center, The First Medical Center of Chinese PLA General Hospital, Medical school of Chinese PLA, No. 28 Fuxing Road, Beijing, 100853, China. .; Song Y

Subjects: Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*therapeutic use ; Antidepressive Agents/Antidepressive Agents/Antidepressive Agents/*therapeutic use ; Antioxidants/Antioxidants/Antioxidants/*therapeutic use

  • Source: Psychopharmacology [Psychopharmacology (Berl)] 2020 Jun; Vol. 237 (6), pp. 1657-1669. Date of Electronic Publication: 2020 Mar 03.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression.

  • Authors : Huang N; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.; Wang Y

Subjects: Depression/Depression/Depression/*drug therapy ; Depression/Depression/Depression/*metabolism ; Glycine/Glycine/Glycine/*metabolism

  • Source: Psychopharmacology [Psychopharmacology (Berl)] 2019 Dec; Vol. 236 (12), pp. 3513-3523. Date of Electronic Publication: 2019 Jul 18.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.

  • Authors : Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; Highland JN

Subjects: Anesthetics/Anesthetics/Anesthetics/*adverse effects ; Antidepressive Agents/Antidepressive Agents/Antidepressive Agents/*adverse effects ; Behavior, Animal/Behavior, Animal/Behavior, Animal/*drug effects

  • Source: British journal of pharmacology [Br J Pharmacol] 2019 Jul; Vol. 176 (14), pp. 2573-2592. Date of Electronic Publication: 2019 May 13.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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