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Subject : chemistry.chemical_compound فلترة بواسطة : موضوع

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Physiologically‐based pharmacokinetic modeling to predict CYP3A4‐mediated drug‐drug interactions of finerenone

Authors : Thomas Eissing; Thomas Wendl; Sebastian Frechen

Subjects: Drug; Physiologically based pharmacokinetic modelling; Efavirenz

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 199-211 (2022)

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Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics

Authors : Caroline Flora Samer; Camille Lenoir; Amine Niederer

Subjects: Physiologically based pharmacokinetic modelling; Midazolam; Metabolite

Source: CPT: Pharmacometrics & Systems PharmacologyCPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 30-43 (2022)

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Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet

Authors : Karen Rowland Yeo; Zoe Barter; Lisa von Moltke

Subjects: Male; Olanzapine; Physiologically based pharmacokinetic modelling

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1071-1080 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi–Physiologically Based Modeling Approaches

Authors : Devin Welty; Kefeng Sun

Subjects: Male; Physiologically based pharmacokinetic modelling; Metabolite

Source: Drug Metabolism and Disposition. 49:1025-1037

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Application of a dual mechanistic approach to support bilastine dose selection for older adults

Authors : Stephan Schmidt; Cristina Campo; Nerea Leal

Subjects: Adult; Male; Senescence

Source: CPT: Pharmacometrics & Systems PharmacologyAddi. Archivo Digital para la Docencia y la InvestigacióninstnameCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1006-1017

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Personalise vitamin D3 using physiologically based pharmacokinetic modelling

Authors : Tao You; Zhonghui Huang

Subjects: Vitamin; Physiologically based pharmacokinetic modelling; Time Factors

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 723-734 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Authors : Yu Li; Le Yang; Ling Dong

Subjects: Absorption (pharmacology); In situ intestinal perfusion; Physiologically based pharmacokinetic modelling

Source: Journal of Traditional Chinese Medical Sciences, Vol 8, Iss 3, Pp 238-247 (2021)

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Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

Authors : Lars M. Blank; Elke Schaeffeler; Annika R. P. Schneider

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: CPT: pharmacometrics & systems pharmacologyCPT: Pharmacometrics & Systems PharmacologyCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 782-793 (2021)

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Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

Authors : Matthew L. Rizk; Paul van den Berg; Maurice J. Ahsman

Subjects: Physiologically based pharmacokinetic modelling; Hepatitis C virus; Tutorials

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 658-670 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

Authors : Dermot F. McGinnity; Diansong Zhou; Shringi Sharma

Subjects: Male; Cancer Research; p glycoprotein

Source: Cancer Chemotherapy and Pharmacology

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