نتائج البحث

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.

• Authors : Zhang, Peixiang; Munier, Joseph; Wiese, Carrie

Subjects: Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors

• Source: Nature Communications. 15(1)

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TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.

• Authors : Zubia, Mario; Yong, Adeline; Holtz, Kristen

Subjects: P301S (PS19); TMEM16F; lipid scrambling

• Source: Proceedings of the National Academy of Sciences. 121(27)

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Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

• Authors : Jheng, Jia-Rong; DesJardin, Jacqueline; Chen, Yi-Yun

Subjects: beta 2-microglobulin; heart failure; hypertension

• Source: Arteriosclerosis, Thrombosis, and Vascular Biology. 44(7)

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White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models.

• Authors : Li, Liang; Feldman, Brian

Subjects: Adipose tissue; Cell biology; Endocrinology

• Source: The Journal of Clinical Investigation. 134(13)

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Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade

• Authors : Fortin, Bridget M; Pfeiffer, Shannon M; Insua-Rodríguez, Jacob

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Immunology

• Source: Nature Immunology. 25(7)

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Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis.

• Authors : Kavaliauskas, Povilas; Gu, Yiyou; Hasin, Naushaba

Subjects: Mucormycosis; Animals; Hypoxia-Inducible Factor 1

• Source: Nature Communications. 15(1)

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Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis

• Authors : Ng, Eunice Sze Yin; Hu, Jane; Jiang, Zhichun

Subjects: Biomedical and Clinical Sciences; Ophthalmology and Optometry; Rare Diseases

• Source: The FASEB Journal. 38(11)

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Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury.

• Authors : Lin, Hugo; Liang, Chan-Jung; Yang, Ming-Yu

Subjects: AKI; ATP synthase; Maleic acid

• Source: Apoptosis. 29(5-6)

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hTERT Peptide Fragment GV1001 Prevents the Development of Porphyromonas gingivalis-Induced Periodontal Disease and Systemic Disorders in ApoE-Deficient Mice.

• Authors : Chen, Wei; Kim, Sharon; Lee, Alicia

Subjects: Alzheimer disease; GV1001; Porphyromonas gingivalis

• Source: International Journal of Molecular Sciences. 25(11)

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Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells.

• Authors : Torres-Velarde, Julia; Allen, Kaitlin; Salvador-Pascual, Andrea

Subjects: 14-3-3ε; Cell death; GPx4

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A Double-Humanized Mouse Model for Studying Host Gut Microbiome-Immune Interactions in Gulf War Illness.

• Authors : Bose, Dipro; Saha, Punnag; Roy, Subhajit

Subjects: IL-6; NSG; TNF R-1

• Source: International Journal of Molecular Sciences. 25(11)

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In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin.

• Authors : Shao, Yanjiao; Liu, Canzhao; Liao, Hsin-Kai

Subjects: AAV; Cardiac function; Dilated cardiomyopathy

• Source: Genome Biology. 25(1)

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Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma.

• Authors : Zheng, Jianwei; Wang, Qianqian; Chen, Jianghe

Subjects: Osteosarcoma; Humans; Oxidative Phosphorylation

• Source: Cell Reports Medicine. 5(5)

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Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinsons disease.

• Authors : Fang, Ping; Yu, Lewis; Espey, Hannah

Subjects: Animals; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Parkinson Disease

• Source: Communications Biology. 7(1)

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Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.

• Authors : Parlakgül, Güneş; Pang, Song; Artico, Leonardo

Subjects: Fasting; Endoplasmic Reticulum; Animals

• Source: Nature Communications. 15(1)

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Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice.

• Authors : Keiser, Ashley; Dong, Tri; Kramár, Enikö

Subjects: Animals; Memory; Long-Term

• Source: Nature Communications. 15(1)

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Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimers disease mouse model.

• Authors : Henningfield, Caden; Soni, Neelakshi; Lee, Ryan

Subjects: Alzheimer’s disease; Amyloid; Dendrimers

• Source: Alzheimer’s Research & Therapy. 16(1)

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Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling.

• Authors : Fujita, Yu; Kadota, Tsukasa; Kaneko, Reika

Subjects: Acute Lung Injury; Humans; Extracellular Vesicles

• Source: Communications Biology. 7(1)

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Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

• Authors : Zheng, Weihao; Chang, I-Chang; Limberis, Jason

Subjects: Biochemistry and Cell Biology; Biomedical and Clinical Sciences; Biological Sciences

• Source: PLOS Pathogens. 20(5)

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Network-level encoding of local neurotransmitters in cortical astrocytes

• Authors : Cahill, Michelle K; Collard, Max; Tse, Vincent

Subjects: Biomedical and Clinical Sciences; Neurosciences; Brain Disorders

• Source: Nature. 629(8010)

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Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease

• Authors : Kang, You Jung; Hyeon, Seung Jae; McQuade, Amanda

Subjects: Biochemistry and Cell Biology; Biological Sciences; Acquired Cognitive Impairment

• Source: Advanced Science. 11(20)

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5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies.

• Authors : Wong, Jasmine; Weinfurtner, Kelley; Westover, Tamara

Subjects: Animals; Mice; Chromosome Deletion

• Source: Leukemia. 38(5)

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Repurposing mebendazole against triple-negative breast cancer CNS metastasis.

• Authors : Wang, Yuelong; Trinh, Thy; Solow-Cordero, David

Subjects: Breast cancer; Drug repurposing; Leptomeningeal disease

• Source: Journal of Neuro-Oncology. 168(1)

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De novo identification of CD4+ T cell epitopes.

• Authors : Zdinak, Paul; Trivedi, Nishtha; Grebinoski, Stephanie

Subjects: CD4-Positive T-Lymphocytes; Epitopes; T-Lymphocyte

• Source: Nature Methods. 21(5)

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D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease

• Authors : Hou, Ke; Pan, Hope; Shahpasand-Kroner, Hedieh

Subjects: Biochemistry and Cell Biology; Biological Sciences; Neurological

• Source: Science Advances. 10(18)

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A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury

• Authors : Yuan, Nina Y; Medders, Kathryn E; Sanchez, Ana B

Subjects: Medical Microbiology; Biomedical and Clinical Sciences; Immunology

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Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth.

• Authors : Muthukrishnan, Sree; Qi, Haocheng; Wang, David

Subjects: Humans; Glioma; Animals

• Source: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 22(7)

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Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms.

• Authors : Fernandez, Samantha; Ferguson, Lucas; Ingolia, Nicholas

Subjects: Protein Isoforms; Humans; Ribosomes

• Source: Life Science Alliance. 7(7)

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Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.

• Authors : Brindani, Nicoletta; Vuong, Linh; La Serra, Maria

Subjects: Animals; Antineoplastic Agents; Humans

• Source: Journal of medicinal and pharmaceutical chemistry. 67(12)

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Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1

• Authors : He, Ling; Ioannidis, Angeliki; Hoffman, Carter J

Subjects: Biological Sciences; Biomedical and Clinical Sciences; Oncology and Carcinogenesis

• Source: Cancer Research Communications. 4(6)

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PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice.

• Authors : Jung, Jinkyu; Schneider, Eric; Zhang, Wei

Subjects: Animals; Brain Neoplasms; Irinotecan

• Source: Scientific Reports. 14(1)

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Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation–contraction coupling in ventricular myocytes

• Authors : Rhana, Paula; Matsumoto, Collin; Fong, Zhihui

Subjects: Biological Sciences; Medical Physiology; Biomedical and Clinical Sciences

• Source: Proceedings of the National Academy of Sciences of the United States of America. 121(25)

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Ultrasensitive and multiplexed tracking of single cells using whole-body PET/CT.

• Authors : Nguyen, Hieu; Das, Neeladrisingha; Ricks, Matthew

Subjects: Positron Emission Tomography Computed Tomography; Animals; Single-Cell Analysis

• Source: Science Advances. 10(24)

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Nanomedicine Targeting Cuproplasia in Cancer: Labile Copper Sequestration Using Polydopamine Particles Blocks Tumor Growth In Vivo through Altering Metabolism and Redox Homeostasis.

• Authors : Bonet-Aleta, Javier; Encinas-Gimenez, Miguel; Oi, Miku

Subjects: bioimaging; cancer metabolism; copper

• Source: ACS Applied Materials and Interfaces. 16(23)

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IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy.

• Authors : Moyer, Cassandra; Lanier, Amanda; Qian, Jing

Subjects: Humans; Animals; Breast Neoplasms

• Source: Clinical Cancer Research. 30(11)

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The Development of Robust Antibodies to Sarcospan, a Dystrophin- and Integrin-Associated Protein, for Basic and Translational Research.

• Authors : Mokhonova, Ekaterina; Malik, Ravinder; Mamsa, Hafsa

Subjects: antibody; dystrophin; monoclonal

• Source: International Journal of Molecular Sciences. 25(11)

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Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy

• Authors : Rawson, Renee; Duong, Loan; Tkachenko, Eugene

Subjects: Medical Physiology; Biomedical and Clinical Sciences; Digestive Diseases

• Source: Mucosal Immunology. 17(3)

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SIMS: A deep-learning label transfer tool for single-cell RNA sequencing analysis

• Authors : Gonzalez-Ferrer, Jesus; Lehrer, Julian; O'Farrell, Ash

Subjects: Information and Computing Sciences; Biological Sciences; Machine Learning

• Source: Cell Genomics. 4(6)

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Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development

• Authors : Darbellay, Fabrice; Ramisch, Anna; Lopez-Delisle, Lucille

Subjects: Biological Sciences; Genetics; Congenital Structural Anomalies

• Source: Nature Communications. 15(1)

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The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains

• Authors : Jong Huat, Tee; Camats-Perna, Judith; Newcombe, Estella A

Subjects: Biochemistry and Cell Biology; Biological Sciences; Acquired Cognitive Impairment

• Source: Scientific Reports. 14(1)

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A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin

• Authors : Casselini, Carolina M; Parson, Henri K; Frizzi, Katie E

Subjects: Pharmacology and Pharmaceutical Sciences; Biomedical and Clinical Sciences; Neurosciences

• Source: Acta Neuropathologica. 147(1)

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Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice.

• Authors : Kato, Hiroyuki; Salgado, Mayra; Mendez, Daniel

Subjects: Humans; Animals; Islets of Langerhans Transplantation

• Source: Scientific Reports. 14(1)

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Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.

• Authors : Taenaka, Hiroki; Wick, Katherine; Sarma, Aartik

Subjects: Acute respiratory distress syndrome; Glucocorticoids; Pneumonia

• Source: Critical Care. 28(1)

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Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.

• Authors : Rose, Kevin; Jepson, Tyler; Shukla, Sankalp

Subjects: Alzheimer’s disease; ESCRT; STORM

• Source: Proceedings of the National Academy of Sciences. 121(22)

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Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors.

• Authors : Wang, Fengrong; Holmes, Michael; Hong, Hea

Subjects: Toxoplasma; Animals; Protozoan Proteins

• Source: Nature Communications. 15(1)

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Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

• Authors : Li, Jing; Hilimire, Thomas A; Yueying, Liu

Subjects: Biomedical and Clinical Sciences; Clinical Sciences; Oncology and Carcinogenesis

• Source: Journal of Clinical Investigation. 134(10)

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A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.

• Authors : Liang, Xiaoyi; Hoang, Kendy; Meyerink, Brandon

Subjects: Olig2; enhancer; gliogenesis

• Source: Proceedings of the National Academy of Sciences. 121(20)

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Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.

• Authors : Goyette, Marie-Anne; Stevens, Laura; DePinho, Carolyn

Subjects: HER2; brain metastasis; breast cancer

• Source: Proceedings of the National Academy of Sciences. 121(20)

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Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation.

• Authors : Berjis, Abdulla; Muthumani, Deeksha; Aguilar, Oscar

Subjects: Granzymes; Interleukin-15; Killer Cells

• Source: Nature Communications. 15(1)

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Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.

• Authors : Scranton, Kyle; John, Scott; Angelini, Marina

Subjects: Sodium-Calcium Exchanger; Animals; Myocytes

• Source: Nature Communications. 15(1)

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