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Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides

• Authors : Brian S. Mantilla; Jack S. White; William R. T. Mosedale

Subjects: Chemistry; QD1-999

• Source: Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)

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Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from Trypanosoma brucei

• Authors : Renan A. Gomes; Marcelo D. Polêto; Hugo Verli

Subjects: Chemistry; QD1-999

• Source: ACS Omega, Vol 10, Iss 4, Pp 3808-3819 (2024)

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

• Authors : Torrie, Leah S.¹; Zuccotto, Fabio¹; Robinson, David A.¹

Subjects: *TRYPANOSOMA brucei; *TRYPANOSOMA; *KINETOCHORE

• Source: PLoS ONE. 5/31/2019, Vol. 14 Issue 5, p1-16. 16p.

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In vitro anti-trypanosomal effects of selected phenolic acids on Trypanosoma brucei.

• Authors : Amisigo, Cynthia Mmalebna^1,2; Antwi, Christine Achiaa^1,2; Adjimani, Jonathan Partt^1,2

Subjects: *TRYPANOSOMIASIS treatment; *PHENOLIC acids; *TRYPANOSOMA brucei

• Source: PLoS ONE. 5/2/2019, Vol. 14 Issue 5, p1-17. 17p.

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

• Authors : Currier, Rachel B.¹; Ulrich, Kathrin^1,2; Leroux, Alejandro E.¹

• Source: PLoS Pathogens. 9/26/2019, Vol. 15 Issue 9, p1-36. 36p.

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The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

• Authors : Kelner, Anna¹; Tinti, Michele¹; Guther, Maria Lucia S.¹

Subjects: *MESSENGER RNA; *METHYLTRANSFERASES; *TRYPANOSOMA brucei

• Source: PLoS ONE. 7/24/2018, Vol. 13 Issue 7, p1-14. 14p.

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SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms.

• Authors : Iribarren, Paula Ana¹; Di Marzio, Lucía Ayelén¹; Berazategui, María Agustina¹

Subjects: *POST-translational modification; *SACCHAROMYCES cerevisiae; *TRYPANOSOMA brucei

• Source: PLoS ONE. 2/23/2018, Vol. 13 Issue 2, p1-20. 20p.

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Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.

• Authors : Steinmann, Michael E.¹; Schmidt, Remo S.^2,3; Macêdo, Juan P.⁴

Subjects: *ION transport (Biology); *TRYPANOSOMA brucei; *GENE expression

• Source: PLoS ONE. 12/15/2017, Vol. 12 Issue 12, p1-18. 18p.

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Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.

• Authors : Dewar, Caroline E.¹; MacGregor, Paula¹; Cooper, Sinclair¹

• Source: PLoS Pathogens. 7/18/2018, Vol. 14 Issue 7, p1-30. 30p.

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The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.

• Authors : Pirani, Karim¹; Zufferey, Rachel^1,2; Cheung-See-Kit, Melanie²

Subjects: *TRYPANOSOMA brucei; *ACYLTRANSFERASE genetics; *GLYCEROPHOSPHOLIPIDS

• Source: PLoS ONE. 7/17/2017, Vol. 12 Issue 7, p1-17. 17p.

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