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Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.

• Authors : Fernandez A; Program in Solid Tumors, CIMA, Cancer Center Clinica Universidad de Navarra (CCUN), University of Navarra, Avenida de Pio XII, 55, 31008 Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, 31008 Pamplona, Spain.

Subjects: DNA Damage* ; Checkpoint Kinase 2*/Checkpoint Kinase 2*/Checkpoint Kinase 2*/metabolism ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism

• Source: Cells [Cells] 2025 May 20; Vol. 14 (10). Date of Electronic Publication: 2025 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Checkpoint kinases regulate the circadian clock after DNA damage by influencing chromatin dynamics.

• Authors : Yang Y; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China.

Subjects: DNA Damage* ; Neurospora crassa*/Neurospora crassa*/Neurospora crassa*/genetics ; Neurospora crassa*/Neurospora crassa*/Neurospora crassa*/metabolism

• Source: Nucleic acids research [Nucleic Acids Res] 2025 Feb 27; Vol. 53 (5).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Correlation between Molecular Docking and the Stabilizing Interaction of HOMO-LUMO: Spirostans in CHK1 and CHK2, an In Silico Cancer Approach.

• Authors : Rosales-López A; Laboratorio de Elucidación y Síntesis en Química Orgánica, Instituto de Ciencias, BUAP, Puebla 72570, Mexico.; López-Castillo GN

Subjects: Molecular Docking Simulation* ; Checkpoint Kinase 1*/Checkpoint Kinase 1*/Checkpoint Kinase 1*/metabolism ; Checkpoint Kinase 1*/Checkpoint Kinase 1*/Checkpoint Kinase 1*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 06; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.

• Authors : Murray CE; Graduate School of Biomedical Sciences and Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.; Kornepati AVR

Subjects: B7-H1 Antigen*/B7-H1 Antigen*/B7-H1 Antigen*/metabolism ; B7-H1 Antigen*/B7-H1 Antigen*/B7-H1 Antigen*/genetics ; Checkpoint Kinase 2*/Checkpoint Kinase 2*/Checkpoint Kinase 2*/metabolism

• Source: Molecular cancer [Mol Cancer] 2024 Oct 30; Vol. 23 (1), pp. 242. Date of Electronic Publication: 2024 Oct 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke.

• Authors : Baixauli-Martín, Júlia^1,2 (AUTHOR); Burguete, Maria Consuelo^1,2 (AUTHOR); López-Morales, Mikahela A.^1,3 (AUTHOR)

Subjects: *Checkpoint kinase 2; *Checkpoint kinase 1; *Ischemic stroke

• Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p2364. 18p.

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Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63.

• Authors : Rinaldi VD; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.; Bloom JC

Subjects: DNA Damage* ; Meiosis*; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*metabolism

• Source: Genetics [Genetics] 2020 Jun; Vol. 215 (2), pp. 373-378. Date of Electronic Publication: 2020 Apr 09.Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet

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Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

• Authors : Naeem, Wafa¹ (AUTHOR); Nawab, Fouzia¹ (AUTHOR); Sarwar, Muhammad Tahir¹ (AUTHOR)

• Source: Scientific Reports. 3/6/2025, Vol. 15 Issue 1, p1-17. 17p.

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Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin.

• Authors : Liu B; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, 730000, China.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Biphenyl Compounds/Biphenyl Compounds/Biphenyl Compounds/*pharmacology ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*antagonists & inhibitors

• Source: Radiation and environmental biophysics [Radiat Environ Biophys] 2020 Nov; Vol. 59 (4), pp. 723-732. Date of Electronic Publication: 2020 Aug 28.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0415677 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Overexpression of CHK1 and CHK2 in pediatric patients of B -acute lymphoblastic leukemia.

• Authors : Heidari, Farshad¹; Faranoush, Mohammad²; Amini, Ali¹

• Source: Iranian Journal of Pediatric Hematology & Oncology. 2023, Vol. 13 Issue 4, p233-240. 7p.

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Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells.

• Authors : Liu, Huan^1,2 (AUTHOR) ; Zhang, Wenchao³ (AUTHOR); Jin, Lijie^2,4 (AUTHOR)

Subjects: *ATAXIA telangiectasia mutated protein; *DNA damage; *CHECKPOINT kinase 2

• Source: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 7, p6279. 21p.

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