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  • 1-10 ل  5,108 نتائج ل ""Structure-Activity Relationship""

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Subject : cell proliferation
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Academic Journal

Structure-Activity Relationship Studies on Highly Functionalized Pyrazole Hydrazones and Amides as Antiproliferative and Antioxidant Agents.

  • Authors : Lusardi M; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.; Signorello MG

Subjects: Pyrazoles*/Pyrazoles*/Pyrazoles*/chemistry ; Pyrazoles*/Pyrazoles*/Pyrazoles*/pharmacology ; Hydrazones*/Hydrazones*/Hydrazones*/chemistry

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 23; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Data-Driven Modelling of Substituted Pyrimidine and Uracil-Based Derivatives Validated with Newly Synthesized and Antiproliferative Evaluated Compounds.

  • Authors : Zukić S; Institute of Chemistry, University of Tartu, Ravila Street 14a, 50411 Tartu, Estonia.; Osmanović A

Subjects: Uracil*/Uracil*/Uracil*/chemistry ; Uracil*/Uracil*/Uracil*/analogs & derivatives ; Uracil*/Uracil*/Uracil*/pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 29; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

New Difunctional Derivatives of Betulin: Preparation, Characterization and Antiproliferative Potential.

  • Authors : Chrobak E; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.; Świtalska M

Subjects: Triterpenes*/Triterpenes*/Triterpenes*/pharmacology ; Triterpenes*/Triterpenes*/Triterpenes*/chemistry ; Triterpenes*/Triterpenes*/Triterpenes*/chemical synthesis

  • Source: Molecules (Basel, Switzerland) [Molecules] 2025 Jan 30; Vol. 30 (3). Date of Electronic Publication: 2025 Jan 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Two New Halimanes with a γ-Lactone from Croton argyratus.

  • Authors : Watanabe K; School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.; Saito Y

Subjects: Croton*/Croton*/Croton*/chemistry ; Diterpenes*/Diterpenes*/Diterpenes*/chemistry ; Diterpenes*/Diterpenes*/Diterpenes*/isolation & purification

  • Source: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2025; Vol. 73 (3), pp. 162-167.Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Design, Synthesis, and Antitumor Activity of Novel Eupatilin Derivatives Based on the Mannich Reaction.

  • Authors : Meng Y; Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China.; Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China.

Subjects: Drug Design* ; Flavonoids*/Flavonoids*/Flavonoids*/pharmacology ; Flavonoids*/Flavonoids*/Flavonoids*/chemistry

  • Source: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2025; Vol. 73 (2), pp. 112-120.Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and biological evaluation of ortho -phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases.

  • Authors : Hsu KC; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

Subjects: Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/pharmacology ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemical synthesis ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemistry

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2406025. Date of Electronic Publication: 2024 Sep 24.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Licochalcone A-Inspired Chalcones: Synthesis and Their Antiproliferative Potential in Prostate Cancer Cells.

  • Authors : Dorado RG; Department of Chemistry & Biochemistry, California State University, Fresno, CA 93740, USA.; Oceguera Nava EI

Subjects: Chalcones*/Chalcones*/Chalcones*/pharmacology ; Chalcones*/Chalcones*/Chalcones*/chemistry ; Chalcones*/Chalcones*/Chalcones*/chemical synthesis

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 20; Vol. 29 (24). Date of Electronic Publication: 2024 Dec 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents.

  • Authors : Rodriguez-Paniagua A; Departamento de Química Orgánica I, Facultad de Farmacia and Centro de Investigación Lascaray (Lascaray Research Center), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.; Tesauro C

Subjects: Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/pharmacology ; Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/chemical synthesis ; Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 19; Vol. 29 (24). Date of Electronic Publication: 2024 Dec 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents.

  • Authors : Li Y; Department of Chemistry, College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.; Yelv L

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2412865. Date of Electronic Publication: 2024 Oct 15.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Effects of thymoquinone and the curcumin analog EF-24 on the activity of the enzyme paraoxonase-1 in human glioblastoma cells U87MG.

  • Authors : Simsek E; Department of Medical Biology, Ankara Yildirim Beyazit University, Ankara, Turkey.; Sunguroglu A

Subjects: Aryldialkylphosphatase*/Aryldialkylphosphatase*/Aryldialkylphosphatase*/metabolism ; Aryldialkylphosphatase*/Aryldialkylphosphatase*/Aryldialkylphosphatase*/antagonists & inhibitors ; Glioblastoma*/Glioblastoma*/Glioblastoma*/drug therapy

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2339901. Date of Electronic Publication: 2024 Jun 12.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 ل  5,108 نتائج ل ""Structure-Activity Relationship""