نتائج البحث

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.

• Authors : Williams, Elsie M.¹; Little, Rory F.¹; Mowday, Alexandra M.²

Subjects: *CANCER treatment; *GENE therapy; *NITROREDUCTASES

• Source: Biochemical Journal. 10/15/2015, Vol. 471 Issue 2, p131-150. 23p.

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Oncosuppressive Suicide Gene Virotherapy “PVH1-yCD/5-FC” for Pancreatic Peritoneal Carcinomatosis Treatment: NFκB and Akt/PI3K Involvement.

• Authors : Réjiba, Soukaina¹; Bigand, Christelle¹; Parmentier, Celine¹

Subjects: *PERITONEAL cancer; *SUICIDAL behavior; *VIROTHERAPY

• Source: PLoS ONE. Aug2013, Vol. 8 Issue 8, p1-14. 14p.

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A triple suicide gene strategy that improves therapeutic effects and incorporates multimodality molecular imaging for monitoring gene functions.

• Authors : Xing, L.^1,2; Sun, X.^2,3; Deng, X.²

• Source: Cancer Gene Therapy. Jun2013, Vol. 20 Issue 6, p358-365. 8p. 2 Diagrams, 3 Graphs.

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Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer.

• Authors : Hlavaty, Juraj^1,2; Petznek, Helga¹; Holzmüller, Harry¹

Subjects: *CANCER cells; *CANCER treatment; *CELL lines

• Source: PLoS ONE. Jul2012, Vol. 7 Issue 7, p1-9. 9p.

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Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy.

• Authors : Dachs, Gabi U.¹ ; Hunt, Michelle A.¹ ; Syddall, Sophie²

Subjects: *DRUG therapy; *ANTINEOPLASTIC agents; *ALKYLATING agents

• Source: Molecules. Nov2009, Vol. 14 Issue 11, p4517-4545. 29p. 1 Diagram, 1 Chart.

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Implication of functional activity for determining therapeutic efficacy of suicide genes in vitro.

• Authors : Gopinath, P.¹; Sankar Ghosh, Siddhartha^1,2

Subjects: *ENZYMES; *GENE therapy; *ENZYME-linked immunosorbent assay

• Source: Biotechnology Letters. Nov2008, Vol. 30 Issue 11, p1913-1921. 9p. 2 Black and White Photographs, 2 Diagrams, 3 Graphs.

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Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury.

• Authors : Hedley, Douglas¹; Ogilvie, Lesley¹; Springer, Caroline¹

• Source: Nature Reviews Cancer. Nov2007, Vol. 7 Issue 11, p870-879. 10p. 1 Illustration, 3 Diagrams, 4 Charts, 1 Graph.

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Metabolism and Transport of Oxazaphosphorines and the Clinical Implications.

• Authors : Zhang, Jing¹ (AUTHOR); Tian, Quan¹ (AUTHOR); Yung Chan, Sui¹ (AUTHOR)

• Source: Drug Metabolism Reviews. Nov2005, Vol. 37 Issue 4, p611-703. 93p. 12 Diagrams.

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Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdΔ24.

• Authors : Oosterhoff, D.¹; Pinedo, H. M.¹; Witlox, M. A.¹

• Source: Gene Therapy. Jun2005, Vol. 12 Issue 12, p1011-1018. 8p.

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Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.

• Authors : Djeha, Hakim A¹; Todryk, Stephen M²; Pelech, Steven³

• Source: Cancer Gene Therapy. Jun2005, Vol. 12 Issue 6, p560-571. 12p.

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