Source: CPT: Pharmacometrics & Systems PharmacologyAddi. Archivo Digital para la Docencia y la InvestigacióninstnameCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1006-1017

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Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases

Authors : Christian Maass; Suruchi Bakshi; Cesar Pichardo-Almarza

Subjects: Drug; Physiologically based pharmacokinetic modelling; PBPK

Source: Journal of Pharmacokinetics and Pharmacodynamics

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Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment

Authors : Imam H. Shaik; Xiaohan Zhang; Ruichao Xu

Subjects: Physiologically based pharmacokinetic modelling; Administration, Oral; Models, Biological

Source: British Journal of Clinical Pharmacology. 88:587-599

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Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

Authors : Olena Anoshchenko; Mark A. Milad; Jashvant D. Unadkat

Subjects: Drug; Physiologically based pharmacokinetic modelling; Neonatal respiratory distress syndrome

Source: CPT: Pharmacometrics & Systems PharmacologyCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1057-1070 (2021)

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Prediction of maternal and fetal pharmacokinetics of indomethacin in pregnancy

Authors : Xiaoming Wang; Erik Rytting; Mansi Shah

Subjects: Pharmacology; Fetus; medicine.medical_specialty

Source: British Journal of Clinical Pharmacology. 88:271-281

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A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

Authors : Karen Rowland Yeo; Eva Gil Berglund; Ben G Small

Subjects: Clinical Trials as Topic; Physiologically based pharmacokinetic modelling; medicine.medical_specialty

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 967-972 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Authors : Amin Rostami-Hodjegan; Varinder Athwal; Adam S. Darwich

Subjects: Drug; Physiologically based pharmacokinetic modelling; Hepatology

Source: Alimentary Pharmacology & Therapeutics. 54:388-401

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Personalise vitamin D3 using physiologically based pharmacokinetic modelling

Authors : Tao You; Zhonghui Huang

Subjects: Vitamin; Physiologically based pharmacokinetic modelling; Time Factors

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 723-734 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Authors : Yu Li; Le Yang; Ling Dong

Subjects: Absorption (pharmacology); In situ intestinal perfusion; Physiologically based pharmacokinetic modelling

Source: Journal of Traditional Chinese Medical Sciences, Vol 8, Iss 3, Pp 238-247 (2021)

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Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

Authors : Lars M. Blank; Elke Schaeffeler; Annika R. P. Schneider

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: CPT: pharmacometrics & systems pharmacologyCPT: Pharmacometrics & Systems PharmacologyCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 782-793 (2021)

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Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants

Authors : Rachel G. Greenberg; Andrea N. Edginton; Michael Cohen-Wolkowiez

Subjects: Adult; 0301 basic medicine; Physiologically based pharmacokinetic modelling

Source: Clin Pharmacokinet

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Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population

Authors : Andrea N. Edginton; Sara Salerno; Michael Cohen-Wolkowiez

Subjects: Adult; Physiologically based pharmacokinetic modelling; Antifungal Agents

Source: Drug Metabolism and Disposition. 49:844-855

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Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

Authors : Matthew L. Rizk; Paul van den Berg; Maurice J. Ahsman

Subjects: Physiologically based pharmacokinetic modelling; Hepatitis C virus; Tutorials

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 658-670 (2021)CPT: Pharmacometrics & Systems Pharmacology

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A Model Template Approach for Rapid Evaluation and Application of Physiologically Based Pharmacokinetic Models for Use in Human Health Risk Assessments: A Case Study on Per- and Polyfluoroalkyl Substances

Authors : Paul M. Schlosser; Amanda S Bernstein; Dustin F. Kapraun

Subjects: Physiologically based pharmacokinetic modelling; Computer science; business.industry

Source: Toxicological Sciences. 182:215-228

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

Authors : Dermot F. McGinnity; Diansong Zhou; Shringi Sharma

Subjects: Male; Cancer Research; p glycoprotein

Source: Cancer Chemotherapy and Pharmacology

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PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

Authors : Alice Ke; Jayaprakasam Bolleddula; Chandra Prakash

Subjects: Physiologically based pharmacokinetic modelling; Pyridines; Midazolam

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 6, Pp 577-588 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan

Authors : Ying Hong; Frank LaCreta; Hitoshi Ishizuka

Subjects: Posaconazole; Physiologically based pharmacokinetic modelling; Indoles

Source: Clinical and Translational ScienceClinical and Translational Science, Vol 14, Iss 6, Pp 2220-2230 (2021)

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A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions

Authors : Juri Solodenko; Thomas Wendl; Jörg Lippert

Subjects: Physiologically based pharmacokinetic modelling; Open science; Traceability

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 6, Pp 633-644 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice

Authors : Weihsueh A. Chiu; Ivan Rusyn; Joseph A. Cichocki

Subjects: Male; Tetrachloroethylene; Physiologically based pharmacokinetic modelling

Source: Toxicol Sci

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Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects

Authors : Jie En Valerie Sia; Xueting Yao; Xiaobei Li

Subjects: Renal Excretion; Adult; Physiologically based pharmacokinetic modelling

Source: British Journal of Clinical Pharmacology

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Physiologically‐based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors

Authors : Edgar Schuck; Bojan Lalovic; Yukiko Miyajima

Subjects: Drug; Physiologically based pharmacokinetic modelling; CYP3A

Source: CPT: Pharmacometrics & Systems PharmacologyCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 455-466 (2021)

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Migalastat Tissue Distribution: Extrapolation From Mice to Humans Using Pharmacokinetic Modeling and Comparison With Agalsidase Beta Tissue Distribution in Mice

Authors : Anadina Garcia; Anthony Perry; Yi Lun

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: Clinical Pharmacology in Drug Development

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The shape of low-concentration dose–response functions for benzene: implications for human health risk assessment

Authors : Hans B. Ketelslegers; Louis Anthony Cox; R. Jeffrey Lewis

Subjects: China; Physiologically based pharmacokinetic modelling; Metabolite

Source: Critical Reviews in Toxicology. :1-24

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Food constituent– and herb–drug interactions in oncology: Influence of quantitative modelling on Drug labelling

Authors : Sibylle Neuhoff; Heeseung Jo; Venkatesh Pilla Reddy

Subjects: Oncology; medicine.medical_specialty; Physiologically based pharmacokinetic modelling

Source: British Journal of Clinical Pharmacology. 87:3988-4000

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Evaluation of Drug‐Drug Interaction Liability for Buprenorphine Extended‐Release Monthly Injection Administered by Subcutaneous Route

Authors : Malcolm A. Young; Yongzhen Liu; Céline M. Laffont

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: Clinical Pharmacology in Drug Development

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Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes

Authors : David W. Boulton; Weifeng Tang; Venkatesh Pilla Reddy

Subjects: Oncology; Male; Administration, Oral

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 108-118 (2021)CPT: Pharmacometrics & Systems Pharmacology

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PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

Authors : Hong Shen; Karelle Ménochet; Yueping Zhang

Subjects: Male; Coproporphyrins; Physiologically based pharmacokinetic modelling

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)Takita, H, Barnett, S, Zhang, Y, Ménochet, K, Shen, H, Ogungbenro, K & Galetin, A 2021, ' PBPK Model of

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Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

Authors : Vaishali Sahasrabudhe; Susanna Tse; Jian Lin

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 127-136 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Teicoplanin physiologically based pharmacokinetic modeling offers a quantitative assessment of a theoretical influence of serum albumin and renal function on its disposition

Authors : Chie Emoto; Trevor N. Johnson; Tsuyoshi Fukuda

Subjects: Male; Physiologically based pharmacokinetic modelling; Metabolic Clearance Rate

Source: European Journal of Clinical Pharmacology. 77:1157-1168

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Perspective on model‐informed drug development

Authors : Lawrence J. Lesko

Subjects: Physiologically based pharmacokinetic modelling; Process management; United States Food and Drug Administration

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1127-1129 (2021)CPT: Pharmacometrics & Systems Pharmacology

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Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair

Authors : Quintin Pope; Matthew D. Rand

Subjects: Adult; Physiologically based pharmacokinetic modelling; Physiology

Source: Toxicol Sci

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Application of physiologically based pharmacokinetic modeling to predict the pharmacokinetics of telavancin in obesity with renal impairment

Authors : Meng Ke; Wanhong Wu; Lingling Ye

Subjects: Adult; Male; Physiologically based pharmacokinetic modelling

Source: European Journal of Clinical Pharmacology

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Pharmacokinetics under the COVID‐19 storm

Authors : Eman El-Khateeb; Heeseung Jo; Shringi Sharma

Subjects: Drug; PBPK; Physiologically based pharmacokinetic modelling

Source: British Journal of Clinical PharmacologyReddy, V P, El-Khateeb, E, Jo, H, Giovino, N, Lythgoe, E, Sharma, S, Tang, W, Jamei, M & Rastomi-Hodjegan, A 2020, ' Pharmacokinetics under the COVID-19

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Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

Authors : Mayu Yanagi; Kaito Banju; Makiko Shimizu

Subjects: chemistry.chemical_compound; Physiologically based pharmacokinetic modelling; Pharmacokinetics

Source: The Journal of Toxicological Sciences. 46:391-399

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Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin

Authors : Yuan Chen; Jialin Mao; Christine M. Bowman

Subjects: Drug labeling; Physiologically based pharmacokinetic modelling; Drug disposition

Source: CPT: Pharmacometrics & Systems Pharmacology

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