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Interview with Dr William Slikker Jr., Ph.D., Former Director, National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), USA.

Authors : Dobran SA; RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.; Sociology Department, Babes-Bolyai University, Cluj-Napoca, Romania.

Subjects: United States Food and Drug Administration* ; Toxicology*; Humans

Source: Journal of medicine and life [J Med Life] 2022 Oct; Vol. 15 (10), pp. 1207-1208.Publisher:

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Academic Journal

Non-clinical combination toxicology studies: strategy, examples and future perspective.

Authors : Sacaan A; Drug Safety Research and Development, Pfizer, Inc., USA.; Hashida SN

Subjects: Drug Development*/Drug Development*/Drug Development*/trends; Toxicology/Toxicology/Toxicology/*methods ; Toxicology/Toxicology/Toxicology/*trends

Source: The Journal of toxicological sciences [J Toxicol Sci] 2020; Vol. 45 (7), pp. 365-371.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

A model-based approach to designing developmental toxicology experiments using sea urchin embryos.

Authors : Collins MD; Department of Environment Health Sciences and Molecular Toxicology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Cui EH

Subjects: Research Design*; Embryonic Development/Embryonic Development/Embryonic Development/*drug effects ; Toxicology/Toxicology/Toxicology/*methods

Source: Archives of toxicology [Arch Toxicol] 2022 Mar; Vol. 96 (3), pp. 919-932. Date of Electronic Publication: 2022 Jan 13.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Perspectives of future lung toxicology studies using human pluripotent stem cells.

Authors : Masui A; Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Nogi, Tochigi, Japan.

Subjects: Lung/Lung/Lung/*cytology ; Pluripotent Stem Cells/Pluripotent Stem Cells/Pluripotent Stem Cells/*cytology ; Toxicology/Toxicology/Toxicology/*methods

Source: Archives of toxicology [Arch Toxicol] 2022 Feb; Vol. 96 (2), pp. 389-402. Date of Electronic Publication: 2022 Jan 01.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations.

Authors : Singh PK; Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151 001, India.; Negi A

Subjects: Drug Design* ; Drug-Related Side Effects and Adverse Reactions* ; Pharmaceutical Preparations*/Pharmaceutical Preparations*/Pharmaceutical Preparations*/chemistry

Source: Archives of toxicology [Arch Toxicol] 2016 Aug; Vol. 90 (8), pp. 1785-802. Date of Electronic Publication: 2015 Sep 04.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Establishment of a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish.

Authors : Koseki N; Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.; Deguchi J

Subjects: Drug Discovery*; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*methods ; High-Throughput Screening Assays/High-Throughput Screening Assays/High-Throughput Screening Assays/*methods

Source: The Journal of toxicological sciences [J Toxicol Sci] 2014 Aug; Vol. 39 (4), pp. 579-600.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

General considerations in ocular toxicity risk assessment from the toxicologists' viewpoints.

Authors : Onodera H; Pharmaceutical & Medical Devices Agency.; Sasaki S

Subjects: Drug-Related Side Effects and Adverse Reactions* ; Risk Assessment* ; Toxicology*

Source: The Journal of toxicological sciences [J Toxicol Sci] 2015 Jun; Vol. 40 (3), pp. 295-307.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety.

Authors : Borgert CJ; Applied Pharmacology and Toxicology, Inc., Gainesville, FL, USA. .; Center for Environmental and Human Toxicology (CEHT), Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA. .

Subjects: Toxicokinetics*; Environmental Exposure/Environmental Exposure/Environmental Exposure/*legislation & jurisprudence ; Toxicology/Toxicology/Toxicology/*legislation & jurisprudence

Source: Archives of toxicology [Arch Toxicol] 2021 Dec; Vol. 95 (12), pp. 3651-3664. Date of Electronic Publication: 2021 Oct 08.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Editorial & Opinion

Introduction to special section on using pools to generate Good Laboratory Practice tox or other non-clinical material to accelerate development timelines.

Authors : DeMaria C; Cell Line Development, Global Biopharmaceutics Development, Sanofi, Framingham, MA, 01701.; Munro T

Subjects: Biotechnology/Biotechnology/Biotechnology/*trends ; CHO Cells/CHO Cells/CHO Cells/*metabolism ; Drug-Related Side Effects and Adverse Reactions/Drug-Related Side Effects and Adverse Reactions/Drug-Related Side Effects and Adverse Reactions/*metabolism

Source: Biotechnology progress [Biotechnol Prog] 2017 Nov; Vol. 33 (6), pp. 1435. Date of Electronic Publication: 2017 Nov 28.Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8506292 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science?

Authors : Horii I; Global Drug Safety Research & Development, Pfizer.

Subjects: Drug Discovery* ; Interdisciplinary Communication* ; Risk Management*

Source: The Journal of toxicological sciences [J Toxicol Sci] 2016; Vol. 41 (Special), pp. SP49-SP67.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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نتائج البحث

فلترة النتائج

Interview with Dr William Slikker Jr., Ph.D., Former Director, National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), USA.

Non-clinical combination toxicology studies: strategy, examples and future perspective.

A model-based approach to designing developmental toxicology experiments using sea urchin embryos.

Perspectives of future lung toxicology studies using human pluripotent stem cells.

Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations.

Establishment of a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish.

General considerations in ocular toxicity risk assessment from the toxicologists' viewpoints.

Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety.

Introduction to special section on using pools to generate Good Laboratory Practice tox or other non-clinical material to accelerate development timelines.

The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science?