Authors : Nakatani E; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.; Shizuoka General Hospital, Shizuoka, Japan.

Subjects: Biguanides*/Biguanides*/Biguanides*/adverse effects ; Biguanides*/Biguanides*/Biguanides*/economics ; Biguanides*/Biguanides*/Biguanides*/therapeutic use

Source: PloS one [PLoS One] 2024 Aug 09; Vol. 19 (8), pp. e0308734. Date of Electronic Publication: 2024 Aug 09 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent.

Authors : Vatté J; Département de Chimie, Faculté des Arts et des Sciences, Université de Montréal, 1375 Av. Thérèse Lavoie-Roux, Montréal, QC H2V 0B3, Canada.; Bourdeau V

Subjects: Mitochondria*/Mitochondria*/Mitochondria*/drug effects ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2024 Aug 09; Vol. 29 (16). Date of Electronic Publication: 2024 Aug 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.

Authors : Zhao J; Department of Burn Surgery, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, People's Republic of China.; Shi K

Subjects: Diabetic Foot*/Diabetic Foot*/Diabetic Foot*/therapy ; Diabetic Foot*/Diabetic Foot*/Diabetic Foot*/drug therapy ; Negative-Pressure Wound Therapy*/Negative-Pressure Wound Therapy*/Negative-Pressure Wound Therapy*/methods

Source: Scientific reports [Sci Rep] 2024 May 19; Vol. 14 (1), pp. 11423. Date of Electronic Publication: 2024 May 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.

Authors : Bridges HR; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.; Blaza JN

Subjects: Electron Transport Complex I*/Electron Transport Complex I*/Electron Transport Complex I*/antagonists & inhibitors ; Biguanides*/Biguanides*/Biguanides*/pharmacology; Animals

Source: Science (New York, N.Y.) [Science] 2023 Jan 27; Vol. 379 (6630), pp. 351-357. Date of Electronic Publication: 2023 Jan 26.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth.

Authors : Hébert A; Département de Chimie-Faculté des Arts et des Sciences, Université de Montréal, 2900 Edouard Montpetit, Succursale Centre-Ville, CP 6128, Montreal, QC, H3C3J7, Canada.; Parisotto M

Subjects: Biguanides/Biguanides/Biguanides/*pharmacology ; Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/*drug therapy ; Pancreatic Neoplasms/Pancreatic Neoplasms/Pancreatic Neoplasms/*drug therapy

Source: Scientific reports [Sci Rep] 2021 May 10; Vol. 11 (1), pp. 9854. Date of Electronic Publication: 2021 May 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System.

Authors : Mehrpour O; Data Science Institute, Southern Methodist University, Dallas, TX, USA. .; Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran. .

Subjects: Biguanides* ; Poisons*; Humans

Source: BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2023 Apr 06; Vol. 23 (1), pp. 60. Date of Electronic Publication: 2023 Apr 06.Publisher: BioMed Central Country of Publication: England NLM ID: 101088682 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6947

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Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.

Authors : Sakai T; Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Gifu-City, Gifu, 501-1196, Japan.; Matsuo Y

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology

Source: Scientific reports [Sci Rep] 2021 Mar 01; Vol. 11 (1), pp. 4852. Date of Electronic Publication: 2021 Mar 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.

Authors : Barbieri F; Sezione di Farmacologia, Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto Xv, 2, 16132, Genoa, Italy.; Bosio AG

Subjects: Biguanides/Biguanides/Biguanides/*therapeutic use ; Chloride Channels/Chloride Channels/Chloride Channels/*metabolism ; Glioblastoma/Glioblastoma/Glioblastoma/*genetics

Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Feb 08; Vol. 41 (1), pp. 53. Date of Electronic Publication: 2022 Feb 08.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

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Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length.

Authors : Xu S; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha 410205, China.; Cao Y

Subjects: Adenylate Kinase/Adenylate Kinase/Adenylate Kinase/*metabolism ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemical synthesis ; Biguanides/Biguanides/Biguanides/*chemical synthesis

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 24; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells.

Authors : Markowicz-Piasecka M; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego1, 90-151 Lodz, Poland.; Sadowski K

Source: International journal of molecular sciences [Int J Mol Sci] 2021 May 26; Vol. 22 (11). Date of Electronic Publication: 2021 May 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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نتائج البحث

فلترة النتائج

Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients.

Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent.

Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.

Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth.

Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System.

Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.

Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length.

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells.

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