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Academic Journal

Adaptive designs were primarily used but inadequately reported in early phase drug trials.

  • Authors : Wang Y; Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Chinese Evidence-based Medicine Center and Chinese Cochrane Center, Sichuan University, Chengdu, 610041, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, 610041, China.

Subjects: Research Design*/Research Design*/Research Design*/standards ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/statistics & numerical data

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jun 05; Vol. 24 (1), pp. 130. Date of Electronic Publication: 2024 Jun 05.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

The "what, why, and how?" of story completion in health services research: a scoping review.

  • Authors : Pong CY; Health Services & Systems Research, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.; Roberts NJ

Subjects: Health Services Research*/Health Services Research*/Health Services Research*/statistics & numerical data ; Qualitative Research* ; Research Design*

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jul 23; Vol. 24 (1), pp. 159. Date of Electronic Publication: 2024 Jul 23.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

Bayesian sequential monitoring strategies for trials of digestive cancer therapeutics.

  • Authors : Mulier G; ECSTRRA team UMR 1153, INSERM, Saint-Louis hospital, 1 avenue Claude Vellefaux, Paris, 75010, France. .; Service de Biostatistique et Information Médicale, AP-HP Saint-Louis hospital, 1 avenue Claude Vellefaux, Paris, 75010, France. .

Subjects: Bayes Theorem* ; Research Design*; Humans

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jul 19; Vol. 24 (1), pp. 154. Date of Electronic Publication: 2024 Jul 19.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

Hypothesis testing and sample size considerations for the test-negative design.

  • Authors : Huo Y; Gilead Sciences, Inc, Foster City, CA, USA.; Yang Y

Subjects: Research Design*; Humans ; Sample Size

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jul 16; Vol. 24 (1), pp. 151. Date of Electronic Publication: 2024 Jul 16.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

Silence is golden, but my measures still see-why cheaper-but-noisier outcome measures in large simple trials can be more cost-effective than gold standards.

  • Authors : Woolf B; Department of Psychological Science, University of Bristol, 12a Priory Road, Bristol, BS8 1TU, UK. .; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. .

Subjects: Cost-Benefit Analysis* ; Research Design*/Research Design*/Research Design*/standards ; Clinical Trials as Topic*/Clinical Trials as Topic*/Clinical Trials as Topic*/economics

  • Source: Trials [Trials] 2024 Aug 12; Vol. 25 (1), pp. 532. Date of Electronic Publication: 2024 Aug 12.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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Academic Journal

Clinical trials with mechanism evaluation of intervention(s): mind the power and sample size calculation.

  • Authors : Lee KM; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK. .; Hellier J

Subjects: Computer Simulation* ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods ; Research Design*

  • Source: Trials [Trials] 2024 Aug 06; Vol. 25 (1), pp. 527. Date of Electronic Publication: 2024 Aug 06.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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Academic Journal

The impact of heterogeneity on the analysis of platform trials with normally distributed outcomes.

  • Authors : Lee KM; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK. .; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. .

Subjects: Research Design*/Research Design*/Research Design*/statistics & numerical data; Humans ; Clinical Trials as Topic/Clinical Trials as Topic/Clinical Trials as Topic/methods

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jul 30; Vol. 24 (1), pp. 163. Date of Electronic Publication: 2024 Jul 30.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

Design and modeling of order of addition experiment with component effects.

  • Authors : Liu J; College of Mathematics, Jiaying University, Meizhou, 514011, Guangdong, China. .; Department of Statistics, College of Mathematics and Computer Science, Hunan Normal University, Changsha, 410081, Hunan, China. .

Subjects: Research Design*; Humans ; Glioblastoma/Glioblastoma/Glioblastoma/drug therapy

  • Source: Scientific reports [Sci Rep] 2024 Jul 23; Vol. 14 (1), pp. 16943. Date of Electronic Publication: 2024 Jul 23.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The performance of a Bayesian value-based sequential clinical trial design in the presence of an equivocal cost-effectiveness signal: evidence from the HERO trial.

  • Authors : Welch C; York Trials Unit, Department of Health Sciences, University of York, Heslington, York, YO10 5DD, UK. .; Forster M

Subjects: Bayes Theorem* ; Cost-Benefit Analysis*/Cost-Benefit Analysis*/Cost-Benefit Analysis*/methods ; Cost-Benefit Analysis*/Cost-Benefit Analysis*/Cost-Benefit Analysis*/statistics & numerical data

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2024 Jul 19; Vol. 24 (1), pp. 155. Date of Electronic Publication: 2024 Jul 19.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

The development of a set of key points to aid clinicians and researchers in designing and conducting n-of-1 trials.

  • Authors : Chatters R; Sheffield Clinical Trials Research Unit (CTRU), Sheffield Centre for Health and Related Research (SCHARR), The University of Sheffield, Sheffield, UK. .; Hawksworth O

Subjects: Research Design* ; Stakeholder Participation* ; Research Personnel*

  • Source: Trials [Trials] 2024 Jul 11; Vol. 25 (1), pp. 473. Date of Electronic Publication: 2024 Jul 11.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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