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Academic Journal

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.

  • Authors : Martinez SE; Comparative Pharmacogenomics Laboratory, Program in Individualized Medicine (PrIMe), Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America. .; Andresen MC

Subjects: Genetic Variation*; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*metabolism

  • Source: Scientific reports [Sci Rep] 2020 Jan 09; Vol. 10 (1), pp. 69. Date of Electronic Publication: 2020 Jan 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.

  • Authors : Nobutani K; Department of Medicine, Knapp Center for Biomedical Center, The University of Chicago, Chicago, Illinois.; Miyoshi J

Subjects: ATP Binding Cassette Transporter, Subfamily B/ATP Binding Cassette Transporter, Subfamily B/ATP Binding Cassette Transporter, Subfamily B/*genetics ; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*genetics ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*genetics

  • Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2017 Oct; Vol. 5 (5).Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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Academic Journal

Identification and characterization of the steroid 15α-hydroxylase gene from Penicillium raistrickii.

  • Authors : Jia L; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.; Dong J

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*genetics ; Penicillium/Penicillium/Penicillium/*enzymology ; Penicillium/Penicillium/Penicillium/*genetics

  • Source: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2017 Aug; Vol. 101 (16), pp. 6409-6418. Date of Electronic Publication: 2017 Jun 29.Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.

  • Authors : Kumar R; Biological Sciences, Clemson University, Clemson, SC, United States of America.; Mota LC

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*genetics ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*genetics ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*genetics

  • Source: PloS one [PLoS One] 2017 Mar 28; Vol. 12 (3), pp. e0174355. Date of Electronic Publication: 2017 Mar 28 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.

  • Authors : Ohno M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.; Kanayama T

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Fatty Liver/Fatty Liver/Fatty Liver/*metabolism ; Liver/Liver/Liver/*metabolism

  • Source: PloS one [PLoS One] 2014 Dec 26; Vol. 9 (12), pp. e115663. Date of Electronic Publication: 2014 Dec 26 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus.

  • Authors : Tatematsu K; Laboratory of Radiochemistry, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu 502-8585, Japan.; Koide A

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*genetics ; Dimethylnitrosamine/Dimethylnitrosamine/Dimethylnitrosamine/*analogs & derivatives ; Esophagus/Esophagus/Esophagus/*drug effects

  • Source: Mutagenesis [Mutagenesis] 2013 Mar; Vol. 28 (2), pp. 161-9. Date of Electronic Publication: 2013 Jan 15.Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation.

  • Authors : Lo WS; National Research Institute of Chinese Medicine, No. 155-1, Li-Nong Street, Sec. 2, Taipei, 112, Taiwan, ROC.; Lim YP

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors ; Cytochrome P-450 CYP2B1/Cytochrome P-450 CYP2B1/Cytochrome P-450 CYP2B1/*biosynthesis ; Furocoumarins/Furocoumarins/Furocoumarins/*pharmacology

  • Source: Archives of toxicology [Arch Toxicol] 2012 Dec; Vol. 86 (12), pp. 1927-38. Date of Electronic Publication: 2012 Jul 12.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.

  • Authors : Damiri B; Environmental Toxicology Program, Clemson University, Clemson, South Carolina 29634, USA.; Holle E

Subjects: Gene Knockdown Techniques* ; Genetic Vectors* ; RNA Interference*

  • Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2012 Feb; Vol. 125 (2), pp. 368-81. Date of Electronic Publication: 2011 Nov 14.Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6.

  • Authors : Chen X; Department of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Pan LQ

Subjects: Polymorphism, Genetic*; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*metabolism

  • Source: PloS one [PLoS One] 2012; Vol. 7 (6), pp. e38495. Date of Electronic Publication: 2012 Jun 12.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.

  • Authors : Khanna A; Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.; Okkeri J

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*metabolism ; MAP Kinase Kinase 2/MAP Kinase Kinase 2/MAP Kinase Kinase 2/*metabolism

  • Source: PloS one [PLoS One] 2011 Mar 22; Vol. 6 (3), pp. e17979. Date of Electronic Publication: 2011 Mar 22.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet

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