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  • 1-10 ل  54,036 نتائج ل ""inhibitors""

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Subject : antineoplastic agents
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Academic Journal

Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors.

  • Authors : Kandeel MM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; AbdElhameid MK

Subjects: Indoles*/Indoles*/Indoles*/pharmacology ; Indoles*/Indoles*/Indoles*/chemistry ; Indoles*/Indoles*/Indoles*/chemical synthesis

  • Source: Molecules (Basel, Switzerland) [Molecules] 2025 Feb 28; Vol. 30 (5). Date of Electronic Publication: 2025 Feb 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors.

  • Authors : Kołodziej-Sobczak D; Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089, Bydgoszcz, Poland. .; Sobczak Ł

Subjects: Molecular Docking Simulation* ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis

  • Source: Scientific reports [Sci Rep] 2025 Feb 10; Vol. 15 (1), pp. 4892. Date of Electronic Publication: 2025 Feb 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia.

  • Authors : Li K; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.; Chinese Medicinal Materials Breeding Innovation Center of Yuelushan Laboratory, Changsha 410128, China.

Subjects: Myeloid Cell Leukemia Sequence 1 Protein*/Myeloid Cell Leukemia Sequence 1 Protein*/Myeloid Cell Leukemia Sequence 1 Protein*/antagonists & inhibitors ; Myeloid Cell Leukemia Sequence 1 Protein*/Myeloid Cell Leukemia Sequence 1 Protein*/Myeloid Cell Leukemia Sequence 1 Protein*/metabolism ; Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/Proto-Oncogene Proteins c-bcl-2*/antagonists & inhibitors

  • Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 18; Vol. 26 (6). Date of Electronic Publication: 2025 Mar 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years.

  • Authors : Mancuso F; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.; Di Chio C

Subjects: Proteasome Inhibitors*/Proteasome Inhibitors*/Proteasome Inhibitors*/chemistry ; Proteasome Inhibitors*/Proteasome Inhibitors*/Proteasome Inhibitors*/pharmacology ; Proteasome Inhibitors*/Proteasome Inhibitors*/Proteasome Inhibitors*/therapeutic use

  • Source: Molecules (Basel, Switzerland) [Molecules] 2025 Feb 06; Vol. 30 (3). Date of Electronic Publication: 2025 Feb 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Targeting MAO-B with Small-Molecule Inhibitors: A Decade of Advances in Anticancer Research (2012-2024).

  • Authors : Alsaad I; Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman 11942, Jordan.; Abdel Rahman DMA

Subjects: Monoamine Oxidase*/Monoamine Oxidase*/Monoamine Oxidase*/metabolism ; Monoamine Oxidase*/Monoamine Oxidase*/Monoamine Oxidase*/chemistry ; Monoamine Oxidase Inhibitors*/Monoamine Oxidase Inhibitors*/Monoamine Oxidase Inhibitors*/chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 31; Vol. 30 (1). Date of Electronic Publication: 2024 Dec 31.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Discovery and Optimization of Ergosterol Peroxide Derivatives as Novel Glutaminase 1 Inhibitors for the Treatment of Triple-Negative Breast Cancer.

  • Authors : Luo R; College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.; Zhao H

Subjects: Glutaminase*/Glutaminase*/Glutaminase*/antagonists & inhibitors ; Glutaminase*/Glutaminase*/Glutaminase*/metabolism ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/drug therapy

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Sep 14; Vol. 29 (18). Date of Electronic Publication: 2024 Sep 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics.

  • Authors : Sulaimani MN; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.; Ahmed S

Subjects: Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/chemistry ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology

  • Source: PloS one [PLoS One] 2025 Jan 24; Vol. 20 (1), pp. e0311954. Date of Electronic Publication: 2025 Jan 24 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents.

  • Authors : Rodriguez-Paniagua A; Departamento de Química Orgánica I, Facultad de Farmacia and Centro de Investigación Lascaray (Lascaray Research Center), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.; Tesauro C

Subjects: Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/pharmacology ; Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/chemical synthesis ; Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/Topoisomerase I Inhibitors*/chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 19; Vol. 29 (24). Date of Electronic Publication: 2024 Dec 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies.

  • Authors : Mohamed AH; Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.; Alshammari MB

Subjects: Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/pharmacology ; Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/chemistry ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2311818. Date of Electronic Publication: 2024 Mar 15.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Recent Advances in Peptide Inhibitors Targeting Wild-Type Ras Protein Interactions in Cancer Therapy.

  • Authors : Qin W; Pharmaceutical College, Guangxi Medical University, Nanning 530021, China.; Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Guangxi Medical University, Nanning 530021, China.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; ras Proteins*/ras Proteins*/ras Proteins*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2025 Feb 08; Vol. 26 (4). Date of Electronic Publication: 2025 Feb 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 ل  54,036 نتائج ل ""inhibitors""