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ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.

• Authors : Tanaka T; Brander Cancer Research Institute, New York Medical College, Valhalla, NY 10532, USA.; Kurose A

Subjects: Topoisomerase I Inhibitors*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

• Source: Cell proliferation [Cell Prolif] 2006 Feb; Vol. 39 (1), pp. 49-60.Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications

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Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis.

• Authors : Ying Liu¹ ; Parry, Joshua A.¹ ; Chin, Anna¹

• Source: Molecular Cancer. 2008, Vol. 7, Special section p1-10. 10p. 1 Black and White Photograph, 3 Diagrams.

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Ocoxin Oral Solution Triggers DNA Damage and Cell Death in Ovarian Cancer.

• Authors : Almaraz-Postigo, Sheila¹ ; Sanz, Eduardo² ; Pandiella, Atanasio¹

Subjects: *IN vitro studies; *BIOLOGICAL models; *PHOSPHORYLATION

• Source: Nutrients. Aug2024, Vol. 16 Issue 15, p2416. 15p.

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Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-x L /Bcl-w Inhibitors.

• Authors : Peng Z; Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.; Clinical Medicine, University of South China, Hengyang 421001, China.

Subjects: Melanoma*/Melanoma*/Melanoma*/metabolism ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Pyrimidines*

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 19; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Pol η is required for DNA replication during nucleotide deprivation by hydroxyurea

• Authors : Charles L. Limoli; S de Feraudy; D. Karentz

Subjects: DNA Replication; Cancer Research; DNA Repair

• Source: Oncogene. 26:5713-5721

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Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor

• Authors : Teresa Marple; Mariana Yaneva; Paul Hasty

Subjects: Ku80; DNA Ligases; DNA Repair

• Source: Nucleic Acids Research

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Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells.

• Authors : Costa MI; Laboratory of Oncobiology and Hematology (LOH) and University Clinic of Hematology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.

Subjects: Antineoplastic Agents* ; Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/Leukemia, Myeloid, Acute*/genetics; DNA Damage

• Source: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 25; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Dose–response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686288).

• Authors : Meng, L.-h.¹; Kohn, K. W.¹; Pommier, Y.¹

• Source: Oncogene. 7/19/2007, Vol. 26 Issue 33, p4806-4816. 11p. 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 3 Graphs.

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A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms.

• Authors : Szikriszt B; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.; Póti Á

Subjects: DNA Damage*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Lymphocytes/Lymphocytes/Lymphocytes/*pathology

• Source: Mutagenesis [Mutagenesis] 2021 Apr 28; Vol. 36 (1), pp. 75-86.Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print Cited Medium: Internet ISSN:

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Chalcone Methoxy Derivatives Exhibit Antiproliferative and Proapoptotic Activity on Canine Lymphoma and Leukemia Cells.

• Authors : Pawlak A; Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31, 50-375 Wrocław, Poland.; Henklewska M

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

• Source: Molecules (Basel, Switzerland) [Molecules] 2020 Sep 23; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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