نتائج البحث

A phase I trial of topotecan plus tivantinib in patients with advanced solid tumors

• Authors : Liu, Stephen V; Groshen, Susan G; Kelly, Karen

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Lung Cancer

• Source: Cancer Chemotherapy and Pharmacology. 82(4)

تفاصيل العنوان

Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib.

• Authors : Nishiya Y; a Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , Tokyo , Japan .; Nakai D

Subjects: Alcohol Dehydrogenase/Alcohol Dehydrogenase/Alcohol Dehydrogenase/*metabolism ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*metabolism ; Cytochrome P-450 CYP2C19/Cytochrome P-450 CYP2C19/Cytochrome P-450 CYP2C19/*metabolism

• Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2016 Nov; Vol. 46 (11), pp. 967-76. Date of Electronic Publication: 2016 Feb 22.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.

• Authors : Xiang Q; Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. .; Department of Hepatopancreatobiliary Surgery, The First People's Hospital of Foshan, Foshan, 528000, China. .

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*drug therapy

• Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2015 Oct 12; Vol. 34, pp. 118. Date of Electronic Publication: 2015 Oct 12.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

تفاصيل العنوان

A Phase-1b study of tivantinib (ARQ 197) in adult patients with hepatocellular carcinoma and cirrhosis.

• Authors : Santoro A; Medical Oncology and Hematology Unit, Humanitas Cancer Center, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano (Milan), Italy.; Simonelli M

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*drug therapy ; Liver Cirrhosis/Liver Cirrhosis/Liver Cirrhosis/*complications

• Source: British journal of cancer [Br J Cancer] 2013 Jan 15; Vol. 108 (1), pp. 21-4. Date of Electronic Publication: 2013 Jan 03.Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited

تفاصيل العنوان

Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib

• Authors : Daisuke Nakai; Tomoko Takayama; Ronald E. Savage

Subjects: Health, Toxicology and Mutagenesis; Metabolite; Glucuronidation

• Source: Xenobiotica; the fate of foreign compounds in biological systems. 46(11)

تفاصيل العنوان

Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma

• Authors : Yingjun Chen; Qingfeng Xiang; Ningning Chen

Subjects: Cancer Research; Vincristine; Carcinoma, Hepatocellular

• Source: Journal of Experimental & Clinical Cancer Research : CR

تفاصيل العنوان

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance.

• Authors : Wu, Zhuo-Xun¹ (AUTHOR) ; Yang, Yuqi¹ (AUTHOR) ; Teng, Qiu-Xu¹ (AUTHOR)

• Source: Cancers. Jan2020, Vol. 12 Issue 1, p186. 1p.

تفاصيل العنوان

A Phase II Study of the c-Met Inhibitor Tivantinib in Combination with FOLFOX for the Treatment of Patients with Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction, or Stomach.

• Authors : Pant, Shubham¹ (AUTHOR); Patel, Manish² (AUTHOR); Kurkjian, Carla¹ (AUTHOR)

• Source: Cancer Investigation. 2017, Vol. 35 Issue 7, p463-472. 10p.

تفاصيل العنوان

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.

• Authors : Alhothali M; Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA. .; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. .

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/Carcinoma, Pancreatic Ductal/*drug therapy ; Deoxycytidine/Deoxycytidine/Deoxycytidine/*analogs & derivatives

• Source: International journal of molecular sciences [Int J Mol Sci] 2019 May 16; Vol. 20 (10). Date of Electronic Publication: 2019 May 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

• Authors : Geeta Iyer; Mevin Mathew; Marwa Alhothali

Subjects: endocrine system diseases; fendiline; Cell Cycle Proteins

• Source: International Journal of Molecular SciencesVolume 20Issue 10International Journal of Molecular Sciences, Vol 20, Iss 10, p 2423 (2019)

تفاصيل العنوان