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  • 1-10 ل  128 نتائج ل ""HSP90 Heat-Shock Proteins""

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Subject : antineoplastic agents
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Academic Journal

Design, synthesis and biological studies of new isoxazole compounds as potent Hsp90 inhibitors.

  • Authors : Keshavarzipour F; Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 81746-7346, Isfahan, Iran.; Abbasi M

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; Isoxazoles*/Isoxazoles*/Isoxazoles*/pharmacology

  • Source: Scientific reports [Sci Rep] 2024 Nov 14; Vol. 14 (1), pp. 28017. Date of Electronic Publication: 2024 Nov 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer.

  • Authors : Jia L; Department of Pharmacy, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, China.; Yang H

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; Hyaluronan Receptors*/Hyaluronan Receptors*/Hyaluronan Receptors*/metabolism

  • Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Apr 22; Vol. 22 (1), pp. 198. Date of Electronic Publication: 2024 Apr 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Academic Journal

Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.

  • Authors : El-Kalyoubi S; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; El-Sebaey SA

Subjects: Pyrimidines*/Pyrimidines*/Pyrimidines*/chemical synthesis ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/chemical synthesis

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2198163.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice.

  • Authors : Youssef ME; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt.; Cavalu S

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 06; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Identification of Novel Natural Dual HDAC and Hsp90 Inhibitors for Metastatic TNBC Using e-Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Studies.

  • Authors : AbdElmoniem N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.; H Abdallah M

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/drug therapy ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

HSP70 Is a Critical Regulator of HSP90 Inhibitor's Effectiveness in Preventing HCl-Induced Chronic Lung Injury and Pulmonary Fibrosis.

  • Authors : Colunga Biancatelli RML; Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23509, USA.; Division of Pulmonary and Critical Care, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA.

Subjects: Pulmonary Fibrosis*/Pulmonary Fibrosis*/Pulmonary Fibrosis*/chemically induced ; Pulmonary Fibrosis*/Pulmonary Fibrosis*/Pulmonary Fibrosis*/drug therapy ; Pulmonary Fibrosis*/Pulmonary Fibrosis*/Pulmonary Fibrosis*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.

  • Authors : Peng S; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.; Woodruff J

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/chemistry; Adenosine Triphosphate/Adenosine Triphosphate/Adenosine Triphosphate/metabolism

  • Source: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2022 May 01; Vol. 78 (Pt 5), pp. 571-585. Date of Electronic Publication: 2022 Apr 08.Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1 H )-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90.

  • Authors : Larghi EL; CNRS, BioCIS, Université Paris-Saclay, 92290 Châtenay-Malabry, France.; Instituto de Química Rosario (IQUIR) CONICET/UNR, FBioyF, Rosario S2002LRK, Argentina.

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; Protein Folding*

  • Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jan 09; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Targeted Inhibition of Hsp90 in Combination with Metformin Modulates Programmed Cell Death Pathways in A549 Lung Cancer Cells.

  • Authors : Hasan A; Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Integral University, Kursi Road, Lucknow, 226026, India.; Department of Bioengineering, Faculty of Engineering, Integral University, Kursi Road, Lucknow, 226026, India.

Subjects: Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/metabolism ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects

  • Source: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2023 Dec; Vol. 195 (12), pp. 7338-7378. Date of Electronic Publication: 2023 Mar 31.Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A Coumarin-Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins.

  • Authors : Nirgude S; Institute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bangalore 560100, Karnataka, India.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Subjects: Coumarins*/Coumarins*/Coumarins*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Jul 05; Vol. 28 (13). Date of Electronic Publication: 2023 Jul 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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  • 1-10 ل  128 نتائج ل ""HSP90 Heat-Shock Proteins""