Source: PloS one [PLoS One] 2022 Apr 12; Vol. 17 (4), pp. e0266476. Date of Electronic Publication: 2022 Apr 12 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.

Authors : Ando K; Department of Clinical Diagnostic Oncology, Showa University Clinical Research Institute for Clinical Pharmacology and Therapeutics, 6-11-11 kita-karasuyama, setagaya-ku, Tokyo 157-8577, Japan. .; Department of Biomedical Sciences, Division of Biochemistry, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan. .

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Apoptosis/Apoptosis/Apoptosis/*genetics

Source: International journal of molecular sciences [Int J Mol Sci] 2019 Jul 29; Vol. 20 (15). Date of Electronic Publication: 2019 Jul 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations.

Authors : Gao X; School of Chemistry and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China. .; Han L

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Carbazoles/Carbazoles/Carbazoles/*chemistry ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*antagonists & inhibitors

Source: Molecules (Basel, Switzerland) [Molecules] 2016 May 05; Vol. 21 (5). Date of Electronic Publication: 2016 May 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer.

Authors : Hur J; Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.; Department of Biomedical Science, The Graduate School, CHA University, Seongnam 13496, Korea.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

Source: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 27; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin.

Authors : Liu B; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, 730000, China.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Biphenyl Compounds/Biphenyl Compounds/Biphenyl Compounds/*pharmacology ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*antagonists & inhibitors

Source: Radiation and environmental biophysics [Radiat Environ Biophys] 2020 Nov; Vol. 59 (4), pp. 723-732. Date of Electronic Publication: 2020 Aug 28.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0415677 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Discovery and in silico evaluation of aminoarylbenzosuberene molecules as novel checkpoint kinase 1 inhibitor determinants

Authors : Jatin Sharma; Vijay Kumar Bhardwaj; Rahul Singh

Subjects: Molecular Docking Simulation; 0301 basic medicine; 03 medical and health sciences

Source: Genomics. 113:707-715

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Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer.

Authors : Gralewska P; Department of Medical Biophysics, Faculty of Biology and Environmental Protection, Institute of Biophysics, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.; Gajek A

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use ; Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/*metabolism ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*metabolism

Source: Journal of hematology & oncology [J Hematol Oncol] 2020 Apr 21; Vol. 13 (1), pp. 39. Date of Electronic Publication: 2020 Apr 21.Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722

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The Antiproliferative Activity of Oxypeucedanin via Induction of G 2 /M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells.

Authors : Park SH; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.; Hong JY

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*drug therapy ; Furocoumarins/Furocoumarins/Furocoumarins/*pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2020 Jan 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.

Authors : Cui Q; School of Public Health, Guangzhou Medical University, Guangzhou 511436, China.; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*antagonists & inhibitors ; Drug Resistance, Multiple/Drug Resistance, Multiple/Drug Resistance, Multiple/*genetics

Source: International journal of molecular sciences [Int J Mol Sci] 2019 Aug 22; Vol. 20 (17). Date of Electronic Publication: 2019 Aug 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models

Authors : Caitlin D. Lowery; Michele Dowless; Matthew Renschler

Subjects: Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Antineoplastic Agents

Source: Clinical Cancer Research. 25:2278-2289

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نتائج البحث

فلترة النتائج

Ataxia telangiectasia and Rad3-related inhibition by AZD6738 enhances gemcitabine-induced cytotoxic effects in bladder cancer cells.

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.

In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations.

Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer.

Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin.

Discovery and in silico evaluation of aminoarylbenzosuberene molecules as novel checkpoint kinase 1 inhibitor determinants

Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer.

The Antiproliferative Activity of Oxypeucedanin via Induction of G 2 /M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells.

Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models

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