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Academic Journal

Human microglial cells as a therapeutic target in a neurodevelopmental disease model

Authors : Mesci, Pinar; LaRock, Christopher N; Jeziorski, Jacob J

Subjects: Biochemistry and Cell Biology; Biological Sciences; Neurosciences

Source: Stem Cell Reports. 19(8)

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Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor

Authors : Correia, Cláudia; Christoffersson, Jonas; Tejedor, Sandra

Subjects: acetyl-CoA carboxylase 2 (ACC2); cardiac hypertrophy; human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) maturation

Source: Cells. 13(16)

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Academic Journal

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Authors : Arang, Nadia; Lubrano, Simone; Ceribelli, Michele

Subjects: Biomedical and Clinical Sciences; Rare Diseases; Cancer

Source: Cell Reports Medicine. 4(11)

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Academic Journal

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening

Authors : Griffin, Katherine H; Thorpe, Steven W; Sebastian, Aimy

Subjects: Biomedical and Clinical Sciences; Engineering; Oncology and Carcinogenesis

Source: Proceedings of the National Academy of Sciences of the United States of America. 120(39)

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Academic Journal

Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models.

Authors : Rupert, Christofer; Dell' Aversana, Carmela; Mosca, Laura

Subjects: Cell Line; Tumor; Mitochondria

Source: Journal of experimental & clinical cancer research : CR. 42(1)

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Academic Journal

An animal-free preclinical drug screening platform based on human precision-cut kidney slices

Authors : Mutsaers, Henricus A M; Jensen, Michael Schou; Kresse, Jean-Claude

Subjects: Animals; Humans; Drug Evaluation

Source: Mutsaers , H A M , Jensen , M S , Kresse , J-C , Tingskov , S J , Madsen , M G & Nørregaard , R 2023 , ' An animal-free preclinical drug

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Academic Journal

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Authors : Lee, EunJung; Archasappawat, Suyakarn; Ji, Keely

Subjects: Biological Sciences; Biomedical and Clinical Sciences; Oncology and Carcinogenesis

Source: Cell Death & Disease, vol 14, iss 9

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A Hydrazine–Hydrazone Adamantine Compound Shows Antimycobacterial Activity and Is a Probable Inhibitor of MmpL3

Authors : Julien Briffotaux; Yanji Xu; Wei Huang

Subjects: Mammals; tuberculosis; MmpL3

Source: Molecules; Volume 27; Issue 20; Pages: 7130

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Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus

Authors : Yangzhen Chen; Yecheng You; Shuqi Wang

Subjects: SARS-CoV-2; Swine; Organic Chemistry

Source: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11250

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New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation

Authors : Beatrice-Cristina Ivan; Stefania-Felicia Barbuceanu; Camelia Mia Hotnog

Subjects: Molecular Structure; Organic Chemistry; Endothelial Cells

Source: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8854

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فلترة النتائج

Human microglial cells as a therapeutic target in a neurodevelopmental disease model

Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening

Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models.

An animal-free preclinical drug screening platform based on human precision-cut kidney slices

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

A Hydrazine–Hydrazone Adamantine Compound Shows Antimycobacterial Activity and Is a Probable Inhibitor of MmpL3

Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus

New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation

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