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Academic Journal

The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase β on Enzyme Activities.

  • Authors : Kladova OA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.; Tyugashev TE

Subjects: DNA Polymerase beta*/DNA Polymerase beta*/DNA Polymerase beta*/chemistry ; DNA Polymerase beta*/DNA Polymerase beta*/DNA Polymerase beta*/genetics ; DNA Polymerase beta*/DNA Polymerase beta*/DNA Polymerase beta*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 10; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.

  • Authors : Egbe E; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.; Levy CW

Subjects: Amino Acid Substitution* ; Computer Simulation* ; Protein Folding*

  • Source: PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235133. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.

  • Authors : Unciuleac MC; Molecular Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.; Goldgur Y

Subjects: Alanine* ; Amino Acid Substitution*; Lysine/Lysine/Lysine/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5603-5615.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate.

  • Authors : Kim H; Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.; Kim S

Subjects: Amino Acid Substitution*; Escherichia coli/Escherichia coli/Escherichia coli/*growth & development ; Mixed Function Oxygenases/Mixed Function Oxygenases/Mixed Function Oxygenases/*genetics

  • Source: BMC microbiology [BMC Microbiol] 2020 May 06; Vol. 20 (1), pp. 109. Date of Electronic Publication: 2020 May 06.Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180

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Academic Journal

Proteome-wide analysis of nonsynonymous single-nucleotide variations in active sites of human proteins.

  • Authors : Dingerdissen H; Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA.; Motwani M

Subjects: Amino Acid Substitution* ; Catalytic Domain* ; Genome, Human* Lacrimoauriculodentodigital syndrome

  • Source: The FEBS journal [FEBS J] 2013 Mar; Vol. 280 (6), pp. 1542-62. Date of Electronic Publication: 2013 Feb 24.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

Structure-guided systems-level engineering of oxidation-prone methionine residues in catalytic domain of an alkaline α-amylase from Alkalimonas amylolytica for significant improvement of both oxidative stability and catalytic efficiency.

  • Authors : Yang H; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.; Liu L

Subjects: Amino Acid Substitution* ; Methionine* ; Mutation, Missense*

  • Source: PloS one [PLoS One] 2013; Vol. 8 (3), pp. e57403. Date of Electronic Publication: 2013 Mar 15.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Improvement of alkaliphily of Bacillus alkaline xylanase by introducing amino acid substitutions both on catalytic cleft and protein surface.

  • Authors : Umemoto H; Department of Bioengineering, Tokyo Institute of Technology, 4529 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.; Ihsanawati

Subjects: Amino Acid Substitution* ; Catalytic Domain*; Bacillus/Bacillus/Bacillus/*enzymology

  • Source: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2009 Apr 23; Vol. 73 (4), pp. 965-7. Date of Electronic Publication: 2009 Apr 07.Publisher: Oxford University Press Country of Publication: England NLM ID: 9205717 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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