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  • 1-10 ل  272 نتائج ل ""Thiazoles""

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Subject : alzheimer disease
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Academic Journal

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors.

  • Authors : Góral I; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland.; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 16 Lazarza St., 31-530 Krakow, Poland.

Subjects: tau Proteins*/tau Proteins*/tau Proteins*/metabolism ; Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/Glycogen Synthase Kinase 3 beta*/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 02; Vol. 29 (11). Date of Electronic Publication: 2024 Jun 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study.

  • Authors : Engels-Domínguez N; The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.

Subjects: Locus Coeruleus*/Locus Coeruleus*/Locus Coeruleus*/diagnostic imaging ; Locus Coeruleus*/Locus Coeruleus*/Locus Coeruleus*/pathology ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/diagnostic imaging

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jun 17; Vol. 16 (1), pp. 129. Date of Electronic Publication: 2024 Jun 17.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

[1- 11 C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects.

  • Authors : Mehta NH; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Harvard Medical School, Boston, MA, USA.

Subjects: Neurodegenerative Diseases*/Neurodegenerative Diseases*/Neurodegenerative Diseases*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism; Animals

  • Source: Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Apr 02; Vol. 21 (1), pp. 30. Date of Electronic Publication: 2024 Apr 02.Publisher: Biomed Central Country of Publication: England NLM ID: 101553157 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-8118

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Academic Journal

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors.

  • Authors : Khan S; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.; Ullah H

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy; Humans ; Molecular Docking Simulation

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 05; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Masitinib for mild-to-moderate Alzheimer's disease: results from a randomized, placebo-controlled, phase 3, clinical trial.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy; Humans ; Activities of Daily Living

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Feb 28; Vol. 15 (1), pp. 39. Date of Electronic Publication: 2023 Feb 28.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives.

  • Authors : Hussain R; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.; Ullah H

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/chemistry; Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 18; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Subjective sleep parameters in prodromal Alzheimer's disease: a case-control study.

  • Authors : Borges CR; Departamento de Neurologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil.; Piovezan RD

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/diagnostic imaging ; Cognitive Dysfunction*/Cognitive Dysfunction*/Cognitive Dysfunction*/diagnostic imaging; Aged

  • Source: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2021 Sep-Oct; Vol. 43 (5), pp. 510-513.Publisher: Associação Brasileira de Psiquiatria Country of Publication: Brazil NLM ID: 100895975 Publication Model: Print Cited Medium: Internet

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Academic Journal

Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.

  • Authors : Terada T; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, 6875 Boulevard LaSalle, Montreal, H4H 1R3, Canada.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Electron Transport Complex I/Electron Transport Complex I/Electron Transport Complex I/*analysis ; tau Proteins/tau Proteins/tau Proteins/*analysis

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2021 Apr 26; Vol. 16 (1), pp. 28. Date of Electronic Publication: 2021 Apr 26.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Design, Synthesis, and Structure-Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer's Disease.

  • Authors : Sağlık BN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*chemical synthesis ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*pharmacology

  • Source: Molecules (Basel, Switzerland) [Molecules] 2020 Sep 20; Vol. 25 (18). Date of Electronic Publication: 2020 Sep 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

  • Authors : Hédou D; Normandie Univ; Uni Rouen

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*chemical synthesis ; Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/*antagonists & inhibitors

  • Source: Molecules (Basel, Switzerland) [Molecules] 2016 Apr 30; Vol. 21 (5). Date of Electronic Publication: 2016 Apr 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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  • 1-10 ل  272 نتائج ل ""Thiazoles""